dbPTM

RPN11_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RPN11_SCHPO
UniProt AC	P41878
Protein Name	26S proteasome regulatory subunit rpn11
Gene Name	rpn11
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	308
Subcellular Localization
Protein Description	Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.; Transcription factor pap1 is controlled by the functional interaction between the positive regulator pad1 and negative regulator crm1. Both these proteins are also essential for cell viability and for the maintenance of chromosome structure. Pad1 is also responsible for resistance to staurosporine, and other drugs such as cycloheximide and caffeine..
Protein Sequence	MESLQRLLQGARMGTGMMGDQPLVDNSECVYISSLALLKMLRHGRHGTPMEVMGLMLGEFVDDFTVRVVDVFAMPQSGTGVSVEAVDPVFQKNMMDMLKQTGRPEMVVGWYHSHPGFGCWLSSVDINTQQSFEQLTPRAVAVVVDPIQSVKGKVVIDAFRLINPSTLMMGQEPRQTTSNLGHINKPSIQALIHGLGRHYYSLRINYKKTELEEIMLLNLHKQPWAHGLLLENFNSAAEKNHASIDKMKSLSEQYTERVQNEVTLSPEQLRIQYVGKQDPKKHLDAEVQKCIDNNISSMLACMLDSVAF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
263	Phosphorylation	ERVQNEVTLSPEQLR HHHHHCCCCCHHHHH	18.49	29996109
265	Phosphorylation	VQNEVTLSPEQLRIQ HHHCCCCCHHHHHEE	19.61	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RPN11_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RPN11_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RPN11_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RPN12_SCHPO	rpn12	genetic	9727008
RPN1_SCHPO	mts4	genetic	9727008
AP1_SCHPO	pap1	genetic	9532803
RPN1_SCHPO	mts4	physical	9822592
UBLH2_SCHPO	uch2	physical	15533439
RPN1_SCHPO	mts4	physical	9727008
RPN3_SCHPO	rpn3	physical	20838651
RPN6_SCHPO	rpn6	physical	20838651
RPN7_SCHPO	rpn7	physical	20838651
RPN2_SCHPO	rpn2	physical	20838651
RPN1_SCHPO	mts4	physical	20838651
RPN9_SCHPO	rpn9	physical	20838651
PRS10_SCHPO	rpt4	physical	20838651
PRS8_SCHPO	rpt6	physical	20838651
RPN8_SCHPO	rpn8	physical	20838651
PRS7_SCHPO	rpt1	physical	20838651
PRS6A_SCHPO	rpt5	physical	20838651
PRS6B_SCHPO	rpt3	physical	20838651
PRS4_SCHPO	rpt2	physical	20838651
PSB1_SCHPO	pre3	physical	20838651
PSA1_SCHPO	scl1	physical	20838651
PSB5_SCHPO	pts1	physical	20838651
PSA5_SCHPO	pup2	physical	20838651
RPN12_SCHPO	rpn12	physical	20838651
PSA4_SCHPO	pre6	physical	20838651
PSA2_SCHPO	pre8	physical	20838651
PSB6_SCHPO	pam1	physical	20838651
PSA6_SCHPO	pre5	physical	20838651
PSB7_SCHPO	pre4	physical	20838651
PSB2_SCHPO	pup1	physical	20838651
PSA3_SCHPO	pre9	physical	20838651
RPN10_SCHPO	rpn10	physical	20838651
UBLH2_SCHPO	uch2	physical	20838651
YOY4_SCHPO	rpn1301	physical	20838651
PSA7_SCHPO	pre10	physical	20838651
ADRM1_SCHPO	rpn1302	physical	20838651
PSB4_SCHPO	pre1	physical	20838651
PSB3_SCHPO	pup3	physical	20838651
ECM29_SCHPO	ecm29	physical	20838651
PRS6B_SCHPO	rpt3	physical	22307589
RPN3_SCHPO	rpn3	physical	22307589
AP1_SCHPO	pap1	genetic	23209828
BDC1_SCHPO	bdc1	physical	26771498

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RPN11_SCHPO

Related Literatures of Post-Translational Modification