RGF3_SCHPO - dbPTM
RGF3_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RGF3_SCHPO
UniProt AC Q9Y7U5
Protein Name Rho1 guanine nucleotide exchange factor 3
Gene Name rgf3
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 1275
Subcellular Localization Cell septum . Localizes to the outer area (150 nm) of the contractile ring.
Protein Description Stimulates the exchange of Rho1 GDP-bound form into GTP-bound form. Regulates, via interaction and activation of Rho1, beta-1,3-glucan biosynthesis and cell wall integrity during septation. Involved in the regulation of contractile ring assembly..
Protein Sequence MKLSNELFHRSSKDHGGKSRICLDSSEDTYPPHSSSPPSFQKRLSFSDFSTTRLFSPPFLSKRSNNSPHRFSYSPPQHPASINSRRVASYTVQSSPSRTTYRQLPNEPQNSAAYTTYSSFPNALFDDFSPNNPLDTDPFLTSPGNKQNTVDSFRPLPETPVSPGGSLVHPLPRPPLPSSVSSHSSPYSTTSSTSLYSLYNDISLSCSPEPYLPLSPTRSPARTPSPIRLYSSDALRPQSPLSPSVEYLTPPNPYSLKSDISSTRQLPKIPVQDYASGKISSPLITRTHRRAQSETLFSSCREPWLVGKLYKWCKEEVFTALGGLVHEGVSRREVAQVMATLFTIHIASMEFLIAEIIAKNILGDWINYGLVEVINLEKLQIAFTSNEPPSGSGVLPFLTNGGCYSYICRSRSCPSKYQCYSCRCARNSSLEFTSLPGQSSDTWSIFWNISSLNSLPSSLSKREIARQNNIHELICKESDYVADLNTLAELFRDGIVQQQDAIVPSNRVADFIQSVFGNVESIRQLHSRLFLPQLIMRERLQGPVVSIIGDILLEWIHAAKSSYINYAKQFPLADETYKLECQRNTYFARWLAACRSDPRCRRLDFQHFLQRPTQRLQRYTLELDTILKHTEQSSWDFQLITQAVKELRATCEECDAVIATVLEANRIRDLSYQLLFKNHESVNLELRDPEREFFFEGIVQRRSDSRLDWLDIHLFLLDNYLIMAKARKDKRTNASRYVVSKRPIPLDLLVLSPKMDDFQLKSNTNKFLGSLAGNLPQESLTTKSKRKSKVNLELMFDATAEKNNENSMNSAVFEKSQLYPFTIRHLGAYTASYTLYVESLQLRKLWVEKINVAKKRHSQKINIKNPFALKVVSDVAFQYPPSDLVNGNEPLNSFNEITLVEGSSIDRALNEVAWKHPIVSEELLPEPIAYGDISCIAQFNDYEGHVSVLIATSTGIFLGAFGDSSDIRDWKKISSQRRVTQLGVVEEFDILLELRDKTLYAHKLSRIIEMGLIESKIAVVIGTPHAVSFFKIGKLSEGASVKRERTLVFYKEGLGNTTTIICCEPVIGLGHNYQKTYAFKRKDVTSFRTLDDFHVTANCHSIDCFKYSIALCHNKGIDVLRLDPKLAVGFPSPSVLNDTLFRNRINNSKPLGVFRIHDPSLFACCYQFGAVFVNGEGSMVNKECWFDWIGKPNSVTSCHGYLIAFNDEFVEIWNTRTRKLNQIIQGNDIKYYPSNSDWLANGKYIMFGMVHPQYHDRHLILALNKAKTNSFIIED
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
34PhosphorylationEDTYPPHSSSPPSFQ
CCCCCCCCCCCCCHH		37.9829996109
36PhosphorylationTYPPHSSSPPSFQKR
CCCCCCCCCCCHHHC		43.7927738172
39PhosphorylationPHSSSPPSFQKRLSF
CCCCCCCCHHHCCCC		43.6327738172
45PhosphorylationPSFQKRLSFSDFSTT
CCHHHCCCCCCCCCC		27.0821712547
56PhosphorylationFSTTRLFSPPFLSKR
CCCCCCCCCCCCCCC		35.9321712547
72PhosphorylationNNSPHRFSYSPPQHP
CCCCCCCCCCCCCCC		25.3429996109
74PhosphorylationSPHRFSYSPPQHPAS
CCCCCCCCCCCCCCC		28.9829996109
89PhosphorylationINSRRVASYTVQSSP
CCCCCEEEEEECCCC		20.6229996109
90PhosphorylationNSRRVASYTVQSSPS
CCCCEEEEEECCCCC		10.9525720772
91PhosphorylationSRRVASYTVQSSPSR
CCCEEEEEECCCCCC		15.0125720772
94PhosphorylationVASYTVQSSPSRTTY
EEEEEECCCCCCCCC		39.6229996109
95PhosphorylationASYTVQSSPSRTTYR
EEEEECCCCCCCCCC		15.1429996109
97PhosphorylationYTVQSSPSRTTYRQL
EEECCCCCCCCCCCC		44.1825720772
223PhosphorylationPTRSPARTPSPIRLY
CCCCCCCCCCCEEEE		30.1725720772
225PhosphorylationRSPARTPSPIRLYSS
CCCCCCCCCEEEECC		32.1425720772
239PhosphorylationSDALRPQSPLSPSVE
CCCCCCCCCCCCCCE		30.4125720772
242PhosphorylationLRPQSPLSPSVEYLT
CCCCCCCCCCCEECC		20.6525720772
280PhosphorylationDYASGKISSPLITRT
HCCCCCCCCCCCCCH		29.4129996109
281PhosphorylationYASGKISSPLITRTH
CCCCCCCCCCCCCHH		27.4828889911
293PhosphorylationRTHRRAQSETLFSSC
CHHHHHCHHHHHHHC		31.4028889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RGF3_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RGF3_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RGF3_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
GYP10_SCHPOgyp10genetic
16291723
RHO1_SCHPOrho1genetic
15546915
YOCC_SCHPOpxl1genetic
18256290
RHO4_SCHPOrho4physical
20199606
WSC1_SCHPOwsc1genetic
20739711
RGF1_SCHPOrgf1genetic
20739711
RHO1_SCHPOrho1genetic
20739711
SPN3_SCHPOspn3genetic
16291723
RHO1_SCHPOrho1genetic
16291723
RHO1_SCHPOrho1genetic
16324155
RGF2_SCHPOrgf2genetic
16324155
RGF1_SCHPOrgf1genetic
16324155
GEF3_SCHPOgef3genetic
24947517
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RGF3_SCHPO

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-293, AND MASSSPECTROMETRY.

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