TSC2_SCHPO - dbPTM
TSC2_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TSC2_SCHPO
UniProt AC Q9UUG9
Protein Name Tuberous sclerosis 2 protein homolog
Gene Name tsc2
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 1339
Subcellular Localization Cytoplasm . Nucleus .
Protein Description Together with tsc1, required for uptake of various amino acids from the environment and for proper conjugation. Involved in induction of gene expression of permeases and genes required for meiosis upon nitrogen starvation. May act as a GTPase-activating protein (GAP) for the small GTPase rhb1..
Protein Sequence MNNKSLLDLSSEPAIKDTDILSYFDANLPFKKRHQIVRSIYHGLKYYIYSSTSIIQVWQNIQDFISTKNDNAAFRELVYNLMMRYVSTQKHLSIIERHTFFQTIEKDPFQDIAELQLRLKSLSVLTDEGHKISGIENRVGPLLSAWFNQYLQWQSQATELQGKDADSKLVHLLFFKSLFKFSTNLVKFQWFLVPEPQMLQLVNSVVQICNHARLEDVVTEVLMFFDSMIRYSVIPKASLYDTVLILCSTYISTYSYSKLAQSVIFNLISSPVSNLAFENVFNILQYNRSNVNAVRGAVRLMRFLMLQEVKNDAIASITLSSSIEFTEFPLGFNENVDFEILGTVYLFLRTPSILNRLNFLDWHRILNILMYCSQYLPLKASTSKEAFSKTAAFANIYDRVLDFLDFEALIPLLQQFQVKLVFFLKDVLPVLKPKIRKKLLRLFETYNLIFPCNQYWVFNLEFLLGIYQCKTFDLEDRALLFKLVEDACSVADENSAPILCSKFLFPVIESFSKESDDCVVSPVYNMLFFLSVNFQNPGLKDCIDHIFQQLISDTSSVTVRRLATSTLIRLFYYYYDLRDAVPIQETLAKMLEILETPSFPFVSRMLCLQFFLRFRANGTSIYICENIDLNEPFKVLNVDSELIPAVYPISDSFVNSATVEKHIWERKENDLIKISNHSTEYGKDFVTFPTSSLLRFYRKSMATESNWTILMFMITHLADQISNRSMFIGALEEIYNLLDFMCDIVFERVSISAEIPSNIRKANIMIPILQNVQMLFVYHDQFSRAQEDELVSVFFAGLQKWNEACHVSIHSLMLCCYELPVSIRKQLPAILVTLSRLITKPDLSVHILEFLCSLARLPDLIANFTDADYRQIFAIALKYIQHRDFTKESKDSNDTESILKNSYSSYVLALAYSVLQIWFLSLRLTERKKFVPWILRGLKLASEGKPLEDLCLVQYDMMQQFCYSNSDINNQTSTFVDSDVESETWIRGNSLFTINVSVNSGFLEAVIRRPTGTTQYTFRNEASLQKFLWEENLTSSKALTRGLLCTPSSFVSHFLDPHGISLYNQPLLLPSNDDSVRRAISVFDRIPVIESLKAGLVYVGYQQRREADILANTNPSEDFLTFLNGLGTLFELKTDQKVFAGGLDRENDIDGAFAYCWKDKVTQMVFHCTTMMPTNIEHDPGCTLKKRHIGNDFVTIIFNESGLEYDFDTIPSQFNFVNIVITPESESIRRTGRQIKFYKVKALTKYDIDFSLFRRYKIVSSDALPAIVRDVTLNAAVFSHIYHRSAGDYVHIWAERLRQLKRLREKFQASVLPEDYNLDEQTKTKLQNGTNFSDFTSYL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
5Phosphorylation---MNNKSLLDLSSE
---CCCCCCCCCCCC		35.9724763107
1034PhosphorylationFLWEENLTSSKALTR
HHHHCCCCCCCCHHC		42.4024763107
1035PhosphorylationLWEENLTSSKALTRG
HHHCCCCCCCCHHCC		32.7621712547
1036PhosphorylationWEENLTSSKALTRGL
HHCCCCCCCCHHCCC		19.4028889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TSC2_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TSC2_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TSC2_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
FNTB_SCHPOcpp1genetic
16624901
RHB1_SCHPOrhb1genetic
14718525
CGP1_SCHPOpas1genetic
16115814
FKBP_SCHPOfkh1genetic
17179073
TSC1_SCHPOtsc1physical
12136010
RHB1_SCHPOrhb1genetic
18219492
TOR2_SCHPOtor2genetic
17261596
STE11_SCHPOste11genetic
16624901
YKT6_SCHPOykt6genetic
16624901
ZFS1_SCHPOzfs1genetic
16624901
GGPPS_SCHPOspo9genetic
16624901
FNTA_SCHPOcwp1genetic
16624901
GCN5_SCHPOgcn5genetic
22992726
DHE4_SCHPOgdh1genetic
22681890
ADN3_SCHPOadn3genetic
22681890
YCJ3_SCHPOSPCC63.03genetic
22681890
TPP1_SCHPOtpp1genetic
22681890
VHT1_SCHPOvht1genetic
22681890
NU132_SCHPOnup132genetic
22681890
REB1_SCHPOreb1genetic
22681890
ILVB_SCHPOilv1genetic
22681890
AP3B_SCHPOapl6genetic
22681890
6PGL_SCHPOSPCC16C4.10genetic
22681890
YH51_SCHPOSPBC215.01genetic
22681890
ALY1_SCHPOSPBC839.02genetic
22681890
VAM7_SCHPOSPCC594.06cgenetic
22681890
PROB_SCHPOSPAC17H9.13cgenetic
22681890
ARP6_SCHPOarp6genetic
22681890
YFY2_SCHPOSPAC9.02cgenetic
22681890
AP3M_SCHPOapm3genetic
22681890
APT_SCHPOapt1genetic
22681890
MGR2_SCHPOmgr2genetic
22681890
VIP1_SCHPOasp1genetic
22681890
ARP8_SCHPOarp8genetic
22681890
UBP11_SCHPOubp11genetic
22681890
YGRG_SCHPOSPBC365.16genetic
22681890
YF98_SCHPOnht10genetic
22681890
GYP1_SCHPOgyp1genetic
22681890
YNS7_SCHPOSPBC18H10.07genetic
22681890
YAQD_SCHPOSPAC18G6.13genetic
22681890
CSN1_SCHPOcsn1genetic
22681890
FT105_SCHPOftp105genetic
22681890
ARP42_SCHPOarp42genetic
22681890
BCA1_SCHPOeca39genetic
22681890
AP3D_SCHPOapl5genetic
22681890
NOT3_SCHPOnot3genetic
22681890
RL43B_SCHPOrpl4302genetic
22681890
YOOH_SCHPOSPBC887.17genetic
22681890
ZFS1_SCHPOzfs1genetic
22681890
PANE_SCHPOSPBPB2B2.09cgenetic
22681890
PTR2_SCHPOptr2genetic
22681890
AROG_SCHPOSPAP8A3.07cgenetic
22681890
YOR2_SCHPOrng9genetic
22681890
AATM_SCHPOSPBC725.01genetic
22681890
CYB51_SCHPOSPBC29A10.16cgenetic
22681890
YCF8_SCHPOSPCC1393.08genetic
22681890
ADN2_SCHPOadn2genetic
22681890
PYRD_SCHPOura3genetic
22681890
YGVA_SCHPOdef1genetic
22681890
HSP71_SCHPOssa1genetic
22681890
H2A1_SCHPOhta1genetic
22681890
SET1_SCHPOset1genetic
22681890
PTPA1_SCHPOypa1genetic
22681890
YBAC_SCHPOrud3genetic
22681890
SHR3_SCHPOpsh3genetic
22681890
YCUD_SCHPOSPCC965.13genetic
22681890
YFY7_SCHPOSPAC9.07cgenetic
22681890
FFT3_SCHPOfft3genetic
22681890
H2AZ_SCHPOpht1genetic
22681890
YHEI_SCHPOSPBPB2B2.18genetic
22681890
SPN1_SCHPOspn1genetic
22681890
MVP1_SCHPOmvp1genetic
22681890
PRS10_SCHPOrpt4genetic
22681890
MPC1_SCHPOmpc1genetic
22681890
AREH2_SCHPOare2genetic
22681890
RHP23_SCHPOrhp23genetic
22681890
YFFE_SCHPOSPAC1687.14cgenetic
22681890
YDA3_SCHPOSPAC1F12.03cgenetic
22681890
RCD1_SCHPOrcd1genetic
22681890
AMT2_SCHPOamt2genetic
22681890
MAD1_SCHPOmad1genetic
22681890
LEU3_SCHPOleu1genetic
12136010
PUR6_SCHPOade6genetic
12136010
CAT1_SCHPOcat1genetic
23934889
ISP7_SCHPOisp7genetic
24344203
GTR1_SCHPOgtr1genetic
24344203
GTR2_SCHPOgtr2genetic
24344203
TOR2_SCHPOtor2genetic
24344203
YNSK_SCHPOany1genetic
23813957
PUB1_SCHPOpub1genetic
23813957
YNSK_SCHPOany1genetic
24876389
TOR2_SCHPOtor2genetic
26447710
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TSC2_SCHPO

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1036, AND MASSSPECTROMETRY.

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