CCH1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CCH1_SCHPO
• UniProt AC: O14234
• Protein Name: Calcium-channel protein cch1
• Gene Name: cch1
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 1854
• Subcellular Localization: Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane ; Multi-pass membrane protein .
• Protein Description: Voltage-gated, high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones. Functions together with yam8 to ensure that adequate levels of Ca(2+) are supplied to pmr1 to sustain secretion and growth. Required for growth in low-calcium environments (By similarity)..
• Protein Sequence: MSSSSNSDPSSSPDNTDFIPLKDNPKDTSSYINKKNPFVNDSFDSHDDSYLDNVNPFEYNVADDEDTISMTSDGVEFHNLGITETVDEQDKILSELQLAYPTVSRYSETLDKGLLNGDKTTKGDYTSLRRFRKPFLFDKLSPYFTHFFSEIYAAVLRVVGPPRANETPGRNLPFSPILRQIYNHPLYNIFIFVVIVLHAVLLMIRSDDPHDKSQTIDYLIIVIGILYTLEMLLKIYLFGFLYDGSSSFYDFINSYTKKTPRTMSYLRHSWNRVDFVAIVALWISVIGKKQQGIFRLFSMIACLRLTRLLNITRKTETILKSLKESSTPLVQVVSFNAFFGVMIAILGVQFFKASLNRQCVWLGDYGDQYLPTGQFCGGHWENGIKRAYLDKNGFPSNVNPRGFICAEKSVCRVVENPYSNTVSFDNFFNSLELIFVIMSSNGFTDIMYDIMDAEYFVSCLLFIISAYFLTLWLMSLVIAVVTSSFIDLQHSGKNQKEQKSVDKHLIRNKLCEKYLFYSNFIWISFIVAQFVTLCTQTYDQTSSTANRYLIFYACVDFLLAAEVILRFFAYLPDYRLFFRRYTNLVDIVLAVLNLVTLLPSIRKNPVAFGWLSIFAIARIYRCILLIPYTRKIAKLLFSNFKQLLNLMLFLVIVLFIASLCAVRLFQDLPNDGDSDDDAISFATTYESFLYMYQILTSENWTDVMFAIQARLAHLHLSWIPGAFFTLWFLFSNNVVLSMFIAVIQVNFAPSESDLKMEQLKMYLARLLRNYNPFQASLTLNALIKRNGSRKGKTVDESHYEWLYEDNIIKGFLRVTNIPPKEPLKPSLDTSPELSKYSLAKLSNNFKRFVMRDDPFSQAYFKRVIGIRWEKDMNLKTAAKDMQAAKAFVRIKQTEFLKNHPKYNDVFWVIKPSNRIRRFCQRLVMPGVNERYGGVEPYQWVYRVIQVFIYACILTAVIIECIATPIYERDHLLNDKQHAWFVWTEVAFATIFTIEAAIKIIADGFCITPNAYLRSTWNCIDFFVLVTLWINLYAVLTSHALLSRAFRAFKALRVLRLINLTQTSQRMFHDALISGFFKIFSAAVVSATLLIPFALWAKNVFGGLLYSCNDDNVLSASQCVLEYASTPNNWEVWAPRVWSNPPDYDFDRFPHALLALFEIASIEGWVDIMRSVMDITGFNNQPQTNASSGNAMFFVLFNLVSMIYILTLFIAIIISNYAERTGSAFFTAEQRAWLELRRKIKSMRPSKRPAIRPLGLRGLCYDFAVQKHGIWRRTFTGLYIVHLLFLLTIFYPCPIAYTYVRNSIFLILSICYTINICVKVYGLSFYYFFHSFWNMFDVVVTLGSLTCNIAILAKFENRSLTLLQTTLLVLVTVHLIPKFDNFDQLSKTVVASLPSIFSLIATWIVLYITFAIAFNQIFGLTKLGLNGGPNKNFRSIRNALVLLFTMTFGEGWNDVMHDYTISYPNCVNGDDFYNSDCGNKPWAYGLFIAWNIISMYIFVNMFITVVFDNFSYIHTKSSSFTNLQRNDFRQFKDSWAPFDPMVTGYIPKRNAVKFVLSLRGVYDFRIYRDEHTLRSIISKVQSKTGQQSVPMLENPLMGSEINLEALDQIIDTIDVNVVKERRNVLNSLCTEIMTLPGNVISFSNILMLVVLHKIVDHREAFPISDYIRRAYVLSELEKSIRMEKLLGLVETSIIRKTFLQHMEEKKKALENPFILLSEVSEILPETPIQEVLRQHNADPEQLLMSTRTPSVSDRSFSIVESTVPTIASGEGDDNHSVEDHLKVPTDNEPRRSPSLKEVLLRGSHSLHSNNDRTSFDIEAGFGTAESDFQFGGATEDINRIADRIDDYLDRDSFKG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
102	Phosphorylation	ELQLAYPTVSRYSET HHHHHCHHHHHCCCH	20.59	21712547
1791	Phosphorylation	TDNEPRRSPSLKEVL CCCCCCCCCCHHHHH	21.81	25720772
1851	Phosphorylation	DDYLDRDSFKG---- HHHHHHHHCCC----	29.74	25720772

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CCH1_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CCH1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CCH1_SCHPO !!

Protein-Protein Interaction

Oops, there are no PPI records of CCH1_SCHPO !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.