LEU3_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LEU3_SCHPO
• UniProt AC: P18869
• Protein Name: 3-isopropylmalate dehydrogenase
• Gene Name: leu1
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 371
• Subcellular Localization: Cytoplasm.
• Protein Description: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate..
• Protein Sequence: MCAKKIVVLPGDHIGPEIVASALEVLKVVEKKRPELKLEFEEHKIGGASIDAYGTPLTDETVKACLEADGVLLGAVGGPEWTNPNCRPEQGLLKLRKSMGVWANLRPCNFASKSLVKYSPLKPEIVEGVDFCVVRELTGGCYFGERTEDNGSGYAMDTWPYSLEEVSRIARLAAWLAETSNPPAPVTLLDKANVLATSRLWRKTVAKIFKEEYPHLTLKNQLIDSAAMLLVKSPRTLNGVVLTDNLFGDIISDEASVIPGSLGLLPSASLSGVVGKSEEKVHCLVEPIHGSAPDIAGKGIVNPVGTILSASLLLRYGLNAPKEAEAIEAAVRKVLDDTSIGGRGLYTRDLGGEASTADITKAVVEELEKIL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
55	Phosphorylation	ASIDAYGTPLTDETV EEEECCCCCCCHHHH	11.49	28889911
138	Phosphorylation	FCVVRELTGGCYFGE EEEEEECCCCCEECC	27.12	28889911
225	Phosphorylation	LKNQLIDSAAMLLVK HHHHHHHHHHHHHHC	15.78	25720772
233	Phosphorylation	AAMLLVKSPRTLNGV HHHHHHCCCCCCCCE	16.49	25720772
355	Phosphorylation	RDLGGEASTADITKA CCCCCCCCHHHHHHH	21.59	25720772

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LEU3_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LEU3_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LEU3_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
WIS1_SCHPO	wis1	genetic	15466417
HOG1_SCHPO	sty1	genetic	15466417
GCN5_SCHPO	gcn5	genetic	22992726
ADA2_SCHPO	ada2	genetic	22992726
NGG1_SCHPO	ngg1	genetic	22992726
SGF29_SCHPO	sgf29	genetic	22992726
SGF73_SCHPO	sgf73	genetic	22992726
TRA1_SCHPO	tra1	genetic	22992726
SPT8_SCHPO	spt8	genetic	22992726
CLR3_SCHPO	clr3	genetic	22992726
PHD1_SCHPO	hos2	genetic	22992726
TOR1_SCHPO	tor1	genetic	15466417
LEU3_SCHPO	leu1	physical	26771498
NC2B_SCHPO	SPBC30D10.02	physical	26771498

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-55, AND MASSSPECTROMETRY.
PubMed: 18257517