DNLI4_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DNLI4_SCHPO
• UniProt AC: O74833
• Protein Name: DNA ligase 4
• Gene Name: lig4
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 913
• Subcellular Localization: Nucleus.
• Protein Description: Involved in ds DNA break repair..
• Protein Sequence: MDEAKETVFTKPQNHSSTLEFYDFVTTLLEPLSRIGKTRKSKTSNLDPYELKRKILLDYFNKWRQHVGPDLYPLLRLMLPDLDRERGSYGFKEFGLGKLFIRAMHLSPTSEDAKSLKNWRGSESKHTGDFSTMLQDILQRRAYRTFPGAFTVGDVNALLDQLADASSEDTRVNILEQFYRSLSPLELRWLIPILLKVRKYGTSEKFILSVFHPDAARLYRLCSSLKRICWELYDPSRSLDETETDVEVFSCFQPQLANFKKKDLHQTLEAMGNKPFWIEEKLDGERIQLHMSSGKFQFYSRNARSYTYAYGSSYFDEQSRLTQYIIGAFDKRISQIILDGEMVTWDPVLETVIPYGSLRSIFEDSSSHSSYSPYYVVFDILYLNGKSLVKYSLESRRRILEKVIVRESHRMSILPYKVGSTIEDIEAELRNVIQEGSEGLVIKKPSGSYHLGERMDDWIKVKPYYLQGFGEDLDCLILGGYFGRGKQSGKINSFLCGLRMDYTPKDHSEKFQSFVRVGGGFTYFDRDIIRKETEGKWLPWSSDALEYMELAGTKQDFEKPDMWIHPKDSLVLQIKAAEVVVSNRFKTNYTLRFPRLEKVRLDRSWKDALTINEFFTLKNAVEKQDNVSFHVNKKRKVSQKREKQKKFLYDEPTFKKEASPHSDVLKNLHFVVLPPTELHETKAGLQQIIIENGGLIHQGVGNFGKERLFLVADRVSTRVSIERSKNMCTIIRSQWVMDSVNNQRLMPQWSYLLFSKDEKYSWKTALESLSAKSLSNLLVELKQLDLSKEYSKISDDTSILNLTISKEEASFVGAFPFLKFTVFLDLKGIENSELYDVRMGQYRLTKCILLWNGATIEKDISSKKLTHVVMFVEDSTRLEQLTKACELYQIEPKFVNFEWVVNEWKKASTNILG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
305	Phosphorylation	FYSRNARSYTYAYGS EEECCCCCEEEEECC	21.29	25720772
313	Phosphorylation	YTYAYGSSYFDEQSR EEEEECCCCCCCHHH	26.00	25720772
862	Phosphorylation	TIEKDISSKKLTHVV EEEEHHCCCCCEEEE	33.86	21712547

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DNLI4_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DNLI4_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DNLI4_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
H2A1_SCHPO	hta1	genetic	15226425
H2A2_SCHPO	hta2	genetic	15226425
YDHG_SCHPO	SPAC6G9.16c	physical	24847916

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.