ITS3_SCHPO - dbPTM
ITS3_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ITS3_SCHPO
UniProt AC O13853
Protein Name Phosphatidylinositol 4-phosphate 5-kinase its3
Gene Name its3
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 742
Subcellular Localization Nucleus. Membrane
Peripheral membrane protein. The active form of the enzyme is membrane-associated and concentrates at the septum in dividing cells.
Protein Description Involved, together with the calcineurin ppb1, in cytokinesis..
Protein Sequence MKIDSNGIVNPHSITNEIPSYDEKQAVDLNGNAFAPNGTFQKKDLISHKNDFERTMRHDVLHTNPKIEVRSETHIYEPNDSLFKENQDFPSNPTAHSPSSSSNDSVITATGVPDGILRDSPIVSALEPPSSNSSSSPQLQNLKHQLSSPQPSRAPIDRSSSNPVTSSQQPPNDRSTLSSSQKAKRPLKRSYSEKNSSNAEPSGSRSGDRGTNVSTSGSLLDGIPPDIGSASWAEAVKQKRVNMRRRREELDDECVLVGTRVSEGHENYVTAYNMLTGIRVGVSRCQAKMDRELTPADFTARHKFTFDITGNELTPSAKYDFKFKDYAPWVFRHLRQLFHLDAADYLVSLTSKYILSELDSPGKSGSFFYFSRDYRFIIKTIHHSEHKFLREILYDYYEHVKNNPNTLISQFYGLHRVKLPFGRKIHFVVMNNLFPPHRDIHQTFDLKGSTLGRELDENQPCQSPMCTMKDTNWIRRNMHLQFGPLKRQIFLTQVKADIDMLSSLGIMDYSLLVGIHDLSRGNRDKIRNSILSVYDPNVSQHRVPSINGNESHSNVHVIRQVVNSTGPVSLDQSCNLLPTDQFVERRNFMFYSDDGGFQATDENNEPGNFIFYIGIIDLLTKYSYVKRVEHLWKGINHSDSVISAVPPAEYASRFYKFVESSIKPTLLVLKPFPLKPQDGQRVNKQQSVNAGNVRTNNKHGSLNNNTAPSSRNAKSTSAHKSPKTEHRFPFPCRNVTTNTSSS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
147PhosphorylationQNLKHQLSSPQPSRA
HHHHHHHCCCCCCCC		33.1425720772
148PhosphorylationNLKHQLSSPQPSRAP
HHHHHHCCCCCCCCC		35.8329996109
159PhosphorylationSRAPIDRSSSNPVTS
CCCCCCCCCCCCCCC		34.0829996109
160PhosphorylationRAPIDRSSSNPVTSS
CCCCCCCCCCCCCCC		34.7229996109
161PhosphorylationAPIDRSSSNPVTSSQ
CCCCCCCCCCCCCCC		46.5325720772
175PhosphorylationQQPPNDRSTLSSSQK
CCCCCCCCCCCHHHH		36.2428889911
176PhosphorylationQPPNDRSTLSSSQKA
CCCCCCCCCCHHHHH		31.3928889911
179PhosphorylationNDRSTLSSSQKAKRP
CCCCCCCHHHHHHCC		39.6425720772
180PhosphorylationDRSTLSSSQKAKRPL
CCCCCCHHHHHHCCC		32.1228889911
190PhosphorylationAKRPLKRSYSEKNSS
HHCCCCCCCCCCCCC		31.2725720772
191PhosphorylationKRPLKRSYSEKNSSN
HCCCCCCCCCCCCCC		25.5325720772
192PhosphorylationRPLKRSYSEKNSSNA
CCCCCCCCCCCCCCC		43.2625720772
196PhosphorylationRSYSEKNSSNAEPSG
CCCCCCCCCCCCCCC		35.7225720772
197PhosphorylationSYSEKNSSNAEPSGS
CCCCCCCCCCCCCCC		49.8325720772
202PhosphorylationNSSNAEPSGSRSGDR
CCCCCCCCCCCCCCC		40.6925720772
204PhosphorylationSNAEPSGSRSGDRGT
CCCCCCCCCCCCCCC		27.8425720772
211PhosphorylationSRSGDRGTNVSTSGS
CCCCCCCCCCCCCCC		33.0827738172
529PhosphorylationNRDKIRNSILSVYDP
CHHHHHHHHHHHCCC		18.3025720772
532PhosphorylationKIRNSILSVYDPNVS
HHHHHHHHHCCCCCC		19.5725720772
545PhosphorylationVSQHRVPSINGNESH
CCCCCCCCCCCCCCC		26.3128889911
551PhosphorylationPSINGNESHSNVHVI
CCCCCCCCCCCEEEE		35.8925720772
638PhosphorylationLWKGINHSDSVISAV
HHCCCCCCCCCHHCC		27.3924763107
640PhosphorylationKGINHSDSVISAVPP
CCCCCCCCCHHCCCH		25.1024763107
643PhosphorylationNHSDSVISAVPPAEY
CCCCCCHHCCCHHHH		22.5129996109
655PhosphorylationAEYASRFYKFVESSI
HHHHHHHHHHHHHCC		11.4721712547
687PhosphorylationQRVNKQQSVNAGNVR
CCCCCCCCCCCCCCC		18.1624763107
701PhosphorylationRTNNKHGSLNNNTAP
CCCCCCCCCCCCCCC		27.8721712547
706PhosphorylationHGSLNNNTAPSSRNA
CCCCCCCCCCCCCCC		41.9121712547
709PhosphorylationLNNNTAPSSRNAKST
CCCCCCCCCCCCCCC		39.1924763107
710PhosphorylationNNNTAPSSRNAKSTS
CCCCCCCCCCCCCCC		28.6121712547
742PhosphorylationVTTNTSSS-------
CCCCCCCC-------		43.9727738172
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ITS3_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ITS3_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ITS3_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PTEN_SCHPOptn1genetic
15249580
PP2B_SCHPOppb1genetic
10950958
PLC1_SCHPOplc1genetic
15923187
BGS1_SCHPObgs1genetic
15923187
PCK2_SCHPOpck2genetic
15923187
SEC8_SCHPOsec8genetic
21148300
FOR3_SCHPOfor3genetic
21148300
DDB1_SCHPOddb1genetic
22681890
YF19_SCHPOatd1genetic
22681890
YE87_SCHPOSPAC9G1.07genetic
22681890
PVH1_SCHPOSPBC17A3.06genetic
22681890
GYP10_SCHPOgyp10genetic
24350606
YPT3_SCHPOypt3genetic
24350606
RYH1_SCHPOryh1genetic
24350606
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ITS3_SCHPO

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Related Literatures of Post-Translational Modification

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