UniProt ID | RGF1_SCHPO | |
---|---|---|
UniProt AC | Q9Y7U6 | |
Protein Name | Rho1 guanine nucleotide exchange factor 1 | |
Gene Name | rgf1 | |
Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). | |
Sequence Length | 1334 | |
Subcellular Localization | Cytoplasm . Septum. Localizes to cell tips during interphase and the septum in mitotic cells. | |
Protein Description | Stimulates the exchange of Rho1 and Rho5 GDP-bound form into GTP-bound form. Controls septum formation, cell wall synthesis and localization of F-actin patches. Coordinates actin deposition with cell wall biosynthesis during bipolar growth.. | |
Protein Sequence | MDYRHPNALGVNESSRAYEEIFGAPRKREPARTVSTPAFMEPAPVSKKPLPPPTRRLPRKPLPFRSTSLQPPSSQPPAPPTHQREASPVKNIEHSESFPSVFGTSNNHQIVPLTLKDGNDFGALYASLNTTPHFPQVSNHAPNNSNSPSLTWHTSSGDDSNQNPFFVRRQSQSSTSPVSDSVDENLLSAVSSVTESVETNLHLDQNYPYGSPVRSSKNPFLSSNSRLPTDDSSHTVGSHSFTSGTHPPIVSSNSAFTLPNAVTPAAQAPLIRSVSEYPANVSPPAQSLQLPKSTSNPADLHLSIASASSHKNIFSGLDVFSNVFHGPSTTLRDREHDMRNRSFDHSTLAHYEAVKQQRLGVEPTARSFTLSSYKSRASGNSLINDRSSTTTPTFVNSEASSPVHKNKRRRRIYAALLSRVASELLDRLQLGDITKDGLIYSNAFTGDHAVTVLMGIIHTSDRNLALLVGRSLDAQKFIHDVTYDHRLRDSHREIYQLQGTGYRPFLRANDNASINNKNHHKELEDNESGTRISPSTLGDTSFPNGIFTLLTHCYSPTCAKDHPCYSISCPRRLEQQHRLFAKMRANTEQSSSLAFDDKEQKLWIHSVPQEIAYSVSDRERKRQEVICEVIYTERDFVKDLEYLRDYWIKPLWASSCIPERKKEKFIRTVFLNALEVQAVNSKLAEALTKRQNYKPIVDNIADIFLEHVPKFEPFIRYGAGQLYGKYEFEKEKSSNPAFAKFVSDVERLKESRKLELNGYLTKPTTRLARYPLLLEAVLKYTDEGNPDKQDIPKVINIVRGFLSRLNVESGKAENKFNLFHLNQQLVFKPGEHYDLHLLDANRQLIFKGPLKKRSAGSTSSESASDVTLFLFDHALLIVKPKTINKRELLKVFQRPIPLLLLQLFLVDDNGLRIPYSSKQQLAAVSKAANGKPPSRFYPFSLQLLGRRGYEITLYATTEVSRDKWLEHIDNQQTLLQHRNQWFESVTICSNFFVGDNKVNAIGVYDSGRRLLYGTDTGVYVSLRKANSPLQFKPVRALNIPNISQLEVIEEYSLLLLLSDKVLYSYPLEMIDADTTQAPKKARKVSGHTTFFRVGICLGKVLVCAVKSSVLSATIKVFEPVTNYSKTRNMPSLKKFLTVNQDPLRIVKELYIPTESTSVHFLKNKLCVGCTRGFEVVSLDNLETQSLLDPADTSLEFVEKKENVKPIAIYRMNGGEFLLCYSQFAFYVNRDGWRSRPTWFVVWEGSPQNFALSYPYILAFEPTFIEIRHVETSELIHVISGRNIRLLADGRGKLGDGGEIFYACDQRGENCETSVVCSLRLTSAAAHAKEQHVDK | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
35 | Phosphorylation | REPARTVSTPAFMEP CCCCCEECCCCCCCC | 28.23 | 29996109 | |
68 | Phosphorylation | PLPFRSTSLQPPSSQ CCCCCCCCCCCCCCC | 26.67 | 29996109 | |
87 | Phosphorylation | PTHQREASPVKNIEH CCCCCCCCCCCCCCC | 26.02 | 29996109 | |
95 | Phosphorylation | PVKNIEHSESFPSVF CCCCCCCCCCCCCCC | 23.34 | 29996109 | |
222 | Phosphorylation | SSKNPFLSSNSRLPT CCCCCCCCCCCCCCC | 28.05 | 29996109 | |
223 | Phosphorylation | SKNPFLSSNSRLPTD CCCCCCCCCCCCCCC | 40.76 | 29996109 | |
225 | Phosphorylation | NPFLSSNSRLPTDDS CCCCCCCCCCCCCCC | 36.82 | 29996109 | |
282 | Phosphorylation | SEYPANVSPPAQSLQ HHCCCCCCCCHHHCC | 25.60 | 29996109 | |
287 | Phosphorylation | NVSPPAQSLQLPKST CCCCCHHHCCCCCCC | 21.86 | 29996109 | |
342 | Phosphorylation | EHDMRNRSFDHSTLA HHHHHCCCCCHHHHH | 38.28 | 25720772 | |
