| UniProt ID | EIF3E_SCHPO | |
|---|---|---|
| UniProt AC | O94513 | |
| Protein Name | Eukaryotic translation initiation factor 3 subunit E {ECO:0000255|HAMAP-Rule:MF_03004} | |
| Gene Name | int6 | |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). | |
| Sequence Length | 501 | |
| Subcellular Localization | Cytoplasm . | |
| Protein Description | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation (Potential). Required for maintaining the basal level of atf1 and for transcriptional activation of core environmental stress response genes (CESR genes) in response to histidine starvation. [PubMed: 18502752 May positively regulate proteasome activity] | |
| Protein Sequence | MGSELKSTSPLAVKYDLSQKIMQHLDRHLIFPLLEFLSLRQTHDPKELLQAKYDLLKDTNMTDYVANLWTNLHGGHTDEDMANAFAEKRRSVLQELSELEEEVQGILGVLENPDLIAALRQDKGQNLQHLQEHYNITPERIAVLYKFAQFQYNCGNYGGASDLLYHFRAFSKDPELNASATWGKFASEILTVDWDGAMEELGKLREMVDSKSFKDSAVQLRNRTWLLHWSLFPLFNHANGCDTLCDLFFYTPYLNTIQTSCPWLLRYLTVAVVTNQNNANQKPRNPRQSYQRRMRDLVRIISQENYEYSDPVTSFISALYTEVDFEKAQHCLRECEEVLKTDFFLVSLCDHFLEGARKLLAEAYCRIHSVISVDVLANKLEMDSAQLIQLVENRNNPSVAAASNVAADQSTEDESIESTSTNVVADDLITEAETATEAEEPEPEVQFGFKAKLDGESIIIEHPTYSAFQQIIDRTKSLSFESQNLEQSLAKSISELKHATV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 7 | Phosphorylation | -MGSELKSTSPLAVK -CCCCCCCCCCCCHH | 46.90 | 25720772 | |
| 8 | Phosphorylation | MGSELKSTSPLAVKY CCCCCCCCCCCCHHC | 32.54 | 25720772 | |
| 9 | Phosphorylation | GSELKSTSPLAVKYD CCCCCCCCCCCHHCC | 25.63 | 28889911 | |
| 212 | Phosphorylation | REMVDSKSFKDSAVQ HHHHHCCCHHHHHHH | 41.29 | 25720772 | |
| 475 | Phosphorylation | FQQIIDRTKSLSFES HHHHHHHHHCCCCCC | 22.64 | 25720772 | |
| 477 | Phosphorylation | QIIDRTKSLSFESQN HHHHHHHCCCCCCCC | 28.74 | 28889911 | |
| 479 | Phosphorylation | IDRTKSLSFESQNLE HHHHHCCCCCCCCHH | 33.78 | 28889911 | |
| 482 | Phosphorylation | TKSLSFESQNLEQSL HHCCCCCCCCHHHHH | 23.51 | 25720772 | |
| 500 | Phosphorylation | ISELKHATV------ HHHHHHCCC------ | 26.85 | 25720772 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of EIF3E_SCHPO !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of EIF3E_SCHPO !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of EIF3E_SCHPO !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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