RAD24_SCHPO - dbPTM
RAD24_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RAD24_SCHPO
UniProt AC P42656
Protein Name DNA damage checkpoint protein rad24
Gene Name rad24
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 270
Subcellular Localization
Protein Description Required for the DNA damage checkpoint that ensures that DNA damage is repaired before mitosis is attempted. Acts as a negative regulator of meiosis by antagonizing the function of mei2. It inhibits the association of meiRNA (a non-coding RNA molecule required for the nuclear mei2 dot formation) to the phosphorylated but not to the unphosphorylated form of mei2 in vitro..
Protein Sequence MSTTSREDAVYLAKLAEQAERYEGMVENMKSVASTDQELTVEERNLLSVAYKNVIGARRASWRIVSSIEQKEESKGNTAQVELIKEYRQKIEQELDTICQDILTVLEKHLIPNAASAESKVFYYKMKGDYYRYLAEFAVGEKRQHSADQSLEGYKAASEIATAELAPTHPIRLGLALNFSVFYYEILNSPDRACYLAKQAFDEAISELDSLSEESYKDSTLIMQLLRDNLTLWTSDAEYSAAAAGGNTEGAQENAPSNAPEGEAEPKADA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSTTSREDA
------CCCCCHHHH		40.1521712547
3Phosphorylation-----MSTTSREDAV
-----CCCCCHHHHH		27.7324763107
4Phosphorylation----MSTTSREDAVY
----CCCCCHHHHHH		20.6229996109
5Phosphorylation---MSTTSREDAVYL
---CCCCCHHHHHHH		33.4929996109
31PhosphorylationGMVENMKSVASTDQE
HHHHHHHHHHCCCCC		16.4925720772
34PhosphorylationENMKSVASTDQELTV
HHHHHHHCCCCCCCH		30.2928889911
48PhosphorylationVEERNLLSVAYKNVI
HHHHHHHHHHHHHHH		14.1025720772
51PhosphorylationRNLLSVAYKNVIGAR
HHHHHHHHHHHHCHH		10.8425720772
66PhosphorylationRASWRIVSSIEQKEE
HHHHHHHHHHHHHHH		24.1928889911
206PhosphorylationQAFDEAISELDSLSE
HHHHHHHHHHHHCCH		38.8721712547
212PhosphorylationISELDSLSEESYKDS
HHHHHHCCHHHHCHH		43.1824763107
234PhosphorylationRDNLTLWTSDAEYSA
HCCCEEECCCHHHHH		21.6027738172
239PhosphorylationLWTSDAEYSAAAAGG
EECCCHHHHHHHCCC		12.8227738172
240PhosphorylationWTSDAEYSAAAAGGN
ECCCHHHHHHHCCCC		11.7027738172
257PhosphorylationGAQENAPSNAPEGEA
CHHHCCCCCCCCCCC		43.1227738172
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RAD24_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RAD24_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RAD24_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MEI2_SCHPOmei2genetic
10788621
MEI2_SCHPOmei2genetic
11818066
RAD13_SCHPOrad13genetic
9613582
STE11_SCHPOste11physical
11702950
FLP1_SCHPOclp1physical
16085489
CHK1_SCHPOchk1physical
12415000
CHK1_SCHPOchk1physical
10090724
MPIP_SCHPOcdc25physical
10090724
MEI2_SCHPOmei2physical
11818066
CHK1_SCHPOchk1physical
15585577
AGO1_SCHPOago1physical
17043360
FLP1_SCHPOclp1genetic
18385517
IF4G_SCHPOtif471physical
20231270
EIF3A_SCHPOtif32physical
20231270
CDC15_SCHPOcdc15physical
20231270
RPN1_SCHPOmts4physical
20231270
RIR1_SCHPOcdc22physical
20231270
EIF3B_SCHPOSPAC25G10.08physical
20231270
MPIP_SCHPOcdc25physical
20231270
HSP71_SCHPOssa1physical
20231270
HSP72_SCHPOssa2physical
20231270
PRS4_SCHPOrpt2physical
20231270
RPN6_SCHPOrpn6physical
20231270
RAE1_SCHPOrae1physical
20231270
RAD24_SCHPOrad24physical
20231270
RAD25_SCHPOrad25physical
20231270
SEM1_SCHPOrpn15physical
20231270
RST2_SCHPOrst2genetic
22496451
PRZ1_SCHPOprz1genetic
22496451
PRZ1_SCHPOprz1physical
22496451
HSP9_SCHPOhsp9genetic
22182414
MPIP_SCHPOcdc25physical
22182414
STE11_SCHPOste11genetic
11702950
FLP1_SCHPOclp1physical
22918952
EIF2A_SCHPOSPBC4B4.04genetic
22681890
UAF30_SCHPOspp27genetic
22681890
RAD57_SCHPOrad57genetic
22681890
EMC1_SCHPOemc1genetic
22681890
RAD24_SCHPOrad24physical
12242289
BYR2_SCHPObyr2physical
12242289
SOG2_SCHPOsog2physical
23394829
NAK1_SCHPOnak1physical
23394829
YF75_SCHPOspa2physical
23394829
FLP1_SCHPOclp1physical
23394829
RGF1_SCHPOrgf1physical
23394829
ASE1_SCHPOase1physical
23394829
YDR8_SCHPOSPAC16E8.08physical
23394829
PPK25_SCHPOppk25physical
23394829
MPH1L_SCHPOmph1physical
23394829
IPYR_SCHPOipp1physical
23394829
SCW1_SCHPOscw1physical
23394829
CDC11_SCHPOcdc11physical
23394829
MUG72_SCHPOmug72physical
23394829
YOG2_SCHPOgsf1genetic
23311928
RGF1_SCHPOrgf1physical
24478458
SSP1_SCHPOssp1genetic
24451546
SSP1_SCHPOssp1physical
24451546
RAD24_SCHPOrad24physical
26771498
GEF1_SCHPOgef1physical
26246599
GEF1_SCHPOgef1genetic
26246599
CDR2_SCHPOcdr2physical
28162898
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RAD24_SCHPO

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-34 AND SER-66, AND MASSSPECTROMETRY.

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