| UniProt ID | CUT8_SCHPO | |
|---|---|---|
| UniProt AC | P38937 | |
| Protein Name | Tethering factor for nuclear proteasome cut8 | |
| Gene Name | cut8 | |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). | |
| Sequence Length | 262 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Involved in ubiquitin-mediated protein degradation. Regulatory factor in the ubiquitin/proteasome pathway that controls the turnover of proteasome substrates. Targets proteasomes to the nucleus and facilitates the degradation of nuclear proteins like mitotic cyclin and cut2. Required for normal progression of anaphase.. | |
| Protein Sequence | METLSYSQIKKRKADFDEDISKRARQLPVGEQLPLSRLLQYSDKQQLFTILLQCVEKHPDLARDIRGILPAPSMDTCVETLRKLLINLNDSFPYGGDKRGDYAFNRIREKYMAVLHALNDMVPCYLPPYSTCFEKNITFLDAATNVVHELPEFHNPNHNVYKSQAYYELTGAWLVVLRQLEDRPVVPLLPLEELEEHNKTSQNRMEEALNYLKQLQKNEPLVHERSHTFQQTNPQNNFHRHTNSMNIGNDNGMGWHSMHQYI | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|
|---|---|---|---|---|---|---|
Oops, there are no PTM records of CUT8_SCHPO !! | ||||||
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CUT8_SCHPO !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CUT8_SCHPO !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CUT8_SCHPO !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| SECU_SCHPO | cut2 | genetic | 11084332 | |
| CEK1_SCHPO | cek1 | genetic | 8065367 | |
| CUT1_SCHPO | cut1 | genetic | 12653962 | |
| SECU_SCHPO | cut2 | genetic | 12653962 | |
| APC1_SCHPO | cut4 | genetic | 11084332 | |
| CUT9_SCHPO | cut9 | genetic | 11084332 | |
| SLP1_SCHPO | slp1 | genetic | 11084332 | |
| RPN12_SCHPO | rpn12 | genetic | 11084332 | |
| PP11_SCHPO | dis2 | genetic | 11084332 | |
| SECU_SCHPO | cut2 | genetic | 15507118 | |
| RAD18_SCHPO | rhp18 | genetic | 16096059 | |
| SLX1_SCHPO | slx1 | genetic | 17178839 | |
| RPN12_SCHPO | rpn12 | physical | 16096059 | |
| RPN11_SCHPO | rpn11 | physical | 16096059 | |
| RPN1_SCHPO | mts4 | physical | 16096059 | |
| CUT8_SCHPO | cut8 | physical | 21976488 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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