PRR1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PRR1_SCHPO
• UniProt AC: O14283
• Protein Name: Transcription factor prr1
• Gene Name: prr1
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 539
• Subcellular Localization: Nucleus .
• Protein Description: Involved in oxidative stress. Transcription factor that acts upon trr1 and ctt1..
• Protein Sequence: MPSSNGSSDFVRKLFNMLEEPEYRHILRWSDSGDSFIVLDTNEFTKTILPRHFKHSNFASFVRQLNKYDFHKVRHEEGAPSIYGEGAWEFRHDDFQLHHKDLLDNIKRKAPSKRNLANENTAPVIENLKQQVDSILDFQKLLDRNLSGLATSYQTILLKMFELKRGIESRDLLMSSIISYLCDLEGSTQRQANPGAMFVPSHPLQELLNAYQALAKGQVATTSPQQIPNQIQQASAATTASSKMTVDTNLGTAQPSLYNTPSSDYELANQEKPADSMASAASLNTPLSSNDHSLNPHAHGSYPMYEKFQPIQHPNPGSFTTHLDSNASMAKSFSQISNDSLAKASSVATSMSQMGAAVPTTGLWKRQPRILLVEDDELSRRMTIKFLTSFDCQVDVAVDGIGAVNKANAGGFDLILMDFILPNLDGLSVTCLIRQYDHNTPILAITSNISMNDAVTYFNHGVTDLLVKPFTKLTLLQLLKKQLLNLLQADNSINMSDVPSTKEAKDDKAPVTFYLENDAPMYPQQMLQDPIQADLQHPH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
60	Phosphorylation	FKHSNFASFVRQLNK HCCCCHHHHHHHHHC	21.82	25720772
134	Phosphorylation	NLKQQVDSILDFQKL HHHHHHHHHHHHHHH	26.62	25720772
221	Phosphorylation	LAKGQVATTSPQQIP HHCCCCCCCCHHHCC	29.02	28889911
223	Phosphorylation	KGQVATTSPQQIPNQ CCCCCCCCHHHCCHH	19.16	28889911
262	Phosphorylation	PSLYNTPSSDYELAN CHHHCCCCHHHHHCC	33.53	27738172
318	Phosphorylation	IQHPNPGSFTTHLDS CCCCCCCCCEECCCC	22.22	24763107
320	Phosphorylation	HPNPGSFTTHLDSNA CCCCCCCEECCCCCH	18.27	21712547
321	Phosphorylation	PNPGSFTTHLDSNAS CCCCCCEECCCCCHH	20.59	21712547
325	Phosphorylation	SFTTHLDSNASMAKS CCEECCCCCHHHHHH	40.43	21712547
328	Phosphorylation	THLDSNASMAKSFSQ ECCCCCHHHHHHHHH	24.43	24763107
332	Phosphorylation	SNASMAKSFSQISND CCHHHHHHHHHHCHH	22.16	21712547
334	Phosphorylation	ASMAKSFSQISNDSL HHHHHHHHHHCHHHH	33.42	28889911
337	Phosphorylation	AKSFSQISNDSLAKA HHHHHHHCHHHHHHH	27.26	24763107
340	Phosphorylation	FSQISNDSLAKASSV HHHHCHHHHHHHHHH	34.18	24763107
346	Phosphorylation	DSLAKASSVATSMSQ HHHHHHHHHHHHHHH	22.19	27738172
418	Phosphorylation	GFDLILMDFILPNLD CCCEEEEECHHCCCC	24.80	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PRR1_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PRR1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PRR1_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MAK2_SCHPO	mak2	genetic	11179424
MAK3_SCHPO	mak3	genetic	11179424
ATF1_SCHPO	atf1	genetic	11179424
AP1_SCHPO	pap1	physical	22344694
YJL4_SCHPO	SPCC14G10.04	physical	26771498

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-221 AND SER-223, ANDMASS SPECTROMETRY.
PubMed: 18257517