| UniProt ID | ETT1_SCHPO | |
|---|---|---|
| UniProt AC | Q9USJ7 | |
| Protein Name | Negative regulator of ofd1 | |
| Gene Name | nro1 | |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). | |
| Sequence Length | 393 | |
| Subcellular Localization | Cytoplasm. Nucleus. | |
| Protein Description | Required for correct translation termination (By similarity). Positive regulator of the stability of the N-terminal transcription factor domain (Sre1N) of sre1 which is released from the membrane and enters the nucleus to activate hypoxic gene expression. Acts also as a direct inhibitor of ofd1. Functions probably by inhibiting the ability of the ofd1 to accelerate Sre1N degradation in absence of oxygen.. | |
| Protein Sequence | MIGRRPQGLRAAASLKKQQQLEKQKQEASYELSGNSSPSKENGSENVDNGEMEDETMLVYTEEDNISQLWGLYEMSREKLENDDIDASVSLVFGTIHEADRILRNTEDISTLPKDFHAAYSSALLAVSELFEIAQKRLKETNTEESYIDAAIERAQLGLDAPGNESRLFLALARAYLEKVRVLVWRHDNEESLANIPVTQLVNPYIEKAIQYLRPLAQDSTEYFDALTPDSLRPLYILSSYLFQFGDQFSEAFLLDVCSIITALWLKSVVDPNTPAYYKLIAQEAVLNNYTTFAEYYMDLLDNSESNVDDLINKASSWLNNSVDTWNVIYTLDKSPERLLKLADIKMDLAQIVQDEASQDNYLKEACNAIKEAQGSGVELSPDYVEFVEAYSA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 29 | Phosphorylation | EKQKQEASYELSGNS HHHHHHHHHHCCCCC | 20.56 | 29996109 | |
| 30 | Phosphorylation | KQKQEASYELSGNSS HHHHHHHHHCCCCCC | 28.12 | 21712547 | |
| 33 | Phosphorylation | QEASYELSGNSSPSK HHHHHHCCCCCCCCC | 24.80 | 21712547 | |
| 36 | Phosphorylation | SYELSGNSSPSKENG HHHCCCCCCCCCCCC | 47.34 | 24763107 | |
| 37 | Phosphorylation | YELSGNSSPSKENGS HHCCCCCCCCCCCCC | 36.87 | 24763107 | |
| 39 | Phosphorylation | LSGNSSPSKENGSEN CCCCCCCCCCCCCCC | 55.33 | 21712547 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ETT1_SCHPO !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ETT1_SCHPO !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ETT1_SCHPO !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| OFD1_SCHPO | ofd1 | physical | 21481773 | |
| DDB1_SCHPO | ddb1 | genetic | 22681890 | |
| FHL1_SCHPO | fhl1 | genetic | 22681890 | |
| HOB3_SCHPO | hob3 | genetic | 22681890 | |
| TOC1_SCHPO | toc1 | genetic | 22681890 | |
| YEEB_SCHPO | SPAC19A8.11c | genetic | 22681890 | |
| YBLC_SCHPO | SPBC106.12c | genetic | 22681890 | |
| RLA2_SCHPO | rpp201 | genetic | 22681890 | |
| ELP3_SCHPO | elp3 | genetic | 22681890 | |
| YIDH_SCHPO | SPAC227.17c | genetic | 22681890 | |
| MBX1_SCHPO | mbx1 | genetic | 22681890 | |
| GMA12_SCHPO | gma12 | genetic | 22681890 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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