dbPTM

SPT8_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SPT8_SCHPO
UniProt AC	O60097
Protein Name	Transcription factor spt8
Gene Name	spt8
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	526
Subcellular Localization	Cytoplasm . Nucleus .
Protein Description	Functions as a component of the transcription regulatory histone acetylation (HAT) complex SAGA. SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes. At the promoters, SAGA is required for recruitment of the basal transcription machinery (By similarity)..
Protein Sequence	MEAEESESFSYPMLLPSDGLYPEDDDDADMDQDKNPEENVMNEKEDEDVDAVDEKSGEEDVEMDTMEDENENDEDTEQTSEKKETEETPKENPLEKLKQKASTASFYDVVPTLAIPMATSINAFAFTSDLKWLFTGGEDGYIRKYDFFPSINGDLSLTVAQRHPFVDTVTKAGILLNYWENAYDGNKPSSVYSLAAHSRGLWVLSGVNNGDIILYSTRHQEGYPVTSLKKHTAPVSCLALHGSEKKVLSGSWDKMVYYWDLNTGDAISTYNCESGQISNIVYRPSGAVNPWGSESDDMRSLFGTPASSSSYDALFDEEVEKAIEEETKSVQANEENETEKPSQTESTTNNDNIKAPSESSSEESNIFLTTSIDGVMNVWDHRMVDSVLKYPVPKGVPPWAMSACWSPDGNNIYIGRRNGIVEEYNIHSGKEPVRSLKMPLDSGPVSNVYSMPNGRHLVISSFDNIRLYDLQSKAGIGFLIIPGHHGGLVSSLYVDTSCQFMFSASGNRGWQGTTTEVFLGYQIMTS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
329	Phosphorylation	AIEEETKSVQANEEN HHHHHHHHCCCCCCC	27.21	24763107

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SPT8_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SPT8_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SPT8_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
WEE1_SCHPO	wee1	genetic	10392445
GCN5_SCHPO	gcn5	genetic	21642955
SPT7_SCHPO	spt7	physical	26771498

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SPT8_SCHPO

Related Literatures of Post-Translational Modification