AP1_SCHPO - dbPTM
AP1_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID AP1_SCHPO
UniProt AC Q01663
Protein Name AP-1-like transcription factor
Gene Name pap1
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 552
Subcellular Localization Nucleus . Cytoplasm . Oxidized pap1 is found predominantly in the nucleus, while reduced pap1 is continuously exported to the cytoplasm by crm1/exportin 1.
Protein Description Transcription activator involved in multidrug resistance, oxidative stress response, and redox homeostasis. Regulates the transcription of genes encoding antioxidant enzymes like catalase ctt1 and components of the cellular thiol-reducing pathways, including the thioredoxin system (trx2, trr1), ABC tansporters involved in multidrug resistance like bfr1/hba2 and pmd1 as well as the gene obr1/apt1. Preferentially binds to promoters with the core binding site 5'-TTA[CG]TAA-3'. Activity of the transcription factor is controlled through oxidation of specific cysteine residues resulting in the alteration of its subcellular location. Oxidative stress induces nuclear accumulation and as a result pap1 transcriptional activity. Required for sty1/spc1-confered staurosporine resistance..
Protein Sequence MSGQTETLSSTSNIPIAKAEPEQSADFSASHKKRGPVSDRSSRRTSSEEVDLMPNVDDEVDGDVKPKKIGRKNSDQEPSSKRKAQNRAAQRAFRKRKEDHLKALETQVVTLKELHSSTTLENDQLRQKVRQLEEELRILKDGSFTFEMSLPHRNPSLSSLPTTGFSSNFAHMKDGISPQSNLHLSPNSIEKPNMHQNVLHNDRSADNLNHRYQVPPTLVDSNSAQGTLSPETPSSSDSPSNLYLNYPKRKSITHLHHDCSALSNGENGEDVADGKQFCQKLSTACGSIACSMLTKTTPHRASVDILSNLHESTVSPPMADESVQRSSEVSKSIPNVELSLNVNQQFVSPFGGTDSFPLPTDTGLDSLFEPDSAIENSHLKNVVMEPELFQAWREPAESLDKEFFNDEGEIDDVFHNYFHNSNENGDLITNSLHGLDFLENANESFPEQMYPFIKHNKDYISNHPDEVPPDGLPQKGKHDTSSQMPSENEIVPAKERAYLSCPKVWSKIINHPRFESFDIDDLCSKLKNKAKCSSSGVLLDERDVEAALNQFN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
38PhosphorylationHKKRGPVSDRSSRRT
HCCCCCCCCCCCCCC		30.3624763107
41PhosphorylationRGPVSDRSSRRTSSE
CCCCCCCCCCCCCHH		32.9424763107
42PhosphorylationGPVSDRSSRRTSSEE
CCCCCCCCCCCCHHH		27.0321712547
45PhosphorylationSDRSSRRTSSEEVDL
CCCCCCCCCHHHCCC		35.1829996109
46PhosphorylationDRSSRRTSSEEVDLM
CCCCCCCCHHHCCCC		33.6629996109
47PhosphorylationRSSRRTSSEEVDLMP
CCCCCCCHHHCCCCC		36.8429996109
74PhosphorylationKKIGRKNSDQEPSSK
HHCCCCCCCCCCCHH		43.6424763107
80PhosphorylationNSDQEPSSKRKAQNR
CCCCCCCHHHHHHHH		47.3921712547
145PhosphorylationILKDGSFTFEMSLPH
HHHCCCEEEEEECCC		22.0021712547
149PhosphorylationGSFTFEMSLPHRNPS
CCEEEEEECCCCCCC		31.3921712547
156PhosphorylationSLPHRNPSLSSLPTT
ECCCCCCCHHHCCCC		44.4225720772
158PhosphorylationPHRNPSLSSLPTTGF
CCCCCCHHHCCCCCC		33.8821712547
159PhosphorylationHRNPSLSSLPTTGFS
CCCCCHHHCCCCCCC		43.6025720772
177PhosphorylationAHMKDGISPQSNLHL
CCCCCCCCCCCCCCC		23.5521712547
180PhosphorylationKDGISPQSNLHLSPN
CCCCCCCCCCCCCCC		44.7524763107
185PhosphorylationPQSNLHLSPNSIEKP
CCCCCCCCCCCCCCC		15.9921712547
