H2A1_SCHPO - dbPTM
H2A1_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID H2A1_SCHPO
UniProt AC P04909
Protein Name Histone H2A-alpha
Gene Name hta1
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 132
Subcellular Localization Nucleus. Chromosome.
Protein Description Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling..
Protein Sequence MSGGKSGGKAAVAKSAQSRSAKAGLAFPVGRVHRLLRKGNYAQRVGAGAPVYLAAVLEYLAAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGHVTIAQGGVVPNINAHLLPKTSGRTGKPSQEL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MSGGKSGGK
------CCCCCCCHH		57.14-
5Acetylation---MSGGKSGGKAAV
---CCCCCCCHHHHH		49.8321516229
9AcetylationSGGKSGGKAAVAKSA
CCCCCCHHHHHHHHH		36.3821516229
20PhosphorylationAKSAQSRSAKAGLAF
HHHHHHCHHHHCCCC		39.0925720772
106MethylationLGHVTIAQGGVVPNI
HCCEEECCCCCCCCC		45.3724352239
121PhosphorylationNAHLLPKTSGRTGKP
CEEECCCCCCCCCCC		34.1825720772
122PhosphorylationAHLLPKTSGRTGKPS
EEECCCCCCCCCCCC		32.1929996109
125PhosphorylationLPKTSGRTGKPSQEL
CCCCCCCCCCCCCCC		53.7524763107
129PhosphorylationSGRTGKPSQEL----
CCCCCCCCCCC----		39.5128889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
122SPhosphorylationKinaseBUB1O94751
GPS
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of H2A1_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of H2A1_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
H2A2_SCHPOhta2genetic
15226425
RNA1_SCHPOrna1physical
16540522
RHP9_SCHPOcrb2physical
20679488
CND2_SCHPOcnd2physical
21633354
HRP3_SCHPOhrp3genetic
22681890
TSC2_SCHPOtsc2genetic
22681890
PYP1_SCHPOpyp1genetic
22681890
PROB_SCHPOSPAC17H9.13cgenetic
22681890
YAC5_SCHPOcph1genetic
22681890
PLB2_SCHPOSPAC1A6.03cgenetic
22681890
ARP8_SCHPOarp8genetic
22681890
DAD1_SCHPOdad1genetic
22681890
RAV1_SCHPOrav1genetic
22681890
CSN1_SCHPOcsn1genetic
22681890
YO48_SCHPOSPBC36B7.08cgenetic
22681890
ERS1_SCHPOers1genetic
22681890
RM01_SCHPOSPAC1610.02cgenetic
22681890
ASK1_SCHPOask1genetic
22681890
FFT3_SCHPOfft3genetic
22681890
YA99_SCHPOSPAC13G6.09genetic
22681890
RCD1_SCHPOrcd1genetic
22681890
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of H2A1_SCHPO

loading...

Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Histone H2A phosphorylation controls Crb2 recruitment at DNA breaks,maintains checkpoint arrest, and influences DNA repair in fissionyeast.";
Nakamura T.M., Du L.-L., Redon C., Russell P.;
Mol. Cell. Biol. 24:6215-6230(2004).
Cited for: FUNCTION, MUTAGENESIS OF SER-129, AND PHOSPHORYLATION AT SER-129.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory