SEC8_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SEC8_SCHPO
• UniProt AC: O74562
• Protein Name: Exocyst complex component sec8
• Gene Name: sec8
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 1073
• Subcellular Localization: Cytoplasm . Cell tip . Cell septum . Cytoplasmic vesicle . Associated with the actinomyosin ring at the division site and at the cell tips.
• Protein Description: Component of the exocyst complex involved in the delivery of secretory vesicles to the plasma membrane. Also required for polarized cell growth and division septum assembly. The exocyst complex plays an important role in the targeting of rho3, as well as the two main hydrolases required for cell separation, eng1 and agn1, to the cell wall surrounding the septum before cell separation begins..
• Protein Sequence: MDTRGYSETKKGRYPVGKKSLESPNGYSNYGTSMDNELSSEYASRGMHIGDLENLVNEIEDEWKDLGREDYQPISTALELLDDSSFGRDYKSFLNVYDRISAALQTIAHTHKDDFTRGISAYGEIMEGIQKCNSRIIALKQSLEASQECIGNTNSKELQQTLARSSQYKKVISVLKELNEANQLFDNFHTLVDSKQYYHASDLIRRVWDELSRSDFDGILVVEQFKSRMTGLLSHLEDILSEELVSITFLKDAVAYPIVSYCSPNPLRETSNPYFLRDFLKNNANTSTLGQSEQLRYLEEALSLKLSDCLKMDYGRDSLRDIRIVLESLNLLGKLPNAISSLKSRTSAEMFTTVDSTSRAIVNKYSLGNNVSTVNPFSKSLYDIGLHAETDREHTMISEFLTNLFTKLRCVLMHYRGISEFMTKLETKTPKHASSSHKSSIMSVNSDPTSPKVSKFDTSDSTFPFDTLLQAFESEIRLMLKDYLISKEEYIENSGNFVVGTEMSIYNLPGENEEDKLFDVTNEIAVENKSNAFYARINELVNEKAPELILNKSNASVSTIELFSGSSKEIVRLAGHVVFVGPSVFHASSVLPQTVFFLEDSVSILKNPNIPPQFAVNFMKEFLRGSYIPQLYKFMSSHFDTIMKDVGAFQLHRDWKIYSKIPIFKCHVAIVQYFHDLQDYLPIVALNLVEFYELLHTLLVRFRNHCSDYLSDLCRTAVLKEYKHVNEDTEDVDDTVRVKLLHDDVTYPQFIKFLKQKNPSLEGLNELCRMENKRLLQYEDRAITSEVKLPVSVLSKDSDLVNSVSYLHNSMEWFLQRCFSRFMNGSRRMNVLQQNQANFGGDFLPIDNLLGNNSDLMKGAYKEVFDSLQRLQFDALLLIRMEVRLQYIHSINQSVNLPDYVVEYRGRPDASIMALNSTIVTTNLKLETCLNEWERRFVFQGLSELVDSSLYSIFYKIESMNRGSCLQMLKNMSAMIQILKTVKEIHGDVEFPKSSRVFGIYQNGAKKIIEHFIAAPKKELLPDVKQMVRIYYQRLMKDAKRNGRDDLYRQYQKKIGSVLTQFDNTVGGARKNP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
20	Phosphorylation	RYPVGKKSLESPNGY CCCCCCCCCCCCCCC	40.63	25720772
443	Phosphorylation	SHKSSIMSVNSDPTS CCCCCCEECCCCCCC	19.24	29996109
446	Phosphorylation	SSIMSVNSDPTSPKV CCCEECCCCCCCCCC	42.69	24763107
449	Phosphorylation	MSVNSDPTSPKVSKF EECCCCCCCCCCCCC	63.75	28889911
450	Phosphorylation	SVNSDPTSPKVSKFD ECCCCCCCCCCCCCC	28.28	28889911
760	Phosphorylation	FLKQKNPSLEGLNEL HHHHHCCCCHHHHHH	48.74	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SEC8_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SEC8_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SEC8_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SEC6_SCHPO	sec6	physical	11854409
SEC10_SCHPO	sec10	physical	11854409
EXO70_SCHPO	exo70	physical	11854409
CDC42_SCHPO	cdc42	genetic	21899677
YD6C_SCHPO	sec3	physical	22891673
RHO3_SCHPO	rho3	genetic	21652630
EXO70_SCHPO	exo70	genetic	21652630
FOR3_SCHPO	for3	genetic	21652630
MYO52_SCHPO	myo52	genetic	21652630
FOR3_SCHPO	for3	genetic	21401840
RHO4_SCHPO	rho4	genetic	25724972

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-449 AND SER-450, ANDMASS SPECTROMETRY.
PubMed: 18257517