CEK1_SCHPO - dbPTM
CEK1_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CEK1_SCHPO
UniProt AC P38938
Protein Name Serine/threonine-protein kinase cek1
Gene Name cek1
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 1338
Subcellular Localization
Protein Description May facilitate the progression of anaphase through direct or indirect interaction with the cut8 protein..
Protein Sequence MKHIKNEREEVFLEDDQAQHSQAELLSSKDENLQPSIPLSPVAFELDFSGNFQFISDNSSELLDIPKDKIIGHSVAEVLGTDGYNAFMRAVNCLLKDDSHSYHVRFQHSINANHANQNYYTAKGDLPSDEKITKPFDAIGILIRHPGSAIPAHTMWVVNPATNSLGSVSPLVTKLLDVIGFGASLLDKYLCDLRTSYHKHNSLDALPLPTPEFCQICEREIQSWFFELHSKFCLSTSTYESVVQAAQDSLLYFRSTLLEIQEGMQKDSSLVPVYKNEPLIVDADDYFFTDENKQTLSLCSFLSQVMYYLEVAIDITIPPVKIIVNFDKVDSLRVQSPRSEKATIELDNYNPSLENCSSAVIALWEDIKTAVDTKITGVLRLRNAIYYSERIRLEIDHHVQEIIDDVVSNLVTNHSSTSLGHLESKLAPSITFPDACDALEAEECITRPGSATNTPQSDRSLDINDLSRSSSYSRHLSHVSLSNPDFAIGSPMSQDSSNYSSPLHRRKASDSNFSDPRFDDLKYLSPNSSPRFVASDGPNRPASNGRSSLFSRGRASNLGDVGLRLPSPSPRIHTIVPNSAPEHPSINDYKILKPISKGAFGSVYLAQKRTTGDYFAIKILKKSNMIAKNQVINVRAERAILMSQGESPFVAKLYYTFQSKDYLYLVMEYLNGGDCGSLLKTMGVLDLDWIRTYIAETVLCLGDLHDRGIIHRDIKPENLLISQNGHLKLTDFGLSRVGYMKRHRRKQSSSIPVLDLRDRSSAISDLSLSTASSVLEAQSLITPERPKRPSLNEKLLSLDGTSIRLAGQSFNYENSAEDSPTATNTPTSQVDESNIFRSTDSPRVQPFFENKDPSKRFIGTPDYIAPEVILGNPGIKASDWWSLGCVVFEFLFGYPPFNAETPDQVFQNILARRINWPAEVFTAESSVALDLIDRLLCMNPANRLGANGVEEIKAHPFFKSVNWDTILEEDPPFVPKPFSPEDTVYFDSRGLKGFDFSEYYNQPTVTEAQKLEEERPASSIPQHVSGNRKGRLRSNTISTPEFGSFTYRNLDFLNKANRNTIQKLRKEHMAVKSAKTSVDDTFSQYMSRFKAKLSTSQSVGPVKSSRRASMADYEASTTTRVQDITTDSIDSIDDFDSLKEGRMLSFFDNLALEDHKGVSSTMSASQSQSSMHTALPDVTEGTSSDEHTTIQKGRIDNLQAQSLTHKRNAISYPGLFQLDRLQMIIPKDEIELAEILKKIFPKLTLVLIDDPWSILKKLLQNEQFNVVFLHFGNDKVSSSRLMYSVRTSATINSRVPFVYICEDETCIPTDLQSDGVLLKPITCENIESCLRKLDVWHS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
331PhosphorylationVNFDKVDSLRVQSPR
EECCCCCEEEECCCC		22.5121712547
336PhosphorylationVDSLRVQSPRSEKAT
CCEEEECCCCCCCCE		21.3024763107
339PhosphorylationLRVQSPRSEKATIEL
EEECCCCCCCCEEEE		47.0021712547
460PhosphorylationNTPQSDRSLDINDLS
CCCCCCCCCCHHHHC		35.0728889911
467PhosphorylationSLDINDLSRSSSYSR
CCCHHHHCCCCCCHH		32.7425720772
469PhosphorylationDINDLSRSSSYSRHL
CHHHHCCCCCCHHHH		21.9125720772
470PhosphorylationINDLSRSSSYSRHLS
HHHHCCCCCCHHHHC		31.9925720772
471PhosphorylationNDLSRSSSYSRHLSH
HHHCCCCCCHHHHCC		28.5125720772
509PhosphorylationPLHRRKASDSNFSDP
CCCCCCCCCCCCCCC		44.6121712547
511PhosphorylationHRRKASDSNFSDPRF
CCCCCCCCCCCCCCC		36.9625720772
514PhosphorylationKASDSNFSDPRFDDL
CCCCCCCCCCCCCCC		51.4624763107
523PhosphorylationPRFDDLKYLSPNSSP
CCCCCCCCCCCCCCC		21.5129996109
525PhosphorylationFDDLKYLSPNSSPRF
CCCCCCCCCCCCCCE		20.9528889911
528PhosphorylationLKYLSPNSSPRFVAS
CCCCCCCCCCCEECC		45.1429996109
529PhosphorylationKYLSPNSSPRFVASD
CCCCCCCCCCEECCC		27.0829996109
556PhosphorylationLFSRGRASNLGDVGL
HHCCCCCCCCCCCCC		31.0929996109
567PhosphorylationDVGLRLPSPSPRIHT
CCCCCCCCCCCCEEE		42.4728889911
569PhosphorylationGLRLPSPSPRIHTIV
CCCCCCCCCCEEEEC		31.0229996109
748PhosphorylationKRHRRKQSSSIPVLD
HHHCCCCCCCCCEEC		29.1428889911
749PhosphorylationRHRRKQSSSIPVLDL
HHCCCCCCCCCEECC		29.7725720772
750PhosphorylationHRRKQSSSIPVLDLR
HCCCCCCCCCEECCC		35.8429996109
790PhosphorylationPERPKRPSLNEKLLS
CCCCCCCCCCHHHHC		48.1124763107
819PhosphorylationYENSAEDSPTATNTP
CCCCCCCCCCCCCCC		18.6927738172
821PhosphorylationNSAEDSPTATNTPTS
CCCCCCCCCCCCCCC		50.4925720772
823PhosphorylationAEDSPTATNTPTSQV
CCCCCCCCCCCCCCC		41.9427738172
1034PhosphorylationNRKGRLRSNTISTPE
CCCCCCCCCCCCCCC		42.8129996109
1036PhosphorylationKGRLRSNTISTPEFG
CCCCCCCCCCCCCCC		19.9729996109
1109PhosphorylationVKSSRRASMADYEAS
CCCCCCHHHCHHHCC		16.8225720772
1128PhosphorylationVQDITTDSIDSIDDF
EEECCCCCCCCCCCH		26.6325720772
1131PhosphorylationITTDSIDSIDDFDSL
CCCCCCCCCCCHHHC		26.6725720772
1211PhosphorylationTHKRNAISYPGLFQL
CCCCCCCCCCCCCHH		23.9028889911
1212PhosphorylationHKRNAISYPGLFQLD
CCCCCCCCCCCCHHH		8.6625720772
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CEK1_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CEK1_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CEK1_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MU122_SCHPOmug122genetic
22681890
SWD3_SCHPOswd3genetic
22681890
DBR1_SCHPOdbr1genetic
22681890
SNF5_SCHPOsnf5genetic
22681890
RL27A_SCHPOrpl2701genetic
22681890
PEF1_SCHPOpef1physical
23874875
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CEK1_SCHPO

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-525; SER-748 ANDSER-1211, AND MASS SPECTROMETRY.

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