STE11_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: STE11_SCHPO
• UniProt AC: P36631
• Protein Name: Transcription factor ste11
• Gene Name: ste11
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 468
• Subcellular Localization: Nucleus . Cytoplasm . Accumulates in the nucleus under conditions of nitrogen starvation and in the presence of mating pheromones.
• Protein Description: Key transcription factor for sexual development. Activates the transcription of the matp, matm, mei2, mfm, ste6 and rgs1 genes. Binds specifically to a DNA fragment carrying a 10-base motif 5'-TTCTTTGTTY-3'..
• Protein Sequence: MSASLTAEQKDQKSSVKRPLNSFMLYRRDRQAEIPTSNHQSISRIIGQLWRNESAQVKKYYSDLSALERQKHMLENPEYKYTPKKRSTVRRRHKKVSPSSGSFVASDYVVLQQIAQSSKTLKQTEPEKPVNEEETLAALLAPALSYPKSGKSNLIETSELSCLSSSPMIRSHTIPSLSFTDQVSTTISTLDKSEQAPSSLGIYYRSPSSGSPIGRTKSVCLANKARIVPKRSMSSDGCVDKSYQMSKTPSLEANLPQNSSNCSARRVPKFDSKGTVSEQSNSDSPELSADKVLSHCSPIDARPSTPSCPNASISPKTPNTGDHYGFDGAEYLGTPLSVGSTTAYLYGQETELLSTPYCHTSYPAMSRLNSSSGYTCVSSSSVTNSGHTENNTWRSDEQSKGFVDINSFSQSLFSNGNYEFAAHSQELDDLFSQITDFTSTDPIASSLKDANSLGPSLLEPWLPNSNLF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
81	Phosphorylation	LENPEYKYTPKKRST HHCCCCCCCCCCHHH	27.63	21712547
82	Phosphorylation	ENPEYKYTPKKRSTV HCCCCCCCCCCHHHH	25.20	21712547
97	Phosphorylation	RRRHKKVSPSSGSFV HHHCCCCCCCCCCCH	28.13	24763107
99	Phosphorylation	RHKKVSPSSGSFVAS HCCCCCCCCCCCHHH	39.56	21712547
100	Phosphorylation	HKKVSPSSGSFVASD CCCCCCCCCCCHHHH	41.67	21712547
108	Phosphorylation	GSFVASDYVVLQQIA CCCHHHHHHHHHHHH	7.03	21712547
173	Phosphorylation	SPMIRSHTIPSLSFT CCCCCCCCCCCCCCC	35.51	28889911
203	Phosphorylation	APSSLGIYYRSPSSG CCCCCEEEEECCCCC	7.33	21712547
206	Phosphorylation	SLGIYYRSPSSGSPI CCEEEEECCCCCCCC	17.01	24763107
208	Phosphorylation	GIYYRSPSSGSPIGR EEEEECCCCCCCCCC	48.88	24763107
209	Phosphorylation	IYYRSPSSGSPIGRT EEEECCCCCCCCCCC	46.83	28889911
211	Phosphorylation	YRSPSSGSPIGRTKS EECCCCCCCCCCCHH	18.45	28889911
218	Phosphorylation	SPIGRTKSVCLANKA CCCCCCHHHHHHCCC	19.90	28889911
234	Phosphorylation	IVPKRSMSSDGCVDK ECCCCCCCCCCCCCH	26.90	29996109
248	Phosphorylation	KSYQMSKTPSLEANL HHHCCCCCCCCCCCC	15.71	29996109
250	Phosphorylation	YQMSKTPSLEANLPQ HCCCCCCCCCCCCCC	44.03	29996109
277	Phosphorylation	FDSKGTVSEQSNSDS CCCCCCCCCCCCCCC	29.74	29996109
284	Phosphorylation	SEQSNSDSPELSADK CCCCCCCCCCCCHHH	21.79	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of STE11_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of STE11_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of STE11_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MTMI3_SCHPO	mat1-Mi	physical	9233811
MATMI_SCHPO	mat1-Mi	physical	9233811
RAD24_SCHPO	rad24	genetic	11702950
RAD24_SCHPO	rad24	physical	11702950
SPK1_SCHPO	spk1	physical	15713656

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-209 AND SER-211, ANDMASS SPECTROMETRY.
PubMed: 18257517