SOG2_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SOG2_SCHPO
• UniProt AC: O94294
• Protein Name: Leucine-rich repeat-containing protein sog2
• Gene Name: sog2 {ECO:0000250|UniProtKB:Q08817}
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 886
• Subcellular Localization: Cytoplasm . Nucleus . Barrier septum. Cell tip.
• Protein Sequence: MSAHEVSSTKNSEIERIIKEAEDAGPENALTLDLSHLNLRELPYEQLERIQGRIARLALGHNFIKSIGPEILKFTRLRYLNIRSNVLREFPESLCRLESLEILDISRNKIKQLPESFGALMNLKVLSISKNRLFELPTYIAHMPNLEILKIENNHIVFPPPHIANNDLQDSDMQLFIANIKGYLSRNESVFRTRSESTVSAALSASANLSHSEENDSSVVDSYLFSAPSDTSHAVSPGMLTFVTPSPHSHSPAGHQQSTPKSTLSKTNENSEGTLYDSNVAHGCTHPPSLNQLNKFHLDASPRQARPRRSVSLATGLNSPSVSKPPSSATGPLYHSPQSSLTNSSVASADVQERTHNTNGASPIQDQISEFTDQHQNPSNNDAASTQSILKTAPTQLSASAKTSAISLPEVAKKERNRSNSTNDDYSSTRLPSSVLHRLEALKEARKLSEQLPNRIFAQDPHPSPRLKKEETHENGSNLTNDSVNSYFSNIGGSEVEMKHSAFEKTLESSRGILFSLSQVQQALRQQLLFCSNPVVLDSMRHVLHTANVQIKRLILCFEDTQQSNDGTANINSIVNASLSCISSFRKLIEVTKKFLNELTSRADVRYVRLLLLILFDAAKELQNALVPLSPSQPHSGNNIFADQVRQSPTSMIRTASGLTNRIVSVEKPASVMNPEIDKQIQDQVALATNSAMSVLTLLIDAVPKNNQPDLVNENIAPNLISKLRELGSLSAAACDVTRKLKHRLLTFQTNPEELEWQLFLDDTQAFVKSIIAVANLAKALSSEYTFQKSVLAGLSAATRSTKDLTILLSSSARHYTESSLATPVPLMSPIARVPATPLSAALGSAAQSITSPLIMSPAAIPASAYSTNKIDYFTDADGNVEGLQR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
301	Phosphorylation	NKFHLDASPRQARPR CCCCCCCCCCCCCCC	21.93	28889911
362	Phosphorylation	THNTNGASPIQDQIS HCCCCCCCCHHHHHH	24.76	29996109
392	Phosphorylation	STQSILKTAPTQLSA HHHHHHHHCCCCCCC	34.13	21712547
395	Phosphorylation	SILKTAPTQLSASAK HHHHHCCCCCCCCCC	39.41	25720772
398	Phosphorylation	KTAPTQLSASAKTSA HHCCCCCCCCCCCCC	15.45	24763107
400	Phosphorylation	APTQLSASAKTSAIS CCCCCCCCCCCCCCC	27.24	28889911
403	Phosphorylation	QLSASAKTSAISLPE CCCCCCCCCCCCHHH	24.09	25720772
404	Phosphorylation	LSASAKTSAISLPEV CCCCCCCCCCCHHHH	23.93	24763107
407	Phosphorylation	SAKTSAISLPEVAKK CCCCCCCCHHHHHHH	37.27	25720772
419	Phosphorylation	AKKERNRSNSTNDDY HHHHHCCCCCCCCCC	38.39	25720772
421	Phosphorylation	KERNRSNSTNDDYSS HHHCCCCCCCCCCHH	29.81	25720772
422	Phosphorylation	ERNRSNSTNDDYSST HHCCCCCCCCCCHHC	47.09	29996109
449	Phosphorylation	LKEARKLSEQLPNRI HHHHHHHHHHCCCCH	26.74	29996109
464	Phosphorylation	FAQDPHPSPRLKKEE HCCCCCCCCCCCHHH	21.44	28889911
648	Phosphorylation	FADQVRQSPTSMIRT CHHHHHCCCCHHHHH	21.41	28889911
657	Phosphorylation	TSMIRTASGLTNRIV CHHHHHCCCCCCCEE	33.45	27738172
823	Phosphorylation	YTESSLATPVPLMSP CCCCCCCCCCCCCCC	30.06	29996109
829	Phosphorylation	ATPVPLMSPIARVPA CCCCCCCCCCCCCCC	22.34	28889911
851	Phosphorylation	GSAAQSITSPLIMSP HHHHHHCCCCCCCCC	29.55	29996109
852	Phosphorylation	SAAQSITSPLIMSPA HHHHHCCCCCCCCCC	18.95	29996109
857	Phosphorylation	ITSPLIMSPAAIPAS CCCCCCCCCCCCCCH	12.37	29996109

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SOG2_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SOG2_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SOG2_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NAK1_SCHPO	nak1	genetic	24972934
CSK2A_SCHPO	cka1	physical	23462181
NAK1_SCHPO	nak1	physical	23462181
CSK2B_SCHPO	ckb1	physical	23462181
CSK2C_SCHPO	ckb2	physical	23462181

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-301 AND SER-464, ANDMASS SPECTROMETRY.
PubMed: 18257517