TSC1_SCHPO - dbPTM
TSC1_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TSC1_SCHPO
UniProt AC Q09778
Protein Name Tuberous sclerosis 1 protein homolog
Gene Name tsc1
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 899
Subcellular Localization Cytoplasm .
Protein Description Together with tsc2, required for uptake of various amino acids from the environment and for proper conjugation. Involved in induction of gene expression of permeases and genes required for meiosis upon nitrogen starvation. May act as a GTPase-activating protein (GAP) for the small GTPase rhb1..
Protein Sequence MPLQSLVKALWNVLHEEESEGYPDLTELIAEVESYQQRYPKQNPTNSQKIRHILDEIYEKTPFNNTRRRILWLAVLKTVIPLLILDRQAVGEWWDQIFFPFLNSPTQLKPVFSDLKSILFYILIFHDEDEWGGDLRRECAEETITRLVDLYVSKAIENLGDVESQEQRNQTIECLVNVLVHYGIQRPKELSSCFCHHFLNPPTRIPILSVMVEVIRRQGPRLYEIPQTGFYDLVLKCAEFDTSPILLSYALSFILMILSHICNSLDDSLYRLFCIYLRFSMIDPTSGFPSSTASGNWEVFHDFMSTYASTTTSQTDSSYNDVHDIVGSSQPDYLESLDYSQLFSILYALYPINFLEFLRDPKLYASKHNFQIRYSFNQELLSTKSDGLLGRHLAHSNFLKYTAETELTDKSRWTRLDSIAVVALCNSLNAVGIAESVMDPFGGKLPTTYEETSSATGLLAYPNESHDIASEPFSISWPQNPSISGSVHSATTFDKAQLSNTEDSYDNISHGTSYSEGVSSIHMVKGERGSNNLELTSESLSSTNDTIRRLQRDLLFLQNELRFEKFVRQQHLQNIGKLHREHILDMAVESERQKLLLTNKRYKAQIELLNSEIDKHRSESQAALNRRVKWENDFNNKIKALREEKKAWKSEESELKSSIESLISQLESIRNSQIDIAFSKNQLELKLQLYETKLKEYEQHLSCVNISKKQVSSSSDTSFGNTKMDSSMILSNSEAVSDEQERELIESEKHRMKLESENLHLQANIELLKKDLEAINVVYEAKIFDLEKRLSSEANAPELHNPVNLNYDAQLSKISEIKENYDELLTRYRELEGKFLESQAEVEELKNFQKPLVDTGSSIHSSPGLQQSKFIIRNDSLHPKVGPPRRQSTDTSRSTFRQY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
504PhosphorylationQLSNTEDSYDNISHG
HHCCCCCCCCCCCCC		28.3121712547
519PhosphorylationTSYSEGVSSIHMVKG
CCCCCCCCEEEEEEC		34.1421712547
726PhosphorylationFGNTKMDSSMILSNS
CCCCCCCCHHCCCCC		20.5021712547
727PhosphorylationGNTKMDSSMILSNSE
CCCCCCCHHCCCCCC		12.9421712547
855PhosphorylationFQKPLVDTGSSIHSS
CCCCCCCCCCCCCCC		31.3324763107
857PhosphorylationKPLVDTGSSIHSSPG
CCCCCCCCCCCCCCC		28.3621712547
858PhosphorylationPLVDTGSSIHSSPGL
CCCCCCCCCCCCCCC		26.1821712547
861PhosphorylationDTGSSIHSSPGLQQS
CCCCCCCCCCCCCCC		36.2421712547
862PhosphorylationTGSSIHSSPGLQQSK
CCCCCCCCCCCCCCC		14.6121712547
868PhosphorylationSSPGLQQSKFIIRND
CCCCCCCCCEEEECC		19.3021712547
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TSC1_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TSC1_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TSC1_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CGP1_SCHPOpas1genetic
16115814
RHB1_SCHPOrhb1genetic
16115814
TSC2_SCHPOtsc2physical
12136010
ADN3_SCHPOadn3genetic
22681890
TPP1_SCHPOtpp1genetic
22681890
VHT1_SCHPOvht1genetic
22681890
PCK1_SCHPOpck1genetic
22681890
TCO89_SCHPOtco89genetic
22681890
YDO6_SCHPOSPAC15A10.06genetic
22681890
ILVB_SCHPOilv1genetic
22681890
AP3B_SCHPOapl6genetic
22681890
6PGL_SCHPOSPCC16C4.10genetic
22681890
ARP6_SCHPOarp6genetic
22681890
PDX1_SCHPOsnz1genetic
22681890
SKH1_SCHPOpek1genetic
22681890
AP3M_SCHPOapm3genetic
22681890
APT_SCHPOapt1genetic
22681890
VIP1_SCHPOasp1genetic
22681890
YGRG_SCHPOSPBC365.16genetic
22681890
GYP1_SCHPOgyp1genetic
22681890
HOB3_SCHPOhob3genetic
22681890
EXO1_SCHPOexo1genetic
22681890
YL88_SCHPOSPAC25B8.08genetic
22681890
FT105_SCHPOftp105genetic
22681890
TOC1_SCHPOtoc1genetic
22681890
SET3_SCHPOset3genetic
22681890
BCA1_SCHPOeca39genetic
22681890
AP3D_SCHPOapl5genetic
22681890
RL43B_SCHPOrpl4302genetic
22681890
YF19_SCHPOatd1genetic
22681890
YOOH_SCHPOSPBC887.17genetic
22681890
ZFS1_SCHPOzfs1genetic
22681890
SSN3_SCHPOsrb10genetic
22681890
SCS7_SCHPOscs7genetic
22681890
PEX6_SCHPOpex6genetic
22681890
PTR2_SCHPOptr2genetic
22681890
AROG_SCHPOSPAP8A3.07cgenetic
22681890
CYB51_SCHPOSPBC29A10.16cgenetic
22681890
YCF8_SCHPOSPCC1393.08genetic
22681890
ADN2_SCHPOadn2genetic
22681890
POF3_SCHPOpof3genetic
22681890
YGVA_SCHPOdef1genetic
22681890
YQ9H_SCHPOSPCC18.17cgenetic
22681890
PTPA1_SCHPOypa1genetic
22681890
YBAC_SCHPOrud3genetic
22681890
GLD1_SCHPOgld1genetic
22681890
SHR3_SCHPOpsh3genetic
22681890
SAT1_SCHPOsat1genetic
22681890
FFT3_SCHPOfft3genetic
22681890
RPB9_SCHPOrpb9genetic
22681890
POF15_SCHPOpof15genetic
22681890
H2AZ_SCHPOpht1genetic
22681890
SPN1_SCHPOspn1genetic
22681890
MID1_SCHPOmid1genetic
22681890
PRS10_SCHPOrpt4genetic
22681890
MPC1_SCHPOmpc1genetic
22681890
AREH2_SCHPOare2genetic
22681890
OMH6_SCHPOomh6genetic
22681890
LEU3_SCHPOleu1genetic
12136010
PUR6_SCHPOade6genetic
12136010
ISP7_SCHPOisp7genetic
24344203
RHB1_SCHPOrhb1genetic
24344203
TSC1_SCHPOtsc1physical
23857276
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TSC1_SCHPO

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Related Literatures of Post-Translational Modification

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