SRW1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SRW1_SCHPO
• UniProt AC: O13286
• Protein Name: WD repeat-containing protein srw1
• Gene Name: srw1
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 556
• Subcellular Localization: Nucleus .
• Protein Description: Has a role in cell differentiation and cell cycling by negatively regulating cig2 and cdc12-associated cdc2. Down-regulates the level of cdc13, particularly in a nitrogen deprived environment. Regulator of cell cycle G1 phase progression. Prevents onset of mitosis during the pre-Start G1 period. Required for degradation of cdc13 mitotic cyclin B during G1 arrest but not during mitotic exit..
• Protein Sequence: MDEFDGFTRPTSSNSSANRNSNNSMNRVENNNSNSDSANTVDSRGDAHTRMRQGFEKSFPSSPNKKRPRTNEGDRFIPSRDASTELWTGFTKVEGPLTPVKKKQSVADRNFTTLLRSELFGSNDETFNNSPIATPNTTIGVSTPRTDSGIDDIELTQRTPPSSSHTSSSILQNTPVTPSRKIFHYLSPRDRNKSSYGKKAQYQDNPNRTIYSLSPVRSITKDLISASRLEGRELPSIPYRVLDAPGLAGDFYLNLLDWGQCNMLAVALASRVYLWSGISSEVTVMHNFYPTDTVTSLRWVQRGTHLAVGTHNGSVEIWDAATCKKTRTMSGHTERVGALSWNDHVLSSGGRDNHILHRDVRAPEHYFRVLTAHRQEVCGLEWNSNENLLASGGNDNALMVWDKFEEKPLYSFHNHIAAVKAITWSPHQRGILASGGGTADRTIKLWNTQRGSMLHNIDTGSQVCNLLWSKQTNEFISTHGFMENEVALWNYPSVSRVGTLKGHTDRVLYLAMSPNGENIVTGAADETLRFWKLFDSKSKHSASTMSSPFDPTMKIR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
62	Phosphorylation	FEKSFPSSPNKKRPR HHHHCCCCCCCCCCC	32.50	10921878
98	Phosphorylation	TKVEGPLTPVKKKQS CEEECCCCCCCCCCC	29.21	10921878
177	Phosphorylation	ILQNTPVTPSRKIFH HHCCCCCCCCHHHEE	19.42	10921878
185	Phosphorylation	PSRKIFHYLSPRDRN CCHHHEEECCCCCCC	9.72	25720772
187	Phosphorylation	RKIFHYLSPRDRNKS HHHEEECCCCCCCCC	15.66	28889911
212	Phosphorylation	NPNRTIYSLSPVRSI CCCCEEEECCCCHHH	20.65	25720772
214	Phosphorylation	NRTIYSLSPVRSITK CCEEEECCCCHHHHH	18.53	10921878
218	Phosphorylation	YSLSPVRSITKDLIS EECCCCHHHHHHHHH	34.54	24763107
220	Phosphorylation	LSPVRSITKDLISAS CCCCHHHHHHHHHHH	21.54	25720772

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SRW1_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SRW1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SRW1_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
WEE1_SCHPO	wee1	genetic	9571240
RUM1_SCHPO	rum1	genetic	9571240
CDK1_SCHPO	cdc2	genetic	14985109
CG23_SCHPO	cdc13	genetic	14985109
WEE1_SCHPO	wee1	genetic	9398669
CDK1_SCHPO	cdc2	genetic	9398669
CG23_SCHPO	cdc13	genetic	9398669
AMS2_SCHPO	ams2	physical	23195958
CG22_SCHPO	cig2	genetic	9571240
CDC10_SCHPO	cdc10	genetic	9571240
CG22_SCHPO	cig2	genetic	9398669
SECU_SCHPO	cut2	physical	21389117
CG23_SCHPO	cdc13	physical	21389117
MES1_SCHPO	mes1	physical	21389117
SRW1_SCHPO	srw1	physical	26771498
CG23_SCHPO	cdc13	physical	26771498

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-187, AND MASSSPECTROMETRY.
PubMed: 18257517

"Fission yeast Fizzy-related protein srw1p is a G(1)-specific promoterof mitotic cyclin B degradation.";
Yamaguchi S., Okayama H., Nurse P.;
EMBO J. 19:3968-3977(2000).
Cited for: FUNCTION, PHOSPHORYLATION AT SER-62; THR-98; THR-177 AND SER-214, ANDMUTAGENESIS OF SER-62; THR-98; THR-177 AND SER-214.
PubMed: 10921878