dbPTM

TLS1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TLS1_SCHPO
UniProt AC	Q10148
Protein Name	Telomere length and silencing protein 1 {ECO:0000303\|PubMed:25245948}
Gene Name	tls1 {ECO:0000303\|PubMed:25245948}
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	254
Subcellular Localization	Cytoplasm . Nucleus .
Protein Description	Involved in the regulation of heterochromatin assembly at telomeric regions. Involved in the control of telomere length. Regulates spliceosome assembly by associating with brr2. Regulates the proper splicing of mRNAs of the shelterin components rap1 and poz1 to control telomeric heterochromatin assembly and telomere length..
Protein Sequence	MNSIHIKKKSNRSFRRRKVFGNEKEFDLEELDDNDIRLRQALEATKRRKIRNSIIGINAEKLLNQETKKEKQLNTANEPHEANDQTSAQSSKLIEAQLPTVEDRFAKQTNEVDINTHLLNFVEKKLKQERLAQNYSENGETNALNTKNESTVQNIKNSLHPNEHSFIRDAAALGAIREVDLGIISTDVDNLKNGRKRQKKRARMKEKLDSKALRTSEDAARDEFIEKMLKPISQDEESKGIYRRFRVYKDGTQD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
215	Phosphorylation	LDSKALRTSEDAARD HCHHHHHCCHHHHHH		29996109
216	Phosphorylation	DSKALRTSEDAARDE CHHHHHCCHHHHHHH		25720772

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TLS1_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TLS1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TLS1_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of TLS1_SCHPO !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TLS1_SCHPO

Related Literatures of Post-Translational Modification