| UniProt ID | NDC80_SCHPO | |
|---|---|---|
| UniProt AC | Q10198 | |
| Protein Name | Kinetochore protein ndc80 | |
| Gene Name | ndc80 | |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). | |
| Sequence Length | 624 | |
| Subcellular Localization | Nucleus. Chromosome, centromere, kinetochore. Associated with kinetochores. | |
| Protein Description | Acts as a component of the NMS (Ndc80-MIND-Spc7) super complex which has a role in kinetochore function during late meiotic prophase and throughout the mitotic cell cycle. Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.. | |
| Protein Sequence | MQDSSSYARRYSQAPSSSNLRTTTFGFNGLGTSRTSLAPQRTLVNARQSIDPDGLSSRVLTPTMRPSLAPNTRRSSVRVSNASFISQTPNITSIKDPRPLSDRRYQQECATQVVNYLLESGFSQPLGLNNRFMPSTREFAAIFKHLYNKLDPNFRFGARYEEDVTTCLKALNYPFLDSISRSRLVAIGSPHVWPAILGMLHWVVSLIQCTEKAVAMVYTVEQNSLDDHLVDKVLFDYLVRTYHLYLDESPEESEPEKELKATFNQQNQDLYNQTEALKSTNEELINQIKSAEELDSAIQVLEERYRTMQRDEVKFQSAMSGMKSKMESRTNLMKQLQVNIEEKESQLQLLKEKRDSLKYQVENQDISISEFEKMVSEREQLDRNLNMIGSKISELRKEVFDTDLLIQASIDSLEKKVQKFNSLAYRIGIVPIAAIRSANNDFELEINPEGPNYINLDLKNKVRPFINEVRRSITLEFHEEQNKSLKLQEHVDTVNDLIAELQDELRGIESRLTSVLSECNMLRETASEEKNAFDAESDKLERELQQLKLSSHNSMLQLDQRIQSINIEADQIAHACMEYKNNIYKEVAFVLGEIIHFKLHVQDSLEDLKMDYQKELDDLSRSEL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 12 | Phosphorylation | SSYARRYSQAPSSSN HHHHHHHCCCCCCCC | 20.32 | 29996109 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NDC80_SCHPO !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NDC80_SCHPO !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NDC80_SCHPO !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| NUF2_SCHPO | nuf2 | physical | 15728720 | |
| SPC24_SCHPO | spc24 | physical | 15728720 | |
| SPC25_SCHPO | spc25 | physical | 15728720 | |
| DIS1_SCHPO | dis1 | physical | 21256022 | |
| DIS1_SCHPO | dis1 | genetic | 21256022 | |
| MAD2_SCHPO | mad2 | genetic | 23427262 | |
| ALP7_SCHPO | alp7 | physical | 23427262 | |
| ALP7_SCHPO | alp7 | genetic | 23427262 | |
| DIS1_SCHPO | dis1 | genetic | 23427262 | |
| PP11_SCHPO | dis2 | genetic | 25472718 | |
| BUB3_SCHPO | bub3 | genetic | 25472718 | |
| KLP5_SCHPO | klp5 | genetic | 25472718 | |
| KLP6_SCHPO | klp6 | genetic | 25472718 | |
| ALP7_SCHPO | alp7 | genetic | 25472718 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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