| UniProt ID | KLP5_SCHPO | |
|---|---|---|
| UniProt AC | O14343 | |
| Protein Name | Kinesin-like protein 5 | |
| Gene Name | klp5 | |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). | |
| Sequence Length | 883 | |
| Subcellular Localization | Cytoplasm . Cytoplasm, cytoskeleton . Chromosome, centromere, kinetochore . Cytoplasm, cytoskeleton, spindle . Cytoplasmic microtubules in interphase, mitotic kinetochores in metaphase and spindle midzone in anaphase and telophase. | |
| Protein Description | Has a role in establishing metaphase during mitosis. Required for chromosome segregation where it generates tension during kinetochore capturing.. | |
| Protein Sequence | MSRQSSITVTVRVRPFSTAESANLIASSDRLSFGTSSSLRNPGSGRQIRRVVKVLDGRVLVFDPPDETTATLSATNRRLSTSQQSLARLSRKSNNSAGFGRDLRYAFDRVFDETATQQQVYERTARPLLDNILDGFNATIFAYGATGCGKTHTISGTMQDPGLIYLTLKELFERMDHLRDEKIFDLRLSYLEIYNETIRDLLVSPTPNQAKPLNLREDADRRITVPGLTSLSPESLEEIIDIIMKGNANRTMSPTEANAASSRSHAVLQVTLIQKPRTAGINEDHTLATLSIIDLAGSERATATKLRGSRLFEGANINKSLLALGNCINALCDPHRRAHVPYRDSKLTRLLKFSLGGNCRTVMIVCVSPSSVHYEETHNTLKYANRAKNIKTEVLRNMISVDRHVSQYVKAIVELREQISELENRLAQIDLSSQSNGSDQDAVTQSFAHESKLAEARNLLRMTFEETLPLQNDTINKVEKVKHFDDSIRVLKYWLSCYERILPNSADERVFLVRSKLESLLTRRAEIIADIDPELVYQKFQRSVSHIINTYKQEGATMYADVLQDEVDLLKSIIENQVLDAQNKVDEFTPVLESLLRSSFKASSLLKEGGMQELFSILEKWLLGIGLGEKPNISVLSESYKLNSTSDDSRTINRDRVHSFPTQPLLNNNLPRMFFVKSPKKPVVFSKRSPKKRVRFDDSMSTSDSGASAYNSPIQTSKLKNMNFFNTMHMPSTPAHKRPENKNQIDVEINLTSPVSPMLEDKPEPGLLIKSPLEKKQEVNSESTQLDQLLAEDSSTDDVSLPHLDTIDLDGSPVPKVPDLNFSRANMDSPTFILNNEAIHNFDFSKPKTRQSLSSLTTLHLSNPANIIRKSLSMAENEEEKAT | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 80 | Phosphorylation | SATNRRLSTSQQSLA HHHHCCCCHHHHHHH | 24.97 | 25720772 | |
| 81 | Phosphorylation | ATNRRLSTSQQSLAR HHHCCCCHHHHHHHH | 34.84 | 29996109 | |
| 85 | Phosphorylation | RLSTSQQSLARLSRK CCCHHHHHHHHHHHH | 19.16 | 25720772 | |
| 678 | Phosphorylation | PRMFFVKSPKKPVVF CCEEEECCCCCCEEE | 36.33 | 21712547 | |
| 703 | Phosphorylation | FDDSMSTSDSGASAY CCCCCCCCCCCCHHC | 23.60 | 21712547 | |
| 705 | Phosphorylation | DSMSTSDSGASAYNS CCCCCCCCCCHHCCC | 35.71 | 21712547 | |
| 710 | Phosphorylation | SDSGASAYNSPIQTS CCCCCHHCCCCCCCC | 17.43 | 21712547 | |
| 712 | Phosphorylation | SGASAYNSPIQTSKL CCCHHCCCCCCCCCC | 15.65 | 21712547 | |
| 752 | Phosphorylation | IDVEINLTSPVSPML CCEEEEECCCCCHHC | 26.88 | 21712547 | |
| 753 | Phosphorylation | DVEINLTSPVSPMLE CEEEEECCCCCHHCC | 26.86 | 21712547 | |
| 756 | Phosphorylation | INLTSPVSPMLEDKP EEECCCCCHHCCCCC | 14.15 | 21712547 | |
| 771 | Phosphorylation | EPGLLIKSPLEKKQE CCCCEECCCCHHCHH | 27.94 | 21712547 | |
| 829 | Phosphorylation | FSRANMDSPTFILNN CCCCCCCCCEEEECC | 18.31 | 29996109 | |
| 831 | Phosphorylation | RANMDSPTFILNNEA CCCCCCCEEEECCHH | 27.53 | 29996109 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of KLP5_SCHPO !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of KLP5_SCHPO !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of KLP5_SCHPO !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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