346 | Phosphorylation | RNRSFDHSTLAHYEA HCCCCCHHHHHHHHH | 27.28 | 28889911 | |
347 | Phosphorylation | NRSFDHSTLAHYEAV CCCCCHHHHHHHHHH | 25.25 | 29996109 | |
364 | Phosphorylation | QRLGVEPTARSFTLS HCCCCCCCCCCEEHH | 22.61 | 25720772 | |
367 | Phosphorylation | GVEPTARSFTLSSYK CCCCCCCCEEHHHHC | 21.81 | 21712547 | |
369 | Phosphorylation | EPTARSFTLSSYKSR CCCCCCEEHHHHCCC | 27.29 | 24763107 | |
371 | Phosphorylation | TARSFTLSSYKSRAS CCCCEEHHHHCCCCC | 28.67 | 21712547 | |
372 | Phosphorylation | ARSFTLSSYKSRASG CCCEEHHHHCCCCCC | 39.43 | 21712547 | |
373 | Phosphorylation | RSFTLSSYKSRASGN CCEEHHHHCCCCCCC | 15.03 | 25720772 | |
375 | Phosphorylation | FTLSSYKSRASGNSL EEHHHHCCCCCCCCC | 25.50 | 25720772 | |
378 | Phosphorylation | SSYKSRASGNSLIND HHHCCCCCCCCCCCC | 37.08 | 25720772 | |
381 | Phosphorylation | KSRASGNSLINDRSS CCCCCCCCCCCCCCC | 33.87 | 28889911 | |
387 | Phosphorylation | NSLINDRSSTTTPTF CCCCCCCCCCCCCEE | 34.59 | 25720772 | |
388 | Phosphorylation | SLINDRSSTTTPTFV CCCCCCCCCCCCEEC | 30.57 | 29996109 | |
389 | Phosphorylation | LINDRSSTTTPTFVN CCCCCCCCCCCEECC | 35.62 | 29996109 | |
390 | Phosphorylation | INDRSSTTTPTFVNS CCCCCCCCCCEECCC | 32.50 | 25720772 | |
391 | Phosphorylation | NDRSSTTTPTFVNSE CCCCCCCCCEECCCC | 22.03 | 29996109 | |
393 | Phosphorylation | RSSTTTPTFVNSEAS CCCCCCCEECCCCCC | 37.82 | 29996109 | |
397 | Phosphorylation | TTPTFVNSEASSPVH CCCEECCCCCCCCCC | 29.27 | 29996109 | |
400 | Phosphorylation | TFVNSEASSPVHKNK EECCCCCCCCCCCCH | 30.99 | 29996109 | |
401 | Phosphorylation | FVNSEASSPVHKNKR ECCCCCCCCCCCCHH | 37.68 | 29996109 | |
513 | Phosphorylation | LRANDNASINNKNHH CCCCCCCCCCCCCCC | 31.91 | 29996109 | |
528 | Phosphorylation | KELEDNESGTRISPS CCCCCCCCCCCCCHH | 52.28 | 29996109 | |
533 | Phosphorylation | NESGTRISPSTLGDT CCCCCCCCHHHCCCC | 14.98 | 27738172 | |
717 | Phosphorylation | KFEPFIRYGAGQLYG CCCHHHCCCHHHEEE | 13.40 | 25720772 | |
723 | Phosphorylation | RYGAGQLYGKYEFEK CCCHHHEEECEECCC | 12.04 | 25720772 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RGF1_SCHPO !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RGF1_SCHPO !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RGF1_SCHPO !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
ITS3_SCHPO | its3 | physical | 15923187 | |
RHO1_SCHPO | rho1 | genetic | 16421249 | |
BGS4_SCHPO | bgs4 | genetic | 16421249 | |
PCK1_SCHPO | pck1 | genetic | 16421249 | |
RGF2_SCHPO | rgf2 | genetic | 16324155 | |
RGF3_SCHPO | rgf3 | genetic | 16324155 | |
RAD24_SCHPO | rad24 | physical | 24478458 | |
DNLI4_SCHPO | lig4 | genetic | 28334931 | |
RFA1_SCHPO | ssb1 | genetic | 28334931 | |
RAD22_SCHPO | rad52 | genetic | 28334931 | |
RAD54_SCHPO | rad54 | genetic | 28334931 |
Kegg Drug | ||||||
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DrugBank | ||||||
There are no disease associations of PTM sites. |
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