UBI4P_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UBI4P_SCHPO
• UniProt AC: P0CG72
• Protein Name: Polyubiquitin
• Gene Name: ubi4
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 382
• Subcellular Localization: Cytoplasm. Nucleus.
• Protein Description: Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, and DNA-damage responses. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity)..
• Protein Sequence: MQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGLF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Ubiquitination	--MQIFVKTLTGKTI --CEEEEEECCCCEE	27.37	-
11	Ubiquitination	FVKTLTGKTITLEVE EEEECCCCEEEEEEE	31.36	-
27	Ubiquitination	SDTIDNVKSKIQDKE CCCHHHHHHHCCCCC	52.89	-
33	Ubiquitination	VKSKIQDKEGIPPDQ HHHHCCCCCCCCHHH	41.27	-
55	Phosphorylation	KQLEDGRTLSDYNIQ EECCCCCCCCCCCCC	35.82	24763107
57	Phosphorylation	LEDGRTLSDYNIQKE CCCCCCCCCCCCCCH	37.12	28889911
131	Phosphorylation	KQLEDGRTLSDYNIQ EECCCCCCCCCCCCC	35.82	24763107
133	Phosphorylation	LEDGRTLSDYNIQKE CCCCCCCCCCCCCCH	37.12	28889911
207	Phosphorylation	KQLEDGRTLSDYNIQ EECCCCCCCCCCCCC	35.82	24763107
209	Phosphorylation	LEDGRTLSDYNIQKE CCCCCCCCCCCCCCH	37.12	28889911
283	Phosphorylation	KQLEDGRTLSDYNIQ EECCCCCCCCCCCCC	35.82	24763107
285	Phosphorylation	LEDGRTLSDYNIQKE CCCCCCCCCCCCCCH	37.12	28889911
359	Phosphorylation	KQLEDGRTLSDYNIQ EECCCCCCCCCCCCC	35.82	24763107
361	Phosphorylation	LEDGRTLSDYNIQKE CCCCCCCCCCCCCCH	37.12	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UBI4P_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UBI4P_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UBI4P_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IMP2_SCHPO	imp2	physical	19139265
AAT1_SCHPO	aat1	physical	22194353
ZIP1_SCHPO	zip1	physical	15660136
MEI2_SCHPO	mei2	physical	11702950
AP1_SCHPO	pap1	physical	23209828
MIK1_SCHPO	mik1	physical	10637286
SLP1_SCHPO	slp1	physical	23442800
PCNA_SCHPO	pcn1	physical	16641370
AAT1_SCHPO	aat1	physical	24454826
MEI2_SCHPO	mei2	physical	24741065
CENPA_SCHPO	cnp1	physical	25298518

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.