ALP7_SCHPO - dbPTM
ALP7_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ALP7_SCHPO
UniProt AC Q9URY2
Protein Name Microtubule protein alp7
Gene Name alp7
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 474
Subcellular Localization Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Associated with the equatorial MTOC, spindle midzones, spindle pole body and mitotic kinetochore periphery. Spindle and kinetochore localization is alp14-depen
Protein Description Required for bipolar spindle formation and proper chromosome segregation. Has an indirect role in connecting the kinetochores and the plus end of pole to chromosome microtubules by targeting alp14 to the spindle pole body. Involved in the emergence of large microtubule organizing centers (MTOC) in interphase cells. Attaches to the minus ends of microtubules and associates with the sites of microtubule attachment on the nuclear envelope. This leads to the stabilzation of the microtubule bundles..
Protein Sequence MSDIVSSSTDYSRRSPSSSSIGTNETDHTGFHEKRQGASSESLIPPAQRSSEESMPAPKLFPKLTSKPNPQLNLKDTLNKRVSDRLQALELNKSFDFSGTPRPMHPISHPLSQHKTPEFKHRKRNVESILTPKNPSLFSSSNAASQRGSLNTAPSNFAYSHSSSLQTSASSRPPVLSNGSFPRQTNTAPLNPPVHLKDNIRNSATPSTSQADIPTQYPINSTQKQQAKYEAEIEGYKAKLAGTYHEISVLQNTIVNVSGQLIAVNDQLQQLRSGKASTSPSTKDTNMRLVEGHNEETLALQRGKYTQEEVDKLIQERMEKVAEDLHAQYSAKHTQKINAFKANYARKYEATIQELQNQIGTAPNAPKISNSNWEEERRALKADNQTLQKQLEKAIQERQDMSDFLNNFKADMAKSDKLLMQQQSQQTGDLETLRLQLQALQEELRVEREERQQLIQMSEDLVIAMDQLNLEQKS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
9PhosphorylationSDIVSSSTDYSRRSP
CCCCCCCCCCCCCCC		40.6921712547
15PhosphorylationSTDYSRRSPSSSSIG
CCCCCCCCCCCCCCC		28.2025720772
17PhosphorylationDYSRRSPSSSSIGTN
CCCCCCCCCCCCCCC		44.0628889911
18PhosphorylationYSRRSPSSSSIGTNE
CCCCCCCCCCCCCCC		31.3325720772
19PhosphorylationSRRSPSSSSIGTNET
CCCCCCCCCCCCCCC		30.2529996109
20PhosphorylationRRSPSSSSIGTNETD
CCCCCCCCCCCCCCC		27.3029996109
39PhosphorylationHEKRQGASSESLIPP
CCCCCCCCCCCCCCH		41.2721712547
65PhosphorylationPKLFPKLTSKPNPQL
CCCCHHHCCCCCCCC		40.6121712547
66PhosphorylationKLFPKLTSKPNPQLN
CCCHHHCCCCCCCCC		57.4629996109
131PhosphorylationRNVESILTPKNPSLF
CCHHHCCCCCCHHHC		30.4624763107
278PhosphorylationLRSGKASTSPSTKDT
HHCCCCCCCCCCCCC		49.9029996109
279PhosphorylationRSGKASTSPSTKDTN
HCCCCCCCCCCCCCC		17.8529996109
369PhosphorylationAPNAPKISNSNWEEE
CCCCCCCCCCCHHHH		40.0929996109
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ALP7_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ALP7_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ALP7_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MAD2_SCHPOmad2genetic
12951601
ALP14_SCHPOalp14physical
14742702
XPO1_SCHPOcrm1physical
19606211
ALP14_SCHPOalp14physical
19606211
NDC80_SCHPOndc80physical
23427262
ALP14_SCHPOalp14physical
23427262
ALP14_SCHPOalp14physical
23695164
ALP14_SCHPOalp14physical
23770679
DIS1_SCHPOdis1genetic
24937146
MAD2_SCHPOmad2genetic
24937146
PCP1_SCHPOpcp1physical
24937146
ALP14_SCHPOalp14physical
24790093
IMA1_SCHPOcut15physical
24790093
ALP7_SCHPOalp7physical
26771498
RAD26_SCHPOrad26physical
26771498
MCM10_SCHPOcdc23physical
26771498
IMA2_SCHPOimp1physical
26771498
LCF2_SCHPOlcf2physical
26771498
SPF30_SCHPOspf30physical
26771498
ALP14_SCHPOalp14physical
26771498
ALP7_SCHPOalp7physical
26864000
MAD2_SCHPOmad2genetic
25472718
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ALP7_SCHPO

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-17, AND MASSSPECTROMETRY.

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