| UniProt ID | TOC1_SCHPO | |
|---|---|---|
| UniProt AC | Q9HDW0 | |
| Protein Name | Target of rapamycin complex 1 subunit toc1 {ECO:0000303|PubMed:18076573} | |
| Gene Name | toc1 {ECO:0000303|PubMed:18076573} | |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). | |
| Sequence Length | 430 | |
| Subcellular Localization | Cytoplasm . | |
| Protein Description | Component of TORC1, which regulates multiple cellular processes to control cell growth in response to environmental signals. Tor2 is essential for growth. Nutrient limitation and environmental stress signals cause inactivation of TORC1. Active TORC1 positively controls cell growth and ribosome biogenesis by regulating ribosomal protein gene expression. TORC1 negatively controls G1 cell-cycle arrest, sexual development and amino acid uptake. Represses mating, meiosis and sporulation efficiency by interfering with the functions of the transcription factor ste11 and the meiosis-promoting RNA-binding protein mei2.. | |
| Protein Sequence | MQLQSPFGDGISCECLNIRVLGIPNETKHQWIFVPRDLIKIKIYSLLQICKAENCSAVACRGCNLCILAVQGNIEISEEPQKLFQEENVKVYIYDSAISLSSVRASFPISELGIRMDIIKARAEPREDEIRASFSSLVNKEIKRTVEELLLSKRSTNRLSLLAFMRNQQLNYEAYETKLLEDASTIEKSLEKEVKTIYDSNIASPKESSDAIDADHAMIDESRSTQRRKSKPKKHVAFTDEYQVAFSDKPGKYFNQPMQYSKQFKLDNPDYEASSDSLNDIENLSTLTFRSDEELEFDFDTNNINNNKSGDSLEMSTTIPSDEENEDFTSKVDAMEIHSGSLPLNIDSSPIFTNHSPSSSLSSESSFEASPSSFVDRKNRWIQMLKKADEHSRSIQARSMGYVLSDDLDNSKAFRPYKQSFLAQGWKSLN | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 198 | Phosphorylation | EKEVKTIYDSNIASP HHHHHHHHHCCCCCC | 27738172 | ||
| 200 | Phosphorylation | EVKTIYDSNIASPKE HHHHHHHCCCCCCCC | 27738172 | ||
| 204 | Phosphorylation | IYDSNIASPKESSDA HHHCCCCCCCCCCCC | 28889911 | ||
| 321 | Phosphorylation | EMSTTIPSDEENEDF EEECCCCCCCCCCCC | 28889911 | ||
| 329 | Phosphorylation | DEENEDFTSKVDAME CCCCCCCCCCCCEEE | 25720772 | ||
| 392 | Phosphorylation | LKKADEHSRSIQARS HHHHHHHHHHHHHHH | 24763107 | ||
| 394 | Phosphorylation | KADEHSRSIQARSMG HHHHHHHHHHHHHHC | 24763107 | ||
| 399 | Phosphorylation | SRSIQARSMGYVLSD HHHHHHHHHCEEECC | 28889911 | ||
| 402 | Phosphorylation | IQARSMGYVLSDDLD HHHHHHCEEECCCCC | 21712547 | ||
| 405 | Phosphorylation | RSMGYVLSDDLDNSK HHHCEEECCCCCCCC | 25720772 | ||
| 428 | Phosphorylation | FLAQGWKSLN----- HHHHHHHHCC----- | 25720772 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TOC1_SCHPO !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TOC1_SCHPO !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TOC1_SCHPO !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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