TCO89_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TCO89_SCHPO
• UniProt AC: O74428
• Protein Name: Target of rapamycin complex 1 subunit tco89 {ECO:0000303|PubMed:18076573}
• Gene Name: tco89 {ECO:0000303|PubMed:18076573}
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 451
• Subcellular Localization: Cytoplasm . Localizes at the barrier septum.
• Protein Description: Component of TORC1, which regulates multiple cellular processes to control cell growth in response to environmental signals. Tor2 is essential for growth. Nutrient limitation and environmental stress signals cause inactivation of TORC1. Active TORC1 positively controls cell growth and ribosome biogenesis by regulating ribosomal protein gene expression. TORC1 negatively controls G1 cell-cycle arrest, sexual development and amino acid uptake. Represses mating, meiosis and sporulation efficiency by interfering with the functions of the transcription factor ste11 and the meiosis-promoting RNA-binding protein mei2..
• Protein Sequence: MERPSLSRRTSSSTVSTDGEGVYSRSTKERKRNFIVNSRLKRGGGHVRVNRSGRLGSVTMRPSALTRAHSQNPNSSLVNNSSAVSHLTKQRSLNDLHELNGPKHVAKNGLIPLTQRKPNCVWDDAPVDNDSTAGNLDSDSALPTPSVTTNEAADSSRASSPVTRVVAVHDNKKKIINSNISNAPPFNNTDVQASARPPAAGQDDSAADASTTKSSPVHNEVMAEPLPHSNNREVTQATNQPKWQIHSGSDIASEPPTLSRGNSLSLLANRKVPSTNVKKSQAELYDLGSSTSRTQQKLLIQRASSKFDIVEDDMDTNPSKRFSNPHTKHIMDLVRTQYRNVLRTRELIPEFLEKIRSSYSNNQNFDSQNAFNTSAAGTAGTREETISNGQNGIVASAETSKKDDGVQSASLNASMSARSHARQRSIHVPKTRKDTDYESIHQKLLQLWSQG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MERPSLSRRTSS ---CCCCCCCCCCCC		21712547
7	Phosphorylation	-MERPSLSRRTSSST -CCCCCCCCCCCCCE		21712547
10	Phosphorylation	RPSLSRRTSSSTVST CCCCCCCCCCCEECC		21712547
11	Phosphorylation	PSLSRRTSSSTVSTD CCCCCCCCCCEECCC		29996109
12	Phosphorylation	SLSRRTSSSTVSTDG CCCCCCCCCEECCCC		25720772
13	Phosphorylation	LSRRTSSSTVSTDGE CCCCCCCCEECCCCC		29996109
14	Phosphorylation	SRRTSSSTVSTDGEG CCCCCCCEECCCCCC		25720772
16	Phosphorylation	RTSSSTVSTDGEGVY CCCCCEECCCCCCCC		29996109
17	Phosphorylation	TSSSTVSTDGEGVYS CCCCEECCCCCCCCC		21712547
57	Phosphorylation	NRSGRLGSVTMRPSA CCCCCCCEEEECHHH		29996109
70	Phosphorylation	SALTRAHSQNPNSSL HHHHHHHHCCCCCCC		28889911
75	Phosphorylation	AHSQNPNSSLVNNSS HHHCCCCCCCCCCHH		29996109
76	Phosphorylation	HSQNPNSSLVNNSSA HHCCCCCCCCCCHHH		29996109
81	Phosphorylation	NSSLVNNSSAVSHLT CCCCCCCHHHHHHHH		29996109
82	Phosphorylation	SSLVNNSSAVSHLTK CCCCCCHHHHHHHHC		25720772
92	Phosphorylation	SHLTKQRSLNDLHEL HHHHCCCCHHHHHHH		28889911
146	Phosphorylation	DSALPTPSVTTNEAA CCCCCCCCCCCCHHC		27738172
160	Phosphorylation	ADSSRASSPVTRVVA CHHHCCCCCCEEEEE		27738172
214	Phosphorylation	ADASTTKSSPVHNEV CCCCCCCCCCCCCCC		29996109
215	Phosphorylation	DASTTKSSPVHNEVM CCCCCCCCCCCCCCC		29996109
247	Phosphorylation	QPKWQIHSGSDIASE CCCEEEECCCCCCCC		29996109
249	Phosphorylation	KWQIHSGSDIASEPP CEEEECCCCCCCCCC		25720772
253	Phosphorylation	HSGSDIASEPPTLSR ECCCCCCCCCCCCCC		29996109
257	Phosphorylation	DIASEPPTLSRGNSL CCCCCCCCCCCCCCH		21712547
259	Phosphorylation	ASEPPTLSRGNSLSL CCCCCCCCCCCCHHH		21712547
263	Phosphorylation	PTLSRGNSLSLLANR CCCCCCCCHHHHHCC		28889911
265	Phosphorylation	LSRGNSLSLLANRKV CCCCCCHHHHHCCCC		21712547
280	Phosphorylation	PSTNVKKSQAELYDL CCCCCCHHHHHHHHC		24763107
304	Phosphorylation	KLLIQRASSKFDIVE HHHHHHHHHCCCEEE		24763107
305	Phosphorylation	LLIQRASSKFDIVED HHHHHHHHCCCEEEC		24763107
408	Phosphorylation	KKDDGVQSASLNASM CCCCCCCCHHHCHHH		28889911
410	Phosphorylation	DDGVQSASLNASMSA CCCCCCHHHCHHHHH		25720772
414	Phosphorylation	QSASLNASMSARSHA CCHHHCHHHHHHHHH		28889911
425	Phosphorylation	RSHARQRSIHVPKTR HHHHHHHCCCCCCCC		29996109
439	Phosphorylation	RKDTDYESIHQKLLQ CCCCCHHHHHHHHHH		24763107
449	Phosphorylation	QKLLQLWSQG----- HHHHHHHHCC-----		19547744

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TCO89_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TCO89_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TCO89_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GSK3_SCHPO	gsk3	genetic	28281664

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.