SPC7_SCHPO - dbPTM
SPC7_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SPC7_SCHPO
UniProt AC O59757
Protein Name Kinetochore protein spc7
Gene Name spc7
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 1364
Subcellular Localization Nucleus . Chromosome, centromere, kinetochore . Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body .
Protein Description Acts as a component of the NMS (Ndc80-MIND-Spc7) super complex which has a role in kinetochore function during late meiotic prophase and throughout the mitotic cell cycle..
Protein Sequence MPTSPRRNSIATTDNVIGRNKSRKRPHSLGGPGALQELKEHTNPAKGILKSYSSFSVDPAFTGDEDFNDIHTQINNTVIGISSNVMAASKRLQMEDLQQLSRETSRKSLNRRVSFASHARVRWYPKDHQSDSEKSTSNHSTPERTFASDAKNHSPKGPTTTSFSRNETQSSPHSHSASIISDGSDMDIASPIRSTESDMVSEALNAGHPPPSLYPENDDLSIQNPTKALPEAEKALDVHDATREQVNDREETNMDLTIQFQEADSFLSHSESIKGLSSSEQGTVYSLKASHDPSNQTQLSSPNKSSSPTSIEISDFSKNNENHDQSENKEEEEDMMLTRPIEIPQHFSPIARPLTSQEAIVDMDITSNNINLSPVSHFSNGLDLQNLEEAPMNLTRPINANPHLTNHSPNDLTNGEEEMDTTSAFNIENSHLTLLSPIRPSSRSMEEQIMDLTQPISSTNAPTHLNEDDLNQFTSNISSSSKPRKDNNKTANSSKPIPDSEDFMDITRPFNILSPSKEALSEEQPMELTSTVFPCENSTSHLEVEEAAMDETVAFQIRGNNVELPSADKENAEREEIPSYSDKSENFNTTSFTNHERSPNGNNNLKFSKDPNSSSPSRHVVATPTDKLGTRKRRLRYSTSSFDQSTLRRNRLATIRNARKSISTLNDRELLPVNFFEKKVNSGLYKSVERSENYRLGATPLTAEKPFTTEKPLSSLPEEVSRQPTDDKGEQVSNADVDSGLSKTERLTIQQTNEIKHVPTNTTSSVKLPQQPSNEDEKERITTADYADSTSLERLESQEPNRNELVQVGSSNAGNTTSVGMNEHEKSPVKLSKGVSNVDTSLGASTINTNILNQDSGPNEEIPVGNEPEFDTMPTLPNVEPISLSDFLKMTGIEFLDNLTIAKRRETLLPNAEENKKCSIQELLESFYIQFPLLELYKFSCQQLQDYIAEGKDFVTKIEEETLKENPLLFYEYRKASSDMRVLMDSQFLMMKTFARLQAKGDWYEWREGLMQGIKHELNLNLTGMQRSLTHLMDVANVIHPYAQEIQERYNGSITTVQTLKKQKEFANQYDSTLLAQAQEKLEKLKVEVERRRRLLSEKEERRKELAIKIEQVTNSCSDLELRTNAEQDFYAKNQDFEFDEIKRYEEQLLNLKNELGWTIVSLTAGGIKLATNNTALSPYSAEVTVEILRQNFQVNVDIACKFPNESNACSSNVLEHVASSFSKWHSKVFSRNLRLLKKYLNDVSICWEQIVYLVQDFQRLWYHWPFLSVENDDKSIIINVELYLRSVSSKVKVVFGLPIDTIYQTTEVGKFYASTSVAVKQMYAESEGDSYVSEVLNTLSEVVHCTSTYALSSACLTVWNKYS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----MPTSPRRNSI
-----CCCCCCCCCC		64.3221712547
4Phosphorylation----MPTSPRRNSIA
----CCCCCCCCCCC		27.4321712547
9PhosphorylationPTSPRRNSIATTDNV
CCCCCCCCCCCCCCC		16.2821712547
28PhosphorylationKSRKRPHSLGGPGAL
CCCCCCCCCCCCCHH		31.2421712547
154PhosphorylationASDAKNHSPKGPTTT
CCCCCCCCCCCCCCC		37.3925720772
290PhosphorylationTVYSLKASHDPSNQT
CEEEEEECCCCCCCC		27.1725720772
297PhosphorylationSHDPSNQTQLSSPNK
CCCCCCCCCCCCCCC		35.4125720772