188PhosphorylationNLHLSPNSIEKPNMH
CCCCCCCCCCCCCCC		35.1921712547
251PhosphorylationLNYPKRKSITHLHHD
CCCCCCCCCCEEECC		36.4321712547
253PhosphorylationYPKRKSITHLHHDCS
CCCCCCCCEEECCHH		26.0225720772
260PhosphorylationTHLHHDCSALSNGEN
CEEECCHHHHCCCCC		38.0029996109
263PhosphorylationHHDCSALSNGENGED
ECCHHHHCCCCCCCC		42.3729996109
296PhosphorylationACSMLTKTTPHRASV
HHHHHCCCCCCCCHH		40.0821712547
302PhosphorylationKTTPHRASVDILSNL
CCCCCCCHHHHHHHC		21.9329996109
307PhosphorylationRASVDILSNLHESTV
CCHHHHHHHCCCCCC		37.3729996109
312PhosphorylationILSNLHESTVSPPMA
HHHHCCCCCCCCCCC		24.3021712547
313PhosphorylationLSNLHESTVSPPMAD
HHHCCCCCCCCCCCC		23.2425720772
315PhosphorylationNLHESTVSPPMADES
HCCCCCCCCCCCCHH		24.3128889911
398PhosphorylationAWREPAESLDKEFFN
HHHCCHHHCCHHHHC		43.9324763107
480PhosphorylationPQKGKHDTSSQMPSE
CCCCCCCCCCCCCCC		29.9621712547
481PhosphorylationQKGKHDTSSQMPSEN
CCCCCCCCCCCCCCC		25.3221712547
482PhosphorylationKGKHDTSSQMPSENE
CCCCCCCCCCCCCCC		32.3721712547
486PhosphorylationDTSSQMPSENEIVPA
CCCCCCCCCCCCCCH		47.9521712547
516PhosphorylationINHPRFESFDIDDLC
HCCCCCCCCCHHHHH		26.0525720772
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of AP1_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of AP1_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of AP1_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
HOG1_SCHPOsty1physical
9585505
IMA1_SCHPOcut15physical
15937127
IMA2_SCHPOimp1physical
15937127
PRR1_SCHPOprr1physical
22344694
ATF1_SCHPOatf1genetic
16087744
YKW3_SCHPObop1genetic
22681890
MU115_SCHPOmug115genetic
22681890
YFQ6_SCHPOSPAC8E11.06genetic
22681890
MAK3_SCHPOmak3genetic
22681890
APT_SCHPOapt1genetic
22681890
MGR2_SCHPOmgr2genetic
22681890
PPK8_SCHPOppk8genetic
22681890
UAF30_SCHPOspp27genetic
22681890
MBO1_SCHPOmto1genetic
22681890
PPR2_SCHPOppr2genetic
22681890
TRX2_SCHPOtrx2genetic
22681890
NTA1_SCHPOnta1genetic
22681890
FSV1_SCHPOfsv1genetic
22681890
VPS38_SCHPOvps38genetic
22681890
YDHE_SCHPOSPAC6G9.14genetic
22681890
TR112_SCHPOtrm112genetic
22681890
ATP14_SCHPOatp14genetic
22681890
CYSK_SCHPOcys11genetic
22681890
CAND1_SCHPOknd1genetic
22681890
EME1_SCHPOeme1genetic
22681890
ALM1_SCHPOalm1genetic
22681890
YDFE_SCHPOSPAC17C9.14genetic
22681890
FAT2_SCHPOSPCC1827.03cgenetic
22681890
PRZ1_SCHPOprz1genetic
22681890
CSK1_SCHPOcsk1genetic
22681890
UBP16_SCHPOubp16genetic
22681890
MUG73_SCHPOmug73genetic
22681890
MFS1_SCHPOmfs1genetic
22840777
BFR1_SCHPObfr1genetic
22840777
PMD1_SCHPOpmd1genetic
22840777
CAF5_SCHPOcaf5genetic
22840777
ATF1_SCHPOatf1genetic
9585505
AP1_SCHPOpap1physical
24316080
TPX1_SCHPOtpx1genetic
24521463
CATA_SCHPOctt1genetic
24521463
ATF1_SCHPOatf1genetic
24521463
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of AP1_SCHPO

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Related Literatures of Post-Translational Modification

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