SIN1_SCHPO - dbPTM
SIN1_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SIN1_SCHPO
UniProt AC Q9P7Y9
Protein Name Target of rapamycin complex 2 subunit sin1 {ECO:0000305|PubMed:18076573}
Gene Name sin1 {ECO:0000303|PubMed:10428959}
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 665
Subcellular Localization
Protein Description Component of TORC2, which regulates multiple cellular processes to control cell growth in response to environmental signals. TORC2 is required for cell survival under various stress conditions. TORC2 positively controls G1 cell-cycle arrest, sexual development and amino acid uptake. Positively regulates amino acid uptake through the control of expression of amino acid permeases..
Protein Sequence MELTREKVLLLTFLRMQYSHILPDSIENRVISTEAPEWELDKSLQDLLIHDYDYSKTSFSSSPPIVANDTVSNVRKPSDTKQVNGAGGQVNHSRAEDSDYATSDLSESSDVGDDDNSCIFSFSKVPMQKDVASIKEEERLDPKISTLNNIDAIANLKLTNMVESSQAVNLTSSKQSSINQQSSVSTDYDDLRSISEESFHLSQGEIPLTFPMNSSLTDTEADAVVAVDALFPGKQRGTHNTVNKARSVSNAKAPTSALRALLEHKENSSQNGPLAENFATFSGHAESNALRLNIYFPSSESPSKPLFVELRKNVLVSEAIGYILLQYVNQQLVPPIEDEAQNPNYWNLRIVEDDGELDEDFPALDRVGPLSKFGFDAFALVKATPAQIKENQAAYPFKSKHPTSIPEANNKTHIRHTSSTSSQSQKQAQDVKDTLNTSHVVQVRLPPYGDNARFCNIEISKTTRLAMVLNQVCWMKQLERFKYTLRVAGSDTVLPLDKTFSSLDGNPTLELVKKKVRDKKGSTQQLPTSSPQNSVYGSIKKDAQSSTYNATDIMSSNTYQEFLVWKRQPVSFMGRHERLLAIDGEYVHIMPSESKNIFETPKTSSIHAGSIILCKQSKKSPCNFKMIVSKNRETKRYDFEVLSALEAAIIVSRIRALMNTVKKIN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
43PhosphorylationPEWELDKSLQDLLIH
CCCHHCHHHHHHHHC		30.8124763107
57PhosphorylationHDYDYSKTSFSSSPP
CCCCCCCCCCCCCCC		29.1229996109
58PhosphorylationDYDYSKTSFSSSPPI
CCCCCCCCCCCCCCE		27.2025720772
60PhosphorylationDYSKTSFSSSPPIVA
CCCCCCCCCCCCEEC		29.6728889911
61PhosphorylationYSKTSFSSSPPIVAN
CCCCCCCCCCCEECC		44.8729996109
62PhosphorylationSKTSFSSSPPIVAND
CCCCCCCCCCEECCC		33.2328889911
133PhosphorylationPMQKDVASIKEEERL
CCCCCHHHHHHHHHC		33.7618076573
247PhosphorylationNTVNKARSVSNAKAP
HHHHHHHHHCCCCCC		34.4525720772
249PhosphorylationVNKARSVSNAKAPTS
HHHHHHHCCCCCCHH		32.1125720772
384PhosphorylationAFALVKATPAQIKEN
EEEEEECCHHHHHHC		17.2825720772
403PhosphorylationPFKSKHPTSIPEANN
CCCCCCCCCCCCCCC		38.7225720772
404PhosphorylationFKSKHPTSIPEANNK
CCCCCCCCCCCCCCC		40.3718076573
490PhosphorylationYTLRVAGSDTVLPLD
EEEEECCCCCEEECC		21.9928889911
492PhosphorylationLRVAGSDTVLPLDKT
EEECCCCCEEECCCC		26.1629996109
501PhosphorylationLPLDKTFSSLDGNPT
EECCCCCCCCCCCCC		34.9125720772
502PhosphorylationPLDKTFSSLDGNPTL
ECCCCCCCCCCCCCH		26.7018076573
528PhosphorylationGSTQQLPTSSPQNSV
CCCCCCCCCCCCCCC		50.8921712547
529PhosphorylationSTQQLPTSSPQNSVY
CCCCCCCCCCCCCCC		37.7728889911
530PhosphorylationTQQLPTSSPQNSVYG
CCCCCCCCCCCCCCC		32.7428889911
534PhosphorylationPTSSPQNSVYGSIKK
CCCCCCCCCCCCHHH		16.0921712547
536PhosphorylationSSPQNSVYGSIKKDA
CCCCCCCCCCHHHCC		12.6521712547
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SIN1_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SIN1_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SIN1_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
YBPC_SCHPOSPBC16H5.12cgenetic
22681890
PDH1_SCHPOpdh1genetic
22681890
TSC1_SCHPOtsc1genetic
24344203
TSC2_SCHPOtsc2genetic
24344203
GSK3_SCHPOgsk3genetic
28281664
GAD8_SCHPOgad8physical
28264193
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SIN1_SCHPO

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-62, AND MASSSPECTROMETRY.

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