dbPTM

PSA2_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PSA2_SCHPO
UniProt AC	O94579
Protein Name	Probable proteasome subunit alpha type-2
Gene Name	pre8
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	245
Subcellular Localization	Cytoplasm . Nucleus .
Protein Description	The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity)..
Protein Sequence	MTDKYAFSLTTFSPNGKLVQIEYALNAVNAGVTSVGIKATDGVVLATEKKPTSELAIGASLEKVCAITPDIGMVYSGMGPDFRVLVDKSRKVAQTTYKKIYNEYPPTKILVQEIASVMQESTQSGGVRPFGVSLLVAGMDEKGPSLYQVDPSGTYFAWKATAIGKSSTAAKTFLEKRYNDELELDDAVHTAILALKETFEGELTEDNIEIAVVSTKPTDSGIVGVPGGHFCRLSQSEIRDYLDQV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	DKYAFSLTTFSPNGK CCEEEEEEEECCCCC	25.29	24763107
11	Phosphorylation	KYAFSLTTFSPNGKL CEEEEEEEECCCCCE	27.66	29996109
13	Phosphorylation	AFSLTTFSPNGKLVQ EEEEEEECCCCCEEE	18.50	21712547
234	Phosphorylation	GGHFCRLSQSEIRDY CCCEEECCHHHHHHH	16.59	25720772
236	Phosphorylation	HFCRLSQSEIRDYLD CEEECCHHHHHHHHH	31.45	25720772

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PSA2_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PSA2_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PSA2_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
PRS8_SCHPO	rpt6	physical	22307589
PSA3_SCHPO	pre9	physical	22307589

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PSA2_SCHPO

Related Literatures of Post-Translational Modification