dbPTM

PIL2_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PIL2_SCHPO
UniProt AC	O14128
Protein Name	Probable sphingolipid long chain base-responsive protein pil2
Gene Name	pil2
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	383
Subcellular Localization
Protein Description	Negative regulator of cell wall integrity (CWI) in unstressed cells, probably by inhibiting protein kinase ksg1/ppk21 activity and regulating their downstream CWI pathways pck2-MAP kinase pathway and protein kinase gad8 pathway. Activity may be regulated by the transient increase of sphingolipid long chain bases (LCBs) during heat stress (By similarity)..
Protein Sequence	MGTQPSYSIHTLRAPPKAKQNQIPPSTTRRAVNVNKLGRQFRYPSVGMFTPEMAKRLAALVKMEKDLLRSYENVAMERKECANQLSYWGEDCDDDISDISDKLGVLLYEIGELEEHMVDRYDQYRVSLKTIRDIEASVQPTRVKKEKLLNSIYDVRSRDPESPKLITMEQELVREEAACLVAEAQLTNITRENFKRAFTLHIGTLLEHSEKVAILCGYAKKILDLLDDTPIVPGEPRPIYDGYNITRDYIVEAERELANWQNPFQTPEPLTDIDGLPSQSHYQTQFQASVVPRTDVINEPPRRYSHANGVTTSGTTHSYTSTGSKRYSQMGTEDYQPSFQPNILQSTQVVDNFEIGEEDDEEVGSQGVAETSMPSTSAQPIAA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
162	Phosphorylation	VRSRDPESPKLITME HHHCCCCCCCCEECC		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PIL2_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PIL2_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PIL2_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
YG58_SCHPO	SPBC56F2.08c	genetic	22681890
YLZ1_SCHPO	SPAC750.01	genetic	22681890
PYP1_SCHPO	pyp1	genetic	22681890
SPN5_SCHPO	spn5	genetic	22681890
CTBL1_SCHPO	SPAC1952.06c	genetic	22681890
TASP1_SCHPO	SPAC823.09c	genetic	22681890
YIFC_SCHPO	SPAC23G3.12c	genetic	22681890
YLO2_SCHPO	tma23	genetic	22681890
DAD1_SCHPO	dad1	genetic	22681890
FUS1_SCHPO	fus1	genetic	22681890
YMR1_SCHPO	ymr1	genetic	22681890
CWC16_SCHPO	saf4	genetic	22681890
YBPC_SCHPO	SPBC16H5.12c	genetic	22681890
DSC4_SCHPO	dsc4	genetic	22681890
RL43B_SCHPO	rpl4302	genetic	22681890
YDQ4_SCHPO	SPAC5D6.04	genetic	22681890
GPA2_SCHPO	gpa2	genetic	22681890
YOOH_SCHPO	SPBC887.17	genetic	22681890
YCO6_SCHPO	nap1	genetic	22681890
KPR1_SCHPO	SPAC4A8.14	genetic	22681890
MCL1_SCHPO	mcl1	genetic	22681890
RF1M_SCHPO	mrf1	genetic	22681890
MCM10_SCHPO	cdc23	physical	23695164
PIL2_SCHPO	pil2	physical	26771498
YF75_SCHPO	spa2	physical	26771498
PRP40_SCHPO	usp104	physical	26771498
MCM10_SCHPO	cdc23	physical	26771498
IMA2_SCHPO	imp1	physical	26771498
YHK5_SCHPO	SPBC660.05	physical	26771498
DHH1_SCHPO	ste13	physical	26771498
SOG2_SCHPO	sog2	physical	26771498
YGWC_SCHPO	SPBC8D2.12c	physical	26771498
YHP4_SCHPO	rmn1	physical	26771498
RNG3_SCHPO	rng3	physical	26771498

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PIL2_SCHPO

Related Literatures of Post-Translational Modification