| UniProt ID | CG22_SCHPO | |
|---|---|---|
| UniProt AC | P36630 | |
| Protein Name | G2/mitotic-specific cyclin cig2 | |
| Gene Name | cig2 | |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). | |
| Sequence Length | 411 | |
| Subcellular Localization | Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. | |
| Protein Description | Essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transition. Interacts with the cdc2 protein kinase to form MPF. Interaction with res2 promotes the phosphorylation of res1 and inhibits MBF-dependent gene transcription. Forms an autoregulating feedback-inhibition loop with MBF which is important for normal regulation of the cell cycle. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis. Negatively regulates conjugation via interacting with cell cycle 'start' genes. Degraded by skp1, pop1 and pop2 in the G2 and M phases of the cell cycle.. | |
| Protein Sequence | MALYSISKPVGSKINKHSYQDENTLVGKQALSKGTEKTKLSTNFEINLPRRTVLSDVSNVGKNNADEKDTKKAKRSFDESNLSTNEEADKPVESKFVKKLKVYSKNADPSVETLQKDRVSNVDDHLSSNPLMAEEYAPEIFEYIRKLDLKCLPNPKYMDQQKELTWKMREILNEWLVEIHSNFCLMPETLYLAVNIIDRFLSRRSCSLSKFQLTGITALLIASKYEEVMCPSIQNFVYMTDGAFTVEDVCVAERYMLNVLNFDLSYPSPLNFLRKISQAEGYDAQTRTLGKYLTEIYLFDHDLLRYPMSKIAAAAMYLSRRLLRRGPWTPKLVESSGGYEEHELKEIAYIMLHYHNKPLEHKAFFQKYSSKRFLKASIFVHQLVRQRYSVNRTDDDDLQSEPSSSLTNDGH | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CG22_SCHPO !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CG22_SCHPO !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CG22_SCHPO !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| RUM1_SCHPO | rum1 | genetic | 10679013 | |
| RUM1_SCHPO | rum1 | genetic | 11163211 | |
| RUM1_SCHPO | rum1 | genetic | 10388806 | |
| RUM1_SCHPO | rum1 | physical | 9614176 | |
| CDK1_SCHPO | cdc2 | physical | 11163211 | |
| PUC1_SCHPO | puc1 | genetic | 10982385 | |
| CGP1_SCHPO | pas1 | genetic | 10982385 | |
| PUC1_SCHPO | puc1 | genetic | 10679013 | |
| NUP60_SCHPO | nup60 | genetic | 22681890 | |
| IES4_SCHPO | ies4 | genetic | 22681890 | |
| ULP2_SCHPO | ulp2 | genetic | 22681890 | |
| HHP2_SCHPO | hhp2 | genetic | 22681890 | |
| YB22_SCHPO | SPBC31F10.02 | genetic | 22681890 | |
| ALM1_SCHPO | alm1 | genetic | 22681890 | |
| MUG62_SCHPO | mug62 | genetic | 22681890 | |
| YK42_SCHPO | tos4 | genetic | 22681890 | |
| YOX1_SCHPO | yox1 | genetic | 22681890 | |
| PUC1_SCHPO | puc1 | genetic | 25891897 | |
| CRS1_SCHPO | crs1 | genetic | 25891897 | |
| RES2_SCHPO | res2 | genetic | 25533348 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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