TOR2_SCHPO - dbPTM
TOR2_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TOR2_SCHPO
UniProt AC Q9Y7K2
Protein Name Serine/threonine-protein kinase tor2 {ECO:0000305|PubMed:11096119}
Gene Name tor2 {ECO:0000303|PubMed:11096119}
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 2337
Subcellular Localization Cytoplasm .
Protein Description Phosphatidylinositol 3-kinase homolog, component of TORC1, which regulates multiple cellular processes to control cell growth in response to environmental signals. TORC1 controls the switch between cell proliferation and differentiation by sensing nutrient availability. Nutrient limitation and environmental stress signals cause inactivation of TORC1. Active TORC1 positively controls cell growth and ribosome biogenesis by regulating ribosomal protein gene expression. [PubMed: 17121544]
Protein Sequence MKEFPGLKSRNEEIRNKAANDLYEYVIAYSRELSGEALVQFNNDVNKYVYTLIHSTDPLDRLAGVTAINRLIDYEGEDTTRITRFANYLRIILPGTDQKATVLAAKALGRLAVPGGALTSEFVNFEVKRALEWLQGERNENRRYAAVLILKELAKNTSTLIYAHIDSIFELLWHGLRDPKVTIRIASADALSEFLKIVRQRDSSIRLQWYTSILNEAQRGVAQGSSDYIHGSLLVYRQLFLKAGMFMHERYREVSDIILQFRDHKDLLIRKTVTELIATLAAYNPDEFVSNYLHVCMLHLLNLLKKENVKMLAFATIGKVAVAITNSIIPYLDPICDSIKESLKIHIRNKSASDAAIFQCISLLSIALGQAFSNYAYDLFDLIFASGLSEASYRALSDLAHNIPPLLPVIQERLLDMLSKILSGRPFIPPGCPPQYVARSLKSSKSASLKTGFFPNDVYILALKVLGNFDFSGYILNEFVKDCVVVYLENNDPEVRKTASITCSQLFARDPILSQTSDHAIQVVAEVLEKLLTVGICDTVPDIRLTVLNSLDSRFNKHLAQADKIRLLFIAINDENFAVRESALRIIGRLNVYNPAYVMPYLRKIMLKTLTILDYSTIIRTKEENAKLLCLLIAAAPRLIESHVEPILQILLPKAKDSSSIVAASIVNSLGEICQISGEVIVPFIKDLMPLIIEALQDQSSPIRRAAALKALGNLSSSTGYVIDPYIEFPSLLDILIGITKTEQDITIRRETIKLIGTLGALDPNRHRVLEKGTEKVVPEQKNIPPDISLLMSGIGPSSDEYYPTVVITALMSILKDPSLTIHHTAVIQAVMYIFKTMGLRCAPFLSQIIPEFIAVMRTCPTNILEFYFQQLSILVLIVRQHIRSFLPDLFKLIKDFWNPHSNLQFTILSLIESLARAMQGEFKPYLPSLLVMMLQIFDSDVSVDSVSTKKVLHAFIVFGDTLADYFHMLLDPILRLYERNDVSIGIKESIMITIGRLSMVINLSEYASRIIHPVMRMLSCNNASLIRVSMDTVCALIYQLNVDFAIFIPMIDKCLKMNGVTHETYSILVEQFLQEQPLPIKLNPYEKYDKPKLDVVASAADITSKKLPVNQEILRNAWEASQRSTKDDWQEWIRRLGVALLRESPSHALRACAALAAAYQPLARDLFNASFVSCWSELYDHFQEELVKSIEIALTSPHISPEIIQILLNLAEFMEHDDKPLPIDIRTLGAYAAKCHAFAKALHYKELEFIEEELVTKPSVDTIEALISINNQLQQPDAAIGILKHAQQHDKMNLKETWYEKLQRWEDALSAYEKREAAGAGNFEITMGKLRCLHALGEWDRLSQLAQENWIHAGHDARRYIAPLSVAAAWGLGQWEQMDEYISVMKSESPDKAFFNAIVALHRSQFEEAASYITRARDLLDTELTALVGESYNRAYSVAVRVQMLSELEEIITYKKAEDKPEVREMIKKTWVRRLKGCQRNVDVWQRMLRIRSLVISPRDNMEMWIKFANLCRKSGRISLAKKSLNLLLEDDENLDNSLVLKKTHPSIVYANLKFLWAVDDKRKALNSMQEFTSQLISDINVDPALFVQSTSVNTQKSQEEIQYYFHLLARCYHKQGQWQQEIENNWSEGSFDGVLQSYMYATQFDSKWYKAWHSWALANFEAVKFLEQSEEQIPSAAYEQYIIPAVKGFFKSIALSKGNLQDTLRLLNLWFKFGNNSNVINTLNVGISTVNIDIWLDVIPQLIARIHASSLSVRKSVHQLLSDVGRAHPQALVYPLTVAAKSQSSARQNAALAIMDSLKTHSPRLVEQARLVSHELIRAAILWHEQWHEGLEEASRLYFGDHNIEGMFAVLRPLHEMLERGPETLREISFQQAFGRDLVEARDCCIRFEQTGDISDLNQAWDLYYQVFKKIRKQLPQLTTLDLQYVSPKLLHVHDLELAVPGTYVSGKPVIRIVKFYPTFNVITSKQRPRRLSIKGSDGKDYQYVLKGHEDIRQDERVMQLFGLCNNLLLADPETFKRLLSIQRYPVIPLSPDSGLLGWVLDSDTLHVLIRDYRESRKILLNIEHRLIIQMAPDYDRLTLLQKVEVFEYALLSTTGQDLYRVLWLKSRSSEAWLNRRTNYSRTLAVMSMVGYILGLGDRHPSNLMLDRYTGNIIHIDFGDCFEVAMHREKFPEKIPFRLTRMLVNAMEVSGIEGTFRITCEHVMRVLRTNKESVMAVLEAFVYDPLINWRLAPAYSPSIDEKQSNEPNTLLGETIDGLHRKRLNEEGITLEERQKPEILNQRAITVLNRVSNKLTGRDFKPQQQLDVPSQVEKLILQATSIENLCLCYIGWCSFW
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
448PhosphorylationLKSSKSASLKTGFFP
HHCCCCCCCCCCCCC		37.1725720772
1539PhosphorylationDDENLDNSLVLKKTH
CCCCCCCCCCEECCC		21.3718076573
1986PhosphorylationSDGKDYQYVLKGHED
CCCCCCHHHHCCCHH		11.0827738172
2237PhosphorylationNWRLAPAYSPSIDEK
CCEECCCCCCCCCHH		21.7629996109
2238PhosphorylationWRLAPAYSPSIDEKQ
CEECCCCCCCCCHHH		17.8028889911
2240PhosphorylationLAPAYSPSIDEKQSN
ECCCCCCCCCHHHCC		36.4128889911
2256PhosphorylationPNTLLGETIDGLHRK
CCCHHHHHHHHHHHH		23.6721712547
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TOR2_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TOR2_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TOR2_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RUM1_SCHPOrum1genetic
17046992
SRW1_SCHPOsrw1genetic
17046992
RHB1_SCHPOrhb1physical
16262791
WAT1_SCHPOpop3physical
17046992
MIP1_SCHPOmip1physical
17046992
RHB1_SCHPOrhb1physical
17121544
TOC1_SCHPOtoc1physical
18076573
TCO89_SCHPOtco89physical
18076573
MIP1_SCHPOmip1physical
18076573
WAT1_SCHPOpop3physical
18076573
TTI1_SCHPOtti1physical
18076573
TEL2_SCHPOtel2physical
18076573
CSK2A_SCHPOcka1physical
18076573
KAPB_SCHPOpka1genetic
20634885
KAPR_SCHPOcgs1genetic
20634885
MIP1_SCHPOmip1physical
17261596
SIN1_SCHPOsin1physical
17261596
RICTR_SCHPOste20physical
17261596
WAT1_SCHPOpop3physical
17261596
GAD8_SCHPOgad8genetic
17261596
MIP1_SCHPOmip1physical
22645648
TCO89_SCHPOtco89physical
22645648
KS6B1_HUMANRPS6KB1physical
22645648
CUT1_SCHPOcut1genetic
22645648
SECU_SCHPOcut2genetic
22645648
GCN2_SCHPOgcn2genetic
23108671
PSK1_SCHPOpsk1physical
22976295
SCK1_SCHPOsck1physical
22976295
SCK2_SCHPOsck2physical
22976295
YOI5_SCHPOSPBC1778.05cgenetic
22681890
RICTR_SCHPOste20genetic
22681890
MIP1_SCHPOmip1genetic
17261596
YNSK_SCHPOany1genetic
23813957
PUB1_SCHPOpub1genetic
23813957
MEI2_SCHPOmei2genetic
24741065
MEI2_SCHPOmei2physical
24741065
FHL1_SCHPOfhl1genetic
27165118
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TOR2_SCHPO

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2238 AND SER-2240, ANDMASS SPECTROMETRY.

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