SLP1_SCHPO - dbPTM
SLP1_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SLP1_SCHPO
UniProt AC P78972
Protein Name WD repeat-containing protein slp1
Gene Name slp1
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 488
Subcellular Localization
Protein Description Required for mad2-dependent spindle checkpoint activation. Promotes ubiquitin-dependent degradation of cdc13 by the anaphase promoting complex/cyclosome (APC/C)..
Protein Sequence MEIAGNSSTISPTFSTPTKKRNLVFPNSPITPLHQQALLGRNGRSSKRCSPKSSFIRNSPKIDVVNTDWSIPLCGSPRNKSRPASRSDRFIPSRPNTANAFVNSISSDVPFDYSESVAEACGFDLNTRVLAFKLDAPEAKKPVDLRTQHNRPQRPVVTPAKRRFNTTPERVLDAPGIIDDYYLNLLDWSNLNVVAVALERNVYVWNADSGSVSALAETDESTYVASVKWSHDGSFLSVGLGNGLVDIYDVESQTKLRTMAGHQARVGCLSWNRHVLSSGSRSGAIHHHDVRIANHQIGTLQGHSSEVCGLAWRSDGLQLASGGNDNVVQIWDARSSIPKFTKTNHNAAVKAVAWCPWQSNLLATGGGTMDKQIHFWNAATGARVNTVDAGSQVTSLIWSPHSKEIMSTHGFPDNNLSIWSYSSSGLTKQVDIPAHDTRVLYSALSPDGRILSTAASDENLKFWRVYDGDHVKRPIPITKTPSSSITIR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
7Phosphorylation-MEIAGNSSTISPTF
-CCCCCCCCCCCCCC		28.1329996109
13PhosphorylationNSSTISPTFSTPTKK
CCCCCCCCCCCCCCC		24.3529996109
28PhosphorylationRNLVFPNSPITPLHQ
CCCCCCCCCCCHHHH		20.2329996109
31PhosphorylationVFPNSPITPLHQQAL
CCCCCCCCHHHHHHH		24.1529996109
59PhosphorylationKSSFIRNSPKIDVVN
CHHHCCCCCCCCEEC		20.0924763107
67PhosphorylationPKIDVVNTDWSIPLC
CCCCEECCCCCCCCC		27.5129996109
70PhosphorylationDVVNTDWSIPLCGSP
CEECCCCCCCCCCCC		19.6921712547
76PhosphorylationWSIPLCGSPRNKSRP
CCCCCCCCCCCCCCC		21.4921712547
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SLP1_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SLP1_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SLP1_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CUT1_SCHPOcut1genetic
12653962
SECU_SCHPOcut2genetic
12653962
RAD3_SCHPOrad3genetic
9001228
WEE1_SCHPOwee1genetic
9001228
CDK1_SCHPOcdc2genetic
9001228
MPIP_SCHPOcdc25genetic
9001228
CDR1_SCHPOcdr1genetic
9001228
CDR2_SCHPOcdr2genetic
9001228
CUT9_SCHPOcut9genetic
9001228
GRT1_SCHPOgrt1genetic
11058086
WEE1_SCHPOwee1genetic
11058086
SRW1_SCHPOsrw1genetic
11058086
MAD2_SCHPOmad2physical
11950879
MAD2_SCHPOmad2physical
9461438
VTS1_SCHPOSPBC13E7.03cgenetic
22681890
DAD2_SCHPOdad2genetic
22681890
CUT9_SCHPOcut9physical
11058086
MAD2_SCHPOmad2genetic
11058086
UBP8_SCHPOubp8genetic
24948786
SECU_SCHPOcut2physical
21389117
CG23_SCHPOcdc13physical
21389117
MES1_SCHPOmes1physical
21389117
MAD2_SCHPOmad2physical
27664031
SLP1_SCHPOslp1physical
28366743
MAD2_SCHPOmad2physical
28366743
MAD3_SCHPOmad3physical
28366743
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SLP1_SCHPO

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Related Literatures of Post-Translational Modification

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