dbPTM

AP3B_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	AP3B_SCHPO
UniProt AC	O13939
Protein Name	AP-3 complex subunit beta
Gene Name	apl6
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	745
Subcellular Localization	Golgi apparatus . Cytoplasmic vesicle, clathrin-coated vesicle membrane Peripheral membrane protein Cytoplasmic side . Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.
Protein Description	Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Beta adaptin is a subunit of the plasma membrane adaptor (By similarity)..
Protein Sequence	MSNLSFFQTLSGLAENAKQIAKSSSLSFEENELSHSDLLRLLNSNSDAGKLEAINFILAQMMHGENMSLYFPDVVKLVASENPEIRRLVHIYLLQYAEFNPDLALLSVNTVQKTLYDKNPLTRSTAIRVMSSIRVPAINGIVLLAIQQCITDTADRVRQSAALAITKCYSLDPSYKSQLEEHIKTLLSDNSPIVVPAALFTFEVVCPEKLEIIHPYYHRICTLFPQMNDWDKVVALKTLVRYARLTLPEPSTPSTHSDLKELLESIKSCFFSLLPSTIIAGARAFYYLAPSNQMHLIVEPLLQLLLEKPIVRTTTLRYISQIVYKTPELFKNHIKSFFLIASDSDDTCLLKINILSRLLDAQNSSQILPELLYYINSHPNPSVASTAVKALGDFASANISMAPSCLNTLLLLLKSHNSLIVTEAASSLRLLIHNDPKEIYLQYLAATYETLEVPRAKSVTLWLISEHILIIPRLVPDVLRIAVKTFADETLEVKYQILELSVRLYVLSHSEEKQNDLESRDDVVSLLFNYVLSLIHFDMSYDLRDRARFYKELASTPSSEFTRRIVLESKGNSQKEIIASRDYCIGTASLCLNEDVMGYEPIPNWADVSDLPPDSVREGIKDVLPINPHTGNIYSNNSPGVKALSSDNFKRDFGDTNAINRPKFVGQQTLEEFYASETSESSEGEYETSTSESEDEETDDTSQEEDNEKNSTPDEDTENNNTSSISTKSIMDRPLTEPEPNYWQS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
630	Phosphorylation	VLPINPHTGNIYSNN CCCCCCCCCCCCCCC	32.93	29996109
634	Phosphorylation	NPHTGNIYSNNSPGV CCCCCCCCCCCCCCC	14.89	21712547
635	Phosphorylation	PHTGNIYSNNSPGVK CCCCCCCCCCCCCCE	26.24	25720772
638	Phosphorylation	GNIYSNNSPGVKALS CCCCCCCCCCCEECC	27.55	28889911
645	Phosphorylation	SPGVKALSSDNFKRD CCCCEECCCCCCCCC	40.27	28889911
646	Phosphorylation	PGVKALSSDNFKRDF CCCEECCCCCCCCCC	37.11	29996109
711	Phosphorylation	EEDNEKNSTPDEDTE HHHHCCCCCCCCCCC	53.00	21712547
712	Phosphorylation	EDNEKNSTPDEDTEN HHHCCCCCCCCCCCC	44.12	25720772
724	Phosphorylation	TENNNTSSISTKSIM CCCCCCCCCCCHHHH	20.65	25720772
726	Phosphorylation	NNNTSSISTKSIMDR CCCCCCCCCHHHHCC	31.56	24763107
729	Phosphorylation	TSSISTKSIMDRPLT CCCCCCHHHHCCCCC	24.19	24763107
736	Phosphorylation	SIMDRPLTEPEPNYW HHHCCCCCCCCCCCC	52.77	29996109

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of AP3B_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of AP3B_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of AP3B_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of AP3B_SCHPO !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of AP3B_SCHPO

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of fission yeast."; Wilson-Grady J.T., Villen J., Gygi S.P.; J. Proteome Res. 7:1088-1097(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-638, AND MASSSPECTROMETRY.	18257517 [Abstract]