| UniProt ID | GSK3_SCHPO | |
|---|---|---|
| UniProt AC | Q10452 | |
| Protein Name | Protein kinase gsk3 | |
| Gene Name | gsk3 | |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). | |
| Sequence Length | 387 | |
| Subcellular Localization | Cytoplasm . Nucleus . | |
| Protein Description | Interacts with cdc14 which is thought to play a role in the initiation and completion of mitosis. Involved in the positive regulation of mis12.. | |
| Protein Sequence | MNHGTKIPVDPFRIIKETARDGSTGEVKQLSYTSSKVVGSGSFGVVMQVHLIESDSKAAIKRVLQDKRFKNRELQIMRIMKHPNIVDLIAYYYTTGDNSDEVYLNLVLEFMPETIYRASRLYTRQKLSMPMLEVKLYIYQLLRSLAYIHASGICHRDIKPQNLLLDPENGILKLCDFGSAKILVAGEPNVSYICSRYYRAPELIFGATDYTHAIDIWSTGCVMAELMLGHPLFPGESGIDQLVEIIKILGTPSREQIKTMNPNYMEHRFPQIRPQPLSRVFSRSVPLDALDLLSKMLQYTPTDRLTAAEAMCHPFFDELRDPNTKLHNSRNPDASPRHLPELFNFSPFELSIRPDLNQKLIPSHARDALPVKLDDFVPIPIHRARID | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 191 | Phosphorylation | VAGEPNVSYICSRYY EECCCCHHHHHCCCC | 18.54 | 28889911 | |
| 192 | Phosphorylation | AGEPNVSYICSRYYR ECCCCHHHHHCCCCC | 11.15 | 28889911 | |
| 195 | Phosphorylation | PNVSYICSRYYRAPE CCHHHHHCCCCCCCH | 17.48 | 25720772 | |
| 284 | Phosphorylation | LSRVFSRSVPLDALD HHHHHCCCCCHHHHH | 27.21 | 25720772 | |
| 335 | Phosphorylation | NSRNPDASPRHLPEL CCCCCCCCCCCHHHH | 29.82 | 28889911 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 192 | Y | Phosphorylation | Kinase | GRK3 | - | GPS |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of GSK3_SCHPO !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of GSK3_SCHPO !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
| Phosphorylation | |
| Reference | PubMed |
| "Phosphoproteome analysis of fission yeast."; Wilson-Grady J.T., Villen J., Gygi S.P.; J. Proteome Res. 7:1088-1097(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-191 AND TYR-192, ANDMASS SPECTROMETRY. | |
| "Schizosaccharomyces pombe skp1+ encodes a protein kinase related tomammalian glycogen synthase kinase 3 and complements a cdc14cytokinesis mutant."; Plyte S.E., Feoktistova A., Burke J.D., Woodgett J.R., Gould K.L.; Mol. Cell. Biol. 16:179-191(1996). Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, INTERACTION WITH CDC14,MUTAGENESIS OF LYS-61; TYR-192 AND SER-335, AND PHOSPHORYLATION ATTYR-192 AND SER-335. | |
