CDR1_SCHPO - dbPTM
CDR1_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CDR1_SCHPO
UniProt AC P07334
Protein Name Mitosis inducer protein kinase cdr1
Gene Name cdr1
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 593
Subcellular Localization
Protein Description This protein, a dose-dependent mitotic inducer, appears to function as a negative regulator of mitosis inhibitor wee1 by phosphorylating and inactivating it..
Protein Sequence MVKRHKNTIGVWRLGKTLGTGSTSCVRLAKHAKTGDLAAIKIIPIRYASIGMEILMMRLLRHPNILRLYDVWTDHQHMYLALEYVPDGELFHYIRKHGPLSEREAAHYLSQILDAVAHCHRFRFRHRDLKLENILIKVNEQQIKIADFGMATVEPNDSCLENYCGSLHYLAPEIVSHKPYRGAPADVWSCGVILYSLLSNKLPFGGQNTDVIYNKIRHGAYDLPSSISSAAQDLLHRMLDVNPSTRITIPEVFSHPFLMGCTSLSSMDSTTPPTPSLSIDEIDPLVVDCMCVLWKKSSSKKVVRRLQQRDDNDEKYVYKVLSEILRDDMLKKQRFDENKYLSLYDLIHDNNLFTKASISTTSLVKSNVSTNSRKSSNFEDELARRVSSPLSALNQMSQSPIPIRVSSDKDYDSYACHEVVSNPSTLDDDYNYMFVCPPEEYTYSTDNVRTDSLDLQSLPTPTLEQLESVPFNRYGYVRIFPSTTLSSTASGYYTPDSLSTPEPSIDGLTNLDDVQVGGFVQGSGNQNRRPISFPVISNMQPNITNVRSASAPLCSSPVPSRRYSQYATNARYTPRKVSSGSVLRKISSFFRKD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
359PhosphorylationLFTKASISTTSLVKS
CCCCCEEECHHHHHC		24.1229996109
360PhosphorylationFTKASISTTSLVKSN
CCCCEEECHHHHHCC		20.8021712547
361PhosphorylationTKASISTTSLVKSNV
CCCEEECHHHHHCCC		17.1724763107
362PhosphorylationKASISTTSLVKSNVS
CCEEECHHHHHCCCC		31.1124763107
375PhosphorylationVSTNSRKSSNFEDEL
CCCCCCCCCCHHHHH		29.4229996109
376PhosphorylationSTNSRKSSNFEDELA
CCCCCCCCCHHHHHH		48.8825720772
388PhosphorylationELARRVSSPLSALNQ
HHHHHHHCHHHHHHH		27.3125720772
397PhosphorylationLSALNQMSQSPIPIR
HHHHHHHCCCCCCEE		20.1025720772
548PhosphorylationPNITNVRSASAPLCS
CCCCCCCCCCCCCCC		23.4625720772
550PhosphorylationITNVRSASAPLCSSP
CCCCCCCCCCCCCCC		31.5028889911
555PhosphorylationSASAPLCSSPVPSRR
CCCCCCCCCCCCCCC		45.4129996109
556PhosphorylationASAPLCSSPVPSRRY
CCCCCCCCCCCCCCH		28.9929996109
560PhosphorylationLCSSPVPSRRYSQYA
CCCCCCCCCCHHHCC		29.6225720772
564PhosphorylationPVPSRRYSQYATNAR
CCCCCCHHHCCCCCC		18.2029996109
566PhosphorylationPSRRYSQYATNARYT
CCCCHHHCCCCCCCC		14.9529996109
578PhosphorylationRYTPRKVSSGSVLRK
CCCCCCCCHHHHHHH		31.8325720772
579PhosphorylationYTPRKVSSGSVLRKI
CCCCCCCHHHHHHHH		37.7725720772
587PhosphorylationGSVLRKISSFFRKD-
HHHHHHHHHHHCCC-		24.9125720772
588PhosphorylationSVLRKISSFFRKD--
HHHHHHHHHHCCC--		31.7025720772
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CDR1_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CDR1_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CDR1_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
WEE1_SCHPOwee1genetic
16816416
RAD24_SCHPOrad24genetic
16816416
CDK1_SCHPOcdc2genetic
2004705
CG23_SCHPOcdc13genetic
2004705
MPIP_SCHPOcdc25genetic
2004705
WEE1_SCHPOwee1genetic
2245912
CDK1_SCHPOcdc2genetic
2245912
NIF1_SCHPOnif1physical
9135149
WEE1_SCHPOwee1physical
9928955
MSP1_SCHPOmsp1physical
9928955
WEE1_SCHPOwee1physical
8515818
WEE1_SCHPOwee1physical
8515817
CDR1_SCHPOcdr1physical
7681363
CHK1_SCHPOchk1genetic
16816416
CDR1_SCHPOcdr1physical
16816416
MEX67_SCHPOmex67genetic
22681890
VIP1_SCHPOasp1genetic
22681890
BST1_SCHPObst1genetic
22681890
ULP2_SCHPOulp2genetic
22681890
YE08_SCHPOSPAC17H9.08genetic
22681890
RM39_SCHPOmrpl39genetic
22681890
YOW5_SCHPOSPBC1861.05genetic
22681890
SAT1_SCHPOsat1genetic
22681890
SHF1_SCHPOshf1genetic
22681890
YOX1_SCHPOyox1genetic
22681890
CUT12_SCHPOcut12genetic
2245912
PP2A2_SCHPOppa2genetic
22624651
SOL1_SCHPOsol1genetic
22624651
SNF5_SCHPOsnf5genetic
22624651
ZFS1_SCHPOzfs1genetic
22624651
FLP1_SCHPOclp1genetic
22624651
NIF1_SCHPOnif1genetic
22624651
SKI3_SCHPOSPCC1919.05genetic
22624651
NUDC_SCHPOSPBC19F8.02genetic
22624651
PAB2_SCHPOpab2genetic
22624651
GBB_SCHPOgit5genetic
22624651
GIT3_SCHPOgit3genetic
22624651
KAPB_SCHPOpka1genetic
22624651
OLA1_SCHPOSPAC27E2.03cgenetic
22624651
GPA2_SCHPOgpa2genetic
22624651
PYP1_SCHPOpyp1genetic
22624651
SGF73_SCHPOsgf73genetic
22624651
SKB1_SCHPOskb1genetic
23615447
HOG1_SCHPOsty1genetic
22624651
MOB2_SCHPOmob2physical
23615447
NIF1_SCHPOnif1physical
23615447
SKB1_SCHPOskb1physical
23615447
WEE1_SCHPOwee1physical
23615447
CDR2_SCHPOcdr2physical
26071525
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CDR1_SCHPO

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-550, AND MASSSPECTROMETRY.

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