GAD8_SCHPO - dbPTM
GAD8_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GAD8_SCHPO
UniProt AC Q9P7J8
Protein Name Serine/threonine-protein kinase gad8 {ECO:0000303|PubMed:12805221}
Gene Name gad8 {ECO:0000303|PubMed:12805221}
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 569
Subcellular Localization
Protein Description Involved in a signaling module for sexual development and cell growth under stressed conditions. Required for G1 arrest under nitrogen starvation and for growth at high temperature and osmolarity..
Protein Sequence MSWKLTKKLKETHLASAIGLNSGGSSFTRGLKNSTLSSTSSRKSSDEKSRKSSEDKRSPQSTVVQPGLLQVTIIEARNLKLPSGHVPANYGVSIDNSLLAPPLSNGSGHARSRSHAWWLPYIVVEFDKNEILVDALNTASLENPCWDYQATFDVSRYSKLSLNIYLRSSSSRSRNGMGNDAFLGGIKLSPSFIVNKLTDEWVPLHGGSGELRVQMLYKPNQSTPLTIDAFELLKVVGKGSFGKVMQVRKRDTSRIYALKTMKKAHIVSRSEVDHTLAERTVLAQVNNPFIVPLKFSFQSPGKLYLVLAFVNGGELFHHLQREGCFDTYRAKFYIAELLVALECLHEFNVIYRDLKPENILLDYTGHIALCDFGLCKLNMAKTDRTNTFCGTPEYLAPELLLGHGYTKVVDWWTLGVLLYEMITGLPPFYDENINEMYRKILQDPLRFPDNIDEKAKDLLSGLLTRAPEKRLGSGGAQEIKNHPFFDDIDWKKLCAKKIQPPFKPSVESAIDTSNFDSEFTSEIPMDSVVADSHLSETVQQRFANWSYQRPTTIDTSDDINTIAPGSVIR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
16PhosphorylationLKETHLASAIGLNSG
HHHHHHHHHHCCCCC		27.1221712547
22PhosphorylationASAIGLNSGGSSFTR
HHHHCCCCCCCCHHH		49.9621712547
25PhosphorylationIGLNSGGSSFTRGLK
HCCCCCCCCHHHCCC		26.2921712547
26PhosphorylationGLNSGGSSFTRGLKN
CCCCCCCCHHHCCCC		33.6325720772
35PhosphorylationTRGLKNSTLSSTSSR
HHCCCCCCCCCCCCC		39.8021712547
37PhosphorylationGLKNSTLSSTSSRKS
CCCCCCCCCCCCCCC		31.4921712547
38PhosphorylationLKNSTLSSTSSRKSS
CCCCCCCCCCCCCCC		35.1121712547
40PhosphorylationNSTLSSTSSRKSSDE
CCCCCCCCCCCCCCH		30.0521712547
41PhosphorylationSTLSSTSSRKSSDEK
CCCCCCCCCCCCCHH		43.7621712547
44PhosphorylationSSTSSRKSSDEKSRK
CCCCCCCCCCHHHHC		41.7421712547
45PhosphorylationSTSSRKSSDEKSRKS
CCCCCCCCCHHHHCC		53.4724763107
49PhosphorylationRKSSDEKSRKSSEDK
CCCCCHHHHCCCCCC		42.7821712547
52PhosphorylationSDEKSRKSSEDKRSP
CCHHHHCCCCCCCCC		37.5421712547
53PhosphorylationDEKSRKSSEDKRSPQ
CHHHHCCCCCCCCCC		53.5021712547
62PhosphorylationDKRSPQSTVVQPGLL
CCCCCCCCCCCCCEE		21.3225720772
93PhosphorylationVPANYGVSIDNSLLA
CCCCCCCEECCCCCC		21.6229996109
97PhosphorylationYGVSIDNSLLAPPLS
CCCEECCCCCCCCCC		22.4729996109
382PhosphorylationCKLNMAKTDRTNTFC
EHHCCCCCCCCCCCC		22.6029996109
385PhosphorylationNMAKTDRTNTFCGTP
CCCCCCCCCCCCCCH		41.2329996109
387PhosphorylationAKTDRTNTFCGTPEY
CCCCCCCCCCCCHHH		21.4928889911
394PhosphorylationTFCGTPEYLAPELLL
CCCCCHHHHCHHHHH		14.9029996109
527PhosphorylationTSEIPMDSVVADSHL
CCCCCCCHHHCCCCC		16.5528889911
546PhosphorylationQQRFANWSYQRPTTI
HHHHHCCCCCCCCEE		15.9328889911
552PhosphorylationWSYQRPTTIDTSDDI
CCCCCCCEEECCCCC		21.3829996109
566PhosphorylationINTIAPGSVIR----
CCCCCCCCCCC----		17.2029996109
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
387TPhosphorylationKinaseKSG1Q12701
Uniprot
527SPhosphorylationKinaseTORC2-Uniprot
546SPhosphorylationKinaseTORC2-Uniprot
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GAD8_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GAD8_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SIN1_SCHPOsin1physical
21035342
G3P2_SCHPOgpd3physical
23213482
MUG72_SCHPOmug72physical
23213482
RS19B_SCHPOrps1902physical
23213482
RL17B_SCHPOrpl1702physical
23213482
IDH1_SCHPOidh1physical
23213482
RS6B_SCHPOrps602physical
23213482
P25_SCHPOobr1physical
23213482
AZET_SCHPOaca1physical
23213482
SVF1_SCHPOSPCC584.11cgenetic
22681890
PPR2_SCHPOppr2genetic
22681890
SNF5_SCHPOsnf5genetic
22681890
AP3D_SCHPOapl5genetic
22681890
MUG20_SCHPOmug20genetic
22681890
SPC2_SCHPOspc2genetic
22681890
POF15_SCHPOpof15genetic
22681890
SHF1_SCHPOshf1genetic
22681890
PIL2_SCHPOpil2genetic
22681890
PRZ1_SCHPOprz1genetic
22681890
TOP1_SCHPOtop1genetic
23703609
RAD22_SCHPOrad52genetic
23703609
TSC1_SCHPOtsc1genetic
24344203
TSC2_SCHPOtsc2genetic
24344203
FKH2_SCHPOfkh2physical
24344203
FKH2_SCHPOfkh2physical
24928510
SIN1_SCHPOsin1physical
28264193
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GAD8_SCHPO

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Schizosaccharomyces pombe AGC family kinase Gad8p forms a conservedsignaling module with TOR and PDK1-like kinases.";
Matsuo T., Kubo Y., Watanabe Y., Yamamoto M.;
EMBO J. 22:3073-3083(2003).
Cited for: FUNCTION, PHOSPHORYLATION AT THR-387; SER-527 AND SER-546, ANDMUTAGENESIS OF THR-387; SER-527 AND SER-546.

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