GEF3_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GEF3_SCHPO
• UniProt AC: O59679
• Protein Name: Rho guanine nucleotide exchange factor gef3
• Gene Name: gef3
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 525
• Subcellular Localization: Cytoplasm . Septum.
• Protein Description: Has a role in the control of cell polarity and cytokinesis. Involved in bipolar growth and septum formation..
• Protein Sequence: MSNPRMFQSRGKRVVSDSLPIANSTHTLEDTLKLRPDWTIALSQHETETRSTRTSCSTTTESTIAMRSKQKAIISVLEEFRDSEAAYVHDLHVAQRYYADRLSDRVKKSEWKDVFEIFLVLCKQASLFEIEMHKSLNDEINYILDDQDACLKPKPSVAQLFLSWLPKLSAVYGRYCVIQENIGKKVEKWMKNSSISEYLQECDSMAKIESNSWNLDSFLVKPVQRFLKYPLLLNQLYRSASLGIISDYVLLGEACHKSEIASQRMNELKRRRDIIITALDSVSNSQEVLLLSTDSIDKKIAKLQNSTNIFYVPEHEPILAFVHQLSSSYTNLLNLRSAICDWLKFSRYHYLKFFTFVEAYSVFCKDTKSADKWALISVALDNIAKGAVLRLTEQCQTSVLRPISNGILFFRNPLCVTDVWIKKATAFSKRRQSQVFEEDLESFPLLSNCLLEELPLFLEMARNVTDECILAFAQIQATFYDTIQKVLEPVVAKFNLTDHQDIPSIESIMDFTSLRSSMESSPKSK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Phosphorylation	SRGKRVVSDSLPIAN CCCCEEECCCCCCCC	20.73	21712547
512	Phosphorylation	IESIMDFTSLRSSME HHHHHHHHHHHHHHH	23.69	21712547
513	Phosphorylation	ESIMDFTSLRSSMES HHHHHHHHHHHHHHC	23.06	21712547
520	Phosphorylation	SLRSSMESSPKSK-- HHHHHHHCCCCCC--	43.21	21712547

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GEF3_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GEF3_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GEF3_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RHO3_SCHPO	rho3	genetic	24947517
CDC42_SCHPO	cdc42	genetic	24947517
SEC8_SCHPO	sec8	genetic	24947517
AP1M1_SCHPO	apm1	genetic	24947517
FOR3_SCHPO	for3	genetic	24947517

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.