RNC1_SCHPO - dbPTM
RNC1_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RNC1_SCHPO
UniProt AC O74919
Protein Name RNA-binding protein rnc1
Gene Name rnc1 {ECO:0000312|EMBL:CAA21234.1}
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 398
Subcellular Localization Cytoplasm .
Protein Description Binds and stabilizes pmp1 mRNA and hence acts as a negative regulator of pmk1 signaling. Overexpression suppresses the Cl(-) sensitivity of calcineurin deletion..
Protein Sequence MAYNHFSIPKNIEEKENSFFDVTFQDEPDETTSTATGIAKVSIPTPKPSTPLSTLTNGSTIQQSMTNQPEPTSQVPPISAKPPMDDATYATQQLTLRALLSTREAGIIIGKAGKNVAELRSTTNVKAGVTKAVPNVHDRVLTISGPLENVVRAYRFIIDIFAKNSTNPDGTPSDANTPRKLRLLIAHSLMGSIIGRNGLRIKLIQDKCSCRMIASKDMLPQSTERTVEIHGTVDNLHAAIWEIGKCLIDDWERGAGTVFYNPVSRLTQPLPSLASTASPQQVSPPAAPSTTSGEAIPENFVSYGAQVFPATQMPFLQQPKVTQNISIPADMVGCIIGRGGSKISEIRRTSGSKISIAKEPHDETGERMFTITGTHEENEKALFLLYQQLEMEKDRRSH
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
18PhosphorylationNIEEKENSFFDVTFQ
CHHHHHCCCEEEEEC		28.5125720772
23PhosphorylationENSFFDVTFQDEPDE
HCCCEEEEECCCCCC		19.8821712547
50PhosphorylationIPTPKPSTPLSTLTN
CCCCCCCCCCHHCCC		36.4528889911
165PhosphorylationIDIFAKNSTNPDGTP
HHHHHCCCCCCCCCC		28.9325720772
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RNC1_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RNC1_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RNC1_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SKH1_SCHPOpek1genetic
12931193
TPP1_SCHPOtpp1genetic
22681890
YAS2_SCHPOcsr102genetic
22681890
NU132_SCHPOnup132genetic
22681890
SVF1_SCHPOSPCC584.11cgenetic
22681890
SDS23_SCHPOsds23genetic
22681890
ILVB_SCHPOilv1genetic
22681890
SWI6_SCHPOswi6genetic
22681890
YEG5_SCHPOmga2genetic
22681890
PYP1_SCHPOpyp1genetic
22681890
RAV2_SCHPOrav2genetic
22681890
PROB_SCHPOSPAC17H9.13cgenetic
22681890
ARP6_SCHPOarp6genetic
22681890
NUP60_SCHPOnup60genetic
22681890
PDX1_SCHPOsnz1genetic
22681890
MED19_SCHPOrox3genetic
22681890
MAK3_SCHPOmak3genetic
22681890
PFA3_SCHPOpfa3genetic
22681890
YN8E_SCHPOSPBP35G2.14genetic
22681890
YEG9_SCHPOSPAC26H5.09cgenetic
22681890
ARP8_SCHPOarp8genetic
22681890
CCQ1_SCHPOccq1genetic
22681890
YE04_SCHPOSPAC17H9.04cgenetic
22681890
BST1_SCHPObst1genetic
22681890
CLR4_SCHPOclr4genetic
22681890
HRQ1_SCHPOhrq1genetic
22681890
CG121_SCHPOcgi121genetic
22681890
POP2_SCHPOpop2genetic
22681890
BUN62_SCHPObun62genetic
22681890
AATC_SCHPOSPAC10F6.13cgenetic
22681890
PPR2_SCHPOppr2genetic
22681890
RICTR_SCHPOste20genetic
22681890
GIT3_SCHPOgit3genetic
22681890
GSK3_SCHPOgsk3genetic
22681890
PAB2_SCHPOpab2genetic
22681890
MUG80_SCHPOmug80genetic
22681890
POM1_SCHPOpom1genetic
22681890
ARP42_SCHPOarp42genetic
22681890
NAA35_SCHPOmak10genetic
22681890
PHD1_SCHPOhos2genetic
22681890
SET3_SCHPOset3genetic
22681890
REC11_SCHPOrec11genetic
22681890
ASH2_SCHPOash2genetic
22681890
GBB_SCHPOgit5genetic
22681890
SSN3_SCHPOsrb10genetic
22681890
TLS1_SCHPOtls1genetic
22681890
YE98_SCHPOerp2genetic
22681890
TR112_SCHPOtrm112genetic
22681890
YFM8_SCHPOSPAC222.08cgenetic
22681890
LIZ1_SCHPOliz1genetic
22681890
YO48_SCHPOSPBC36B7.08cgenetic
22681890
AROG_SCHPOSPAP8A3.07cgenetic
22681890
YF75_SCHPOspa2genetic
22681890
CYB51_SCHPOSPBC29A10.16cgenetic
22681890
ELOF1_SCHPOSPAC1B3.02cgenetic
22681890
PPZ_SCHPOpzh1genetic
22681890
YIDH_SCHPOSPAC227.17cgenetic
22681890
YGVA_SCHPOdef1genetic
22681890
CLR3_SCHPOclr3genetic
22681890
ERD11_SCHPOerd1genetic
22681890
ASK1_SCHPOask1genetic
22681890
ALM1_SCHPOalm1genetic
22681890
YBPD_SCHPOSPBC16H5.13genetic
22681890
SHR3_SCHPOpsh3genetic
22681890
TOM70_SCHPOtom70genetic
22681890
PPID_SCHPOwis2genetic
22681890
YQ9A_SCHPOSPCC18.10genetic
22681890
YI75_SCHPOSPAC977.05cgenetic
22681890
DPH5_SCHPOdph5genetic
22681890
FFT3_SCHPOfft3genetic
22681890
TRM6_SCHPOgcd10genetic
22681890
DAD2_SCHPOdad2genetic
22681890
SDE2_SCHPOsde2genetic
22681890
LTN1_SCHPOrkr1genetic
22681890
H2AZ_SCHPOpht1genetic
22681890
GEF1_SCHPOgef1genetic
22681890
PDE1_SCHPOcgs2genetic
22681890
TIP1_SCHPOtip1genetic
22681890
WTF15_SCHPOwtf15genetic
22681890
YOH8_SCHPOleo1genetic
22681890
TFS2_SCHPOtfs1genetic
22681890
RL21B_SCHPOrpl2102genetic
22681890
PRZ1_SCHPOprz1genetic
22681890
MCL1_SCHPOmcl1genetic
22681890
NAA38_SCHPOnaa38genetic
22681890
OMH6_SCHPOomh6genetic
22681890
MAD1_SCHPOmad1genetic
22681890
PMP1_SCHPOpmp1physical
20692117
RNC1_SCHPOrnc1physical
23695164
RNC1_SCHPOrnc1physical
26771498
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RNC1_SCHPO

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Feedback regulation of MAPK signalling by an RNA-binding protein.";
Sugiura R., Kita A., Shimizu Y., Shuntoh H., Sio S.O., Kuno T.;
Nature 424:961-965(2003).
Cited for: FUNCTION, PHOSPHORYLATION AT THR-50, AND MUTAGENESIS OF THR-50;GLY-110; GLY-195 AND GLY-337.

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