dbPTM

PRP40_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PRP40_SCHPO
UniProt AC	O14176
Protein Name	Pre-mRNA-processing protein prp40
Gene Name	prp40
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	695
Subcellular Localization	Nucleus.
Protein Description	Required for pre-spliceosome formation, which is the first step of pre-mRNA splicing. This protein is associated with snRNP U1 (By similarity)..
Protein Sequence	MSAPPWQTSEYDETEGFTSNQEGPSAAPSKTVASDWHEVKTEDSRVYYYNSVTRKSVWEKPEELMNDFEKKLSKLAWKEYATADGKKYWYNVNTRESVWDIPDEYKAALVDEPEQQKKALSSKIKSNDNKPAVQSIQRHGPDVAAPSSQPAKDQSQQISQGSHKRTINFVQQKDKRQKRSNDYQHENYDTYEAAERAFFKFLDSHNVNPSWTWEQTVRELCDAKGYYVMKDPWHRKCAFDAYILNYLTDQSDAEKNRVTKIRKEFIEMLKSSDKIHSYTLWRTVKNEFSSHPAFNATSSETEQQQLFFEYKQKLLEDEKQLEKDRRKEALDDFCSLLRNMNFEPYTRWSVAQAKFDQDPRYTRNSNMKYLSKLDALVAFEDHVKHLEREYILDKQKQKKEKHRIERKNRDAFRALLQDLRVQKKITLRTKWKELYPIIKDDPRYLNLLGQSGSTPLDLFWDTIVDLENMYREKRNLVLDCLEVLQISVDDTSNIPEIIARLSEKLKDREESEAVTEDLIEEVVNRLRDKAIHKKAEEKRADERRIRRKIDNLRSAIKYLKPPISADASYDEIRPLISILPEFAALHSEEHRMAAFDKYIRRLREKRELEKQYQNRRGYYDVGKDESYLANSARPHSGYEDGRLEYSADLASKSNRNEINTMQDVQENSISHVTATQPAVKNIVDDAESSEEGEIR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
688	Phosphorylation	NIVDDAESSEEGEIR HHHCCHHHCCCCCCC	44.78	28889911
689	Phosphorylation	IVDDAESSEEGEIR- HHCCHHHCCCCCCC-	31.04	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PRP40_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PRP40_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PRP40_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BST1_SCHPO	bst1	genetic	22681890
YLP3_SCHPO	red1	genetic	22681890
POF3_SCHPO	pof3	genetic	22681890
YQMA_SCHPO	SPCP1E11.10	genetic	22681890
PRP40_SCHPO	usp104	physical	26771498
MDV1_SCHPO	caf4	physical	26771498
TEA3_SCHPO	tea3	physical	26771498
MOC3_SCHPO	moc3	physical	26771498
ALP7_SCHPO	alp7	physical	26771498
YH7G_SCHPO	SPBC16G5.16	physical	26771498
CSK2C_SCHPO	ckb2	physical	26771498
PVG4_SCHPO	mbx2	physical	26771498
TAS3_SCHPO	tas3	physical	26771498
YHP6_SCHPO	mto2	physical	26771498
YHI5_SCHPO	abo2	physical	26771498

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PRP40_SCHPO

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of fission yeast."; Wilson-Grady J.T., Villen J., Gygi S.P.; J. Proteome Res. 7:1088-1097(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-688 AND SER-689, ANDMASS SPECTROMETRY.	18257517 [Abstract]