dbPTM

EXO70_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	EXO70_SCHPO
UniProt AC	Q10339
Protein Name	Exocyst complex component exo70
Gene Name	exo70
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	615
Subcellular Localization
Protein Description	Required for exocytosis..
Protein Sequence	MSGGIFDDNKAGFETFQKNLNSVAKNVSDASNILLSMDKRLSGLEASAGILRDDVTNYNRVSSNIYDTLKEMESLQVIHSHLPVLQKGLQECQNLNKSVSQNLKSVMDILKSLAEDYTSLEGSPLQFASKSQQKVEMMLSEGCQILGALCYNILETYAASSLNKASTLLDLSIPWSFPNESLQQFIGLIQQFDADVLFPVSCSSDISNIYIKIKGECVVKLLHAVSMRTDEIKLNEGSVNFVTGKEDVSINLVALSRLLPAVASELLLLFDQVTAKALYPKIVKPAINTVTNATRQLEGVYEKRGAAENFVLLSLIDCIVVTRQNMNNLMPFEDASFLGFVNGVGREMEKILISSISRLYNGTCHNNKTVPLTTDRVSEMTHGIMSFLNELAEHENASYLLESIGNWGWRHEINADLSPARSVQDITRNYVMDCMDSYLTSVQTAAQAVDTIGWKMGVMLLNISVYFEAKCLESKIASFLQDVDLEKLGDRSQKYSTMYMEVWRQCSQNMLDSTYTKSQNKSTMSAKEREITKEKFRNFNEQVTSVVQVHRESVRFETGVATFLLQEVKKTVLPLYQRFYDKYINSDFTKNKDKYIKFTKADLDSFITSAFAPSL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSGGIFDDN ------CCCCCCCCC	45.81	28889911
42	Phosphorylation	LSMDKRLSGLEASAG HHHHHHHCCCHHHHC	45.42	29996109
418	Phosphorylation	HEINADLSPARSVQD CCCCCCCCCCCCHHH	19.63	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of EXO70_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of EXO70_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of EXO70_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RHO3_SCHPO	rho3	genetic	12930742
GYP10_SCHPO	gyp10	genetic	16291723
CDC42_SCHPO	cdc42	physical	21899677
FOR3_SCHPO	for3	genetic	21652630

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of EXO70_SCHPO

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of fission yeast."; Wilson-Grady J.T., Villen J., Gygi S.P.; J. Proteome Res. 7:1088-1097(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2 AND SER-418, AND MASSSPECTROMETRY.	18257517 [Abstract]