MAK3_SCHPO - dbPTM
MAK3_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MAK3_SCHPO
UniProt AC O74539
Protein Name Peroxide stress-activated histidine kinase mak3
Gene Name mak3
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 2344
Subcellular Localization Cytoplasm .
Protein Description Involved in the control of the SAPK-dependent transcriptional response to peroxide stress. Regulates sty1 activity..
Protein Sequence MYSQHELRNKVSLALSSLLRYTFELTPFFELYEADFAYALYAGFELATNRKVVGKFSFQNVHLENEYNILTEIAKDERASKFSPTPIEFTSFPHIDLSACIAYDFGHGAELSTSYAYFRENPAEFVRFCIAICKCIEYLHSKGMVHGEIRLDSFIPISSYDNVYMLTVGSGASYFHNCLQAHNWRKYSEDSESMSRILFISPEQTGRTSYSVGYRTDIYSLGVLFFHYLSDCSPYTGSFVQRIRSILTEPLPDISKSCPKLPHLIFKIIEKMTRKNPDERYTSCSGIVNDLEACLDDIDKGLILNDHVLEKTGRTSLFYLPCSIYGREHEIKLIRKILRNSPRAINHQDKKDLETFNPYYLNAIESESSSQSLSLSQRASEVMPLVILITGCEGIGESSLIQTICDRREGYMAITKFEVSQSIVYSAIVSAVAEFIRQILAEDQLLLNNFFEELKNKLESDLYLLDSVFDLVPEIRSLLQQFSTSSGNTRKTSLLGSNHSSYSDKLGSPTILSTSFSLARPYPEPALVSPSTERPPRSSFSAALMTLLNIIASFKKVTMVIENIHLADESSLIILQKIVYSDLPLTLMITCDKENDHVINRFRLANDRIHEIELKPLSFNAVNSYVQATLHRTDDGLARFSSYVYHISKGVPLLVRNVLLSIYENKIIYFDWKKNRWEVNYDEMYTLDNDYSEPDAFMTAKKKISKLNDSSRAILGWASLLGPSFSFATVKKLCKDTDNIELNVEALQSALREGIIYATSSDDTYTFSRSIYVKAMRDLLNEAKIQIMHACLIDVCLKNRDRYNIFDIAFHINAAFDFVKGDKRSVEYCHYLHLAAEEALKIGANQEALDLYNRCIKMIPHEIPEESDDSYIRCQLIGMYVGCAEAYWVNDNFDTASEMLKLAEEKACNNSEVFPARFLYSRILFEGVHIEECTQYVLSCLKPLGYELKRHSLEDSKSIISALIPRIIDKITKSSEESQSSTDDDDRRIFEILSFLYVGSVATSYFSETAEMAIDFGIAQVEFFLSTVVNSFSAFALVYFAILANSLLEPSEDILFIGNYGEKLNREAENPIIFSRTEYLYVQSLGFIDSTTKERRLTIDYLDRNCVTCSDKHVIISLLLVSSWEKFLTSNNYSNYLADFETTHAQIMEMKPWVGDTSLITQLKRFLMCLQDNIKLDLIKSKSFLSDHNIQLSSPAAQESAKLAFSLHGWINSWYLLALVMHGEWDMAISYGENFKREFKNALLTSSRVFGIFMFTWSLVNKMLICPEFTKQKKYYEQYKENLGFFDSLCIGDNECITRVYFLLLKACGLIMNGLNFEASVMLEEVISLTEKLELFLLQAFAFETVGSIFVSMELYTSATQYLEEAIRNYAALGVKQKARHLRDKFGDLLVSNNLQVSIDEATQTDFPLVFSPERSSIDINASSMRSEKASFEIPFPEEQIDDDVSPVAQDSSLEELLISLDIIDLTSVMRSCQTIASEIELTGLLSTMTQRMLEDSSANAAVIAIRDDVGFKIAAYRTGELNEVFAPPMPITEDQTYVPSRVINYVVHTQKALFSNNINHEFDLQQERWNIENHMGRSVIAIPLYQKKEVFAILYLQGPPSAFHSRHMSVLSILGAQASFAIVNISLFHKVKEATNVNTIIIKAQREALNLVQKSEAKYRSFVDTMPCLLSKLEFDEELRIELFGSFWKEYCGELNINDPNTWKEYVHLDDHLKLQDFLLSHLHNPLPFELEIRIKRKDGVYRWNLTRCTPTTNEKNRTSFLCATIDIDDQKKARATALELARLRSNFLANISHELRTPFSGFYGMLSLLDDTNLDSEQRDIVSAARISCEMLLRVINDLLNFSKLEAGKVTLESDLEFSLESVVCDCMQSVYSACAEKGINLSYNVSPDIPFFTAGDGMKIGQMLKSILDNSVKTVNNGFIRVRAFLAGSSKKNDRDQLQIAFIVEDTREESNAIFLANMINSLNRGCNDYLPMDLSGTALGMSTCLQLCKIMGGSVSVEVSQNNPTFKICYDLKIHELGKERYDIIATPLFQNLTEFNDLIKSKVAIRVSKTSTEYDNITTYLQAARKVLHVFKGLQDLASIFDLSPDSALLRCSVVVVDVYSMDDVKAVEKILKSYPDVHVIYLCCDPSRLNIEQELQKPSGRSFACKKRWGFLQMPCTRENFLKVTLQVFKSNEDTCNFYSYVNEYGESPKPDDDMDRLNKCVGSKILIAEDNPIVRMTLKKQLEHLGMDVDAAEDGKETLQIFESHPDNYYQVCFVDYHMPVYDGLEVTRRMRKIERKHGCAPLPIFALTADMQPTMETQFQEVGITHYLSKPFKKETLIKMLLQYLVNGTDGNANTS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
12PhosphorylationHELRNKVSLALSSLL
HHHHHHHHHHHHHHH		14.9928889911
16PhosphorylationNKVSLALSSLLRYTF
HHHHHHHHHHHHHHH		17.2128889911
17PhosphorylationKVSLALSSLLRYTFE
HHHHHHHHHHHHHHH		32.0728889911
493PhosphorylationSGNTRKTSLLGSNHS
CCCCCCEEECCCCCC		25.3225720772
1795PhosphorylationNFLANISHELRTPFS
HHHHHCCHHHCCCCC		34.02-
2263PhosphorylationYYQVCFVDYHMPVYD
EEEEEEEECCCCCCC		13.84-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MAK3_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MAK3_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MAK3_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
COX19_SCHPOSPCC1672.04cgenetic
22681890
DDB1_SCHPOddb1genetic
22681890
ASL1_SCHPOasl1genetic
22681890
YG58_SCHPOSPBC56F2.08cgenetic
22681890
HAT1_SCHPOhat1genetic
22681890
PPK14_SCHPOppk14genetic
22681890
6PGL_SCHPOSPCC16C4.10genetic
22681890
ATP10_SCHPOatp10genetic
22681890
PDX1_SCHPOsnz1genetic
22681890
RNC1_SCHPOrnc1genetic
22681890
ALG9_SCHPOalg9genetic
22681890
YK72_SCHPOSPAC732.02cgenetic
22681890
YG03_SCHPOSPBC1604.03cgenetic
22681890
PPK30_SCHPOppk30genetic
22681890
NAA35_SCHPOmak10genetic
22681890
YBPC_SCHPOSPBC16H5.12cgenetic
22681890
CHO2_SCHPOcho2genetic
22681890
PNK1_SCHPOpnk1genetic
22681890
HOSM_SCHPOlys4genetic
22681890
LSB5_SCHPOlsb5genetic
22681890
YJD1_SCHPOSPCC594.01genetic
22681890
YBLC_SCHPOSPBC106.12cgenetic
22681890
FRP1_SCHPOfrp1genetic
22681890
CYSK_SCHPOcys11genetic
22681890
RL27A_SCHPOrpl2701genetic
22681890
PIT1_SCHPOpit1genetic
22681890
ASK1_SCHPOask1genetic
22681890
TOM70_SCHPOtom70genetic
22681890
TBA2_SCHPOatb2genetic
22681890
RL9A_SCHPOrpl901genetic
22681890
PVH1_SCHPOSPBC17A3.06genetic
22681890
MAK1_SCHPOmak1genetic
22681890
YGK5_SCHPOSPBC725.05cgenetic
22681890
MUG73_SCHPOmug73genetic
22681890
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MAK3_SCHPO

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-12; SER-16 AND SER-17,AND MASS SPECTROMETRY.

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