RPN8_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RPN8_SCHPO
• UniProt AC: O74440
• Protein Name: 26S proteasome regulatory subunit rpn8
• Gene Name: rpn8
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 324
• Protein Description: Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins..
• Protein Sequence: MPPAVSSETSTIVPQQVIVHPLVLLSAVDSYNRSAKGTKRRVVGILLGQNNGDVVNVANSYAIPFEEDEKNASVWFLDHNFMESMNEMFKKINANEKLVGWYHTGPQLRPSDLEINNLLKKYIPNPVLVIIDVKPKSVGLPTNAYFAIDEIEDDGSKSSRTFVHLPSSIEAEEAEEIGVEHLLRDTRDASVGTLATRVTQQAQSLQGLGQRLTEIADYLRKVVDGQLPINHAILAELQSVFNLLPNIFSGPVVSEQALESEAQRAFNVNSNDQLMSIYISSIVRAVIALHDLLDSLAASKAMEQQDIKPTVQNGEVSANAEQKA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MPPAVSSETSTIV --CCCCCCCCCCCCC	25.27	29996109
137	Phosphorylation	IIDVKPKSVGLPTNA EEECCCCCCCCCCCE	29.91	25720772
190	Phosphorylation	LRDTRDASVGTLATR HHHCCCCCHHHHHHH	25.93	28889911
193	Phosphorylation	TRDASVGTLATRVTQ CCCCCHHHHHHHHHH	15.86	25720772
196	Phosphorylation	ASVGTLATRVTQQAQ CCHHHHHHHHHHHHH	28.87	25720772

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RPN8_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RPN8_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RPN8_SCHPO !!

Protein-Protein Interaction

Oops, there are no PPI records of RPN8_SCHPO !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.