| UniProt ID | ATG1_SCHPO | |
|---|---|---|
| UniProt AC | Q9Y7T4 | |
| Protein Name | Serine/threonine-protein kinase atg1 {ECO:0000312|PomBase:SPCC63.08c} | |
| Gene Name | atg1 {ECO:0000312|PomBase:SPCC63.08c} | |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). | |
| Sequence Length | 830 | |
| Subcellular Localization |
Cytoplasm. Preautophagosomal structure membrane Peripheral membrane protein. |
|
| Protein Description | Serine/threonine protein kinase involved in the cytoplasm to vacuole transport (Cvt) and found to be essential in autophagy, where it is required for the formation of autophagosomes. Involved in the clearance of protein aggregates which cannot be efficiently cleared by the proteasome. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Also involved in endoplasmic reticulum-specific autophagic process, in selective removal of ER-associated degradation (ERAD) substrates. Plays a key role in ATG9 and ATG23 cycling through the pre-autophagosomal structure and is necessary to promote ATG18 binding to ATG9 through phosphorylation of ATG9 (By similarity). Autophagy functions to supply nitrogen and is activated when cells cannot access exogenous nitrogen, thus ensuring that they can adapt and subsequently propagate. Finally, atg13 is also required for glycogen storage during stationary phase and has a role in meiosis and sporulation.. | |
| Protein Sequence | MNLQTSTNQTIGPYVIRSEIGRGSFAIVYKGKHTETNRVISIKSVLTKKLTKKLLENLESEISILKEIRHVHVVELIDCIKAGRFIHLVMEYCSLGDLSYFIRKREKFNSIPSLAWINIDHPPVYKAGLNETLVRHFTQQLASALQFLRSRSLIHRDVKPQNLLLQPPPTAAYLEEHPQFVGSPKLPMLKLADFGFARYLQTSSMAETLCGSPLYMAPEILRYEKYDAKADLWSVGAVLYEMAVGKPPFKAPNHVELLRRIQKAKDVIKFPEEAFIHPDIKTLICALLKQNPADRIDYDGFFSSIVVTTPLDDASTLTGSDIQDAVKEINIPSSSPAYITDFFPKSNPGAPAPPGGLLRQAFQAQGSSIQPSEITGRRVPHRYAQDGNTLPYTPVFPPESAPAASIFPPRLTSKQPIPMASPAKLTSDTSNKSSAYVVVDHHPIISSTQLSNESLTHEQSINGNSPSPNEGVFQGSFSPESAPVNNHAFPHTSRMQIPYMKPNAFPSNPTYIASTPVTQLRRAFEQATAHVPQSGGGARNKSALERALNVANARLNEVVVDGMTDNGNTSLPTKESNLDNNVNIIQPSLPDTGKRLLDVLESIAMKSNSVYHLAEVKLAQIIPSLSDEMKPGDTLLDRPLTPFSLVMLAKESYVLYERDIELLQVAFDGVAAFWANSEERASPDCQQAIEWFRQRYSESLEKSQFLREIIISQSAAHSLPTTKPVSASQLIYHRALDLSRNAATSELSGNDAQACLQNYRLAAHLLESLLESNFSTPDGANDSNNSVTIRNLIALITKRQELLQSKQIQANVANKVTESVAKITLAPNLA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 333 | Phosphorylation | VKEINIPSSSPAYIT HHHCCCCCCCCCEEE | 39.38 | 24763107 | |
| 334 | Phosphorylation | KEINIPSSSPAYITD HHCCCCCCCCCEEEC | 34.68 | 25720772 | |
| 335 | Phosphorylation | EINIPSSSPAYITDF HCCCCCCCCCEEECC | 20.21 | 25720772 | |
| 338 | Phosphorylation | IPSSSPAYITDFFPK CCCCCCCEEECCCCC | 14.03 | 25720772 | |
| 340 | Phosphorylation | SSSPAYITDFFPKSN CCCCCEEECCCCCCC | 17.68 | 29996109 | |
| 346 | Phosphorylation | ITDFFPKSNPGAPAP EECCCCCCCCCCCCC | 48.79 | 28889911 | |
| 367 | Phosphorylation | QAFQAQGSSIQPSEI HHHHHCCCCCCHHHC | 16.52 | 25720772 | |
| 368 | Phosphorylation | AFQAQGSSIQPSEIT HHHHCCCCCCHHHCC | 31.87 | 25720772 | |
| 400 | Phosphorylation | TPVFPPESAPAASIF CCCCCCCCCCHHHCC | 45.38 | 29996109 | |
| 427 | Phosphorylation | ASPAKLTSDTSNKSS CCCCCCCCCCCCCCC | 49.69 | 27738172 | |
| 534 | Phosphorylation | ATAHVPQSGGGARNK HHCCCCCCCCCCCCH | 33.08 | 29996109 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ATG1_SCHPO !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ATG1_SCHPO !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ATG1_SCHPO !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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