RGF2_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RGF2_SCHPO
• UniProt AC: Q9UTR5
• Protein Name: Rho1 guanine nucleotide exchange factor 2
• Gene Name: rgf2
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 1158
• Subcellular Localization: Cytoplasm . Septum. Localizes to cell tips during interphase and the septum in mitotic cells.
• Protein Description: Stimulates the exchange of Rho1 and Rho5 GDP-bound form into GTP-bound form. Controls septum formation, cell wall synthesis and localization of F-actin patches..
• Protein Sequence: MLRNGAQNGNINSESHESFGKAAKGFRIFSSFSSSQKLFQRRSSGSITHSPTALSSTTSLNENDGNHFRPASSLSFSPSSLSRKDSGPGDGLEVNKKNNFYRRSSSTDDFGISHARSRKEIQSLGRPHTRQSFSVSDVSNGSSYPNIRKNSVHVNAPMPSFPEGSTAVLLKHHSGSKSASAISNIAPSHSNSTSSRRPYIHPAFLSQVAVEFRKRLNIGDRVKDGLLYKDAFLGSEAVDVLMHIVRTTDRNLALLLGRALDSQKMFHDVTYSHRLRDSLKEVYQYRRIISPPPGLSSMDSNGSSIENNFLYTKRRANTSDSFDSVLSDSSTTPTISSSVQVNSLAFITSSLSAITKEPEAPETEYNPHGVFTLLTECYSSTCSRNRLCYSISCPRRLEQQARLHLKVQPVLSGGSTSITDKQEEDHRLWSENVPKQVVDQIDVREWKRQEIIFEVIYTERDFVRDLEYIRDFWIKPLSTSNVIPENNRQQFIRCVFHNIMQIHAVNSRLSNALNRTQTLQPVVNTIGDLFLDYVPKFEPFIKYGANQAIAKFEFEREKSTNRNFANYVHEVERLRESRKLELNGYLTKPTTRLARYPLLLSGVLKYTDKDNPDTENIPRVIEMIREFLTKLNYETGKTENRLSLLQLNEQLSCSPADRAKLTLFDPSRLLIFKGVVKLKASSYSNGDTENDIHMFLLDNFLLLCKIKIQMKRRVHKLHLRPLPLELLSISYIEDSPSRGSLPRRPSSALLTNPISITKSNPPPVKAYGLQLVFIGARGFSISLYLNTLIARDQWKQHIEKQQDIIRKRHLVFESRGICCQSWFTGNKLLCAVAYDAGRKLLFGTYKGLYISSRKSNNGSCLEPIFKLQLPNISQLDVIEEHNVLLLLAEKILYELPLDALDSVEQINSKSLRRVTGHVSFVKTGFCMQRILVCAVKSTVLNTTLRIYEADRALKNKKTQSLKKPFGNQATLKIFTEVQMPMEALSVHFLKTKLCVGSFKGFDIISLENAVFQSLLNPADTSFRFLEKREDIRPIAMFRLRGEFLLCYSDFAFFVNTNGWKSRQSWMINWEGQPQGCALCYPYILAFEPDFIEIRNAETAELVQIIMGQNIKLLTDGRGLISEGGEILYSTEPIPFSSGENPIVHSLILPPANAAGPAL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
34	Phosphorylation	RIFSSFSSSQKLFQR EEEECCCCCHHHHHH	34.47	25720772
86	Phosphorylation	SSLSRKDSGPGDGLE HHHCCCCCCCCCCCE	50.34	25720772
104	Phosphorylation	KNNFYRRSSSTDDFG CCCCCCCCCCCCCCC	21.46	25720772
105	Phosphorylation	NNFYRRSSSTDDFGI CCCCCCCCCCCCCCC	35.13	29996109
106	Phosphorylation	NFYRRSSSTDDFGIS CCCCCCCCCCCCCCC	36.78	29996109
107	Phosphorylation	FYRRSSSTDDFGISH CCCCCCCCCCCCCCC	41.35	25720772
113	Phosphorylation	STDDFGISHARSRKE CCCCCCCCCHHHHHH	16.09	25720772
117	Phosphorylation	FGISHARSRKEIQSL CCCCCHHHHHHHHHC	48.78	28889911
129	Phosphorylation	QSLGRPHTRQSFSVS HHCCCCCCCCCCCHH	32.84	25720772
151	Phosphorylation	YPNIRKNSVHVNAPM CCCCCCCCEEECCCC	19.35	24763107
178	Phosphorylation	KHHSGSKSASAISNI EECCCCCCHHHHCCC	29.20	25720772
180	Phosphorylation	HSGSKSASAISNIAP CCCCCCHHHHCCCCC	32.97	29996109
190	Phosphorylation	SNIAPSHSNSTSSRR CCCCCCCCCCCCCCC	36.49	29996109
746	Phosphorylation	GSLPRRPSSALLTNP CCCCCCCCCCCCCCC	26.82	28889911
747	Phosphorylation	SLPRRPSSALLTNPI CCCCCCCCCCCCCCC	26.14	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RGF2_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RGF2_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RGF2_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
WSC1_SCHPO	wsc1	physical	23907979

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-746 AND SER-747, ANDMASS SPECTROMETRY.
PubMed: 18257517