EIF3M_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EIF3M_SCHPO
• UniProt AC: Q09722
• Protein Name: Eukaryotic translation initiation factor 3 subunit M {ECO:0000255|HAMAP-Rule:MF_03012}
• Gene Name: eif3m
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 402
• Subcellular Localization: Cytoplasm .
• Protein Description: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation..
• Protein Sequence: MEGSDFILVVDSSVEEQVEELAMYLDNLEANTDKNVLALCREYLASENVKEVLNLFLTRLPLLAQAPEKELEPILAVFINLIQESAAFEDHVSKFCQALEQIADQNNNLTPAILSVLSILFNTAVKERQHARLSILTSVVTLTTRYSLFSTLAPNLKYFPDWLKEAGVSVSDHRAFNIFVSKAIQSYDDEQSFAFLLEAVKMDNSTADEAVRELVQRAVNSPKYFFFDDIVTLPPVQQLEQSTLQLLGILSGGMTDDYVSWVAENHAHCQHQKFDEDAIARKMKLLTIASLATQAPNNTLSYGDVAKSLKIDENEVELWIIDVIRAGLVEGRMSQLTKTLSIHRSSYRVFGKHEWVALHEKLAKWGSSLRYMLQVMEQPLSSFTIASSKKGNRDGSAVTASE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
396	Phosphorylation	KKGNRDGSAVTASE- CCCCCCCCCEECCC-	24.69	21712547
399	Phosphorylation	NRDGSAVTASE---- CCCCCCEECCC----	24.96	21712547
401	Phosphorylation	DGSAVTASE------ CCCCEECCC------	34.18	24763107

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EIF3M_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EIF3M_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EIF3M_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EIF3A_SCHPO	tif32	physical	15904532
EIF3B_SCHPO	SPAC25G10.08	physical	15904532
EIF3C_SCHPO	tif33	physical	15904532
EIF3H_SCHPO	SPAC821.05	physical	15904532
EIF3I_SCHPO	sum1	physical	15904532
EIF3F_SCHPO	SPBC4C3.07	physical	15904532
RPN1_SCHPO	mts4	physical	19818717

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.