| UniProt ID | MAD3_SCHPO | |
|---|---|---|
| UniProt AC | O59767 | |
| Protein Name | Mitotic spindle checkpoint component mad3 | |
| Gene Name | mad3 | |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). | |
| Sequence Length | 310 | |
| Subcellular Localization | Nucleus . Chromosome, centromere, kinetochore . Associated with the kinetochore. | |
| Protein Description | Has a role in transducing the anaphase inhibitory signal to the anaphase promoting complex (APC). Forms part of the mad2 feedback control.. | |
| Protein Sequence | MEPLDAGKNWVHMDVIEQSKENIEPRKAGHSASALAKSSSRNHTEKEVAGLQKERMGHERKIETSESLDDPLQVWIDYIKWTLDNFPQGETKTSGLVTLLERCTREFVRNPLYKDDVRYLRIWMQYVNYIDEPVELFSFLAHHHIGQESSIFYEEYANYFESRGLFQKADEVYQKGKRMKAKPFLRFQQKYQQFTHRWLEFAPQSFSSNTNSVNPLQTTFESTNIQEISQSRTKISKPKFKFSVYSDADGSGKDGQPGTWQTLGTVDQRRKENNISATSWVGEKLPLKSPRKLDPLGKFQVHCDEEVSKE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 289 | Phosphorylation | GEKLPLKSPRKLDPL CCCCCCCCCCCCCCC | 37.31 | 21712547 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MAD3_SCHPO !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MAD3_SCHPO !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MAD3_SCHPO !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| BUB1_SCHPO | bub1 | physical | 11909965 | |
| BUB3_SCHPO | bub3 | physical | 11909965 | |
| BUB1_SCHPO | bub1 | physical | 15525673 | |
| SLP1_SCHPO | slp1 | physical | 11909965 | |
| MAD2_SCHPO | mad2 | physical | 11909965 | |
| MAD2_SCHPO | mad2 | physical | 12676091 | |
| TBG_SCHPO | gtb1 | genetic | 17277378 | |
| APC4_SCHPO | cut20 | physical | 18556659 | |
| APC1_SCHPO | cut4 | physical | 18556659 | |
| APC2_SCHPO | apc2 | physical | 18556659 | |
| APC3_SCHPO | nuc2 | physical | 18556659 | |
| APC5_SCHPO | apc5 | physical | 18556659 | |
| CUT9_SCHPO | cut9 | physical | 18556659 | |
| APC8_SCHPO | cut23 | physical | 18556659 | |
| APC10_SCHPO | apc10 | physical | 18556659 | |
| APC11_SCHPO | apc11 | physical | 18556659 | |
| HCN1_SCHPO | hcn1 | physical | 18556659 | |
| APC13_SCHPO | apc13 | physical | 18556659 | |
| APC14_SCHPO | apc14 | physical | 18556659 | |
| APC15_SCHPO | apc15 | physical | 18556659 | |
| SLP1_SCHPO | slp1 | physical | 18556659 | |
| MAD2_SCHPO | mad2 | physical | 18556659 | |
| MAD1_SCHPO | mad1 | physical | 22825872 | |
| MAD2_SCHPO | mad2 | physical | 22825872 | |
| BUB3_SCHPO | bub3 | physical | 28366743 | |
| SLP1_SCHPO | slp1 | genetic | 28366743 | |
| SLP1_SCHPO | slp1 | physical | 28366743 | |
| MAD2_SCHPO | mad2 | physical | 28366743 | |
| APC4_SCHPO | cut20 | physical | 28366743 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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