300PhosphorylationPSNQTQLSSPNKSSS
CCCCCCCCCCCCCCC		33.6521712547
301PhosphorylationSNQTQLSSPNKSSSP
CCCCCCCCCCCCCCC		40.8724763107
305PhosphorylationQLSSPNKSSSPTSIE
CCCCCCCCCCCCEEE		42.5625720772
306PhosphorylationLSSPNKSSSPTSIEI
CCCCCCCCCCCEEEE		41.7829996109
307PhosphorylationSSPNKSSSPTSIEIS
CCCCCCCCCCEEEEE		39.0128889911
589PhosphorylationDKSENFNTTSFTNHE
CCCCCCCCCCCCCCC		21.4921712547
598PhosphorylationSFTNHERSPNGNNNL
CCCCCCCCCCCCCCC		21.5224763107
613PhosphorylationKFSKDPNSSSPSRHV
CCCCCCCCCCCCCCE		37.2724763107
614PhosphorylationFSKDPNSSSPSRHVV
CCCCCCCCCCCCCEE		53.5629996109
615PhosphorylationSKDPNSSSPSRHVVA
CCCCCCCCCCCCEEE		27.0729996109
617PhosphorylationDPNSSSPSRHVVATP
CCCCCCCCCCEEECC		36.6521712547
661PhosphorylationTIRNARKSISTLNDR
HHHHHHHHHHCCCCC		19.0721712547
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SPC7_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SPC7_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SPC7_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MIS12_SCHPOmis12physical
15502821
MAL3_SCHPOmal3physical
15371542
NUF2_SCHPOnuf2physical
16079914
MIS12_SCHPOmis12physical
16079914
SPC24_SCHPOspc24physical
16079914
MIS13_SCHPOmis13physical
16079914
MIS14_SCHPOmis14physical
16079914
SPC25_SCHPOspc25physical
16079914
NDC80_SCHPOndc80physical
16079914
MPH1L_SCHPOmph1genetic
17442892
MAD2_SCHPOmad2genetic
17442892
MIS6_SCHPOmis6genetic
17442892
SIM4_SCHPOsim4genetic
17442892
MIS17_SCHPOmis17genetic
17442892
MAL2_SCHPOmal2genetic
17442892
TBA2_SCHPOatb2physical
17442892
STU1_SCHPOpeg1genetic
17442892
ALP14_SCHPOalp14genetic
17442892
NUF2_SCHPOnuf2genetic
21712547
BUB1_SCHPObub1physical
22660415
BUB3_SCHPObub3physical
22660415
SOS7_SCHPOsos7genetic
22711988
SOS7_SCHPOsos7physical
22711988
BAG1B_SCHPObag102genetic
24497846
HSP7M_SCHPOssc1physical
24497846
PRS4_SCHPOrpt2genetic
24497846
YD58_SCHPOnas6genetic
24497846
UBC4_SCHPOubc4genetic
24497846
UBR11_SCHPOubr11genetic
24497846
YGI4_SCHPOsan1genetic
24497846
YFK7_SCHPOhul5genetic
24497846
UBR1_SCHPOubr1genetic
24497846
UBP3_SCHPOubp3genetic
24497846
PP11_SCHPOdis2physical
21664573
MAD2_SCHPOmad2genetic
21664573
MAD3_SCHPOmad3genetic
21664573
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SPC7_SCHPO

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Related Literatures of Post-Translational Modification